Chiral separation and quantification of R/S-amphetamine, R/S-methamphetamine, R/S-MDA, R/S-MDMA, and R/S-MDEA in whole blood by GC-EI-MS

Stereoselective method development and validation for determination of concentrations of amphetamine-type stimulants and metabolites in human urine using a simultaneous extraction–chiral derivatization approach

“…Among CDRs commonly used are S-(−)-N-(heptafluorobutyryl)prolyl chloride (S-HFBPCl) [9][10][11], S-(−)-N-(trifluoroacetyl)prolyl chloride (S-TPC) [12][13][14][15] and R-(−)-␣-methoxy-␣-(trifluoromethyl)phenylacetyl chloride (R-MTPCl) [3,[16][17][18][19]. Derivatization with S-HFBPCl results in diastereomers with excellent chromatographic properties and distinctive mass spectra, however the use of S-HFBPCl is disadvantageous as it is not commercially available and needs to be synthesized in the laboratory [20].…”

Fast and Sensitive Chiral Analysis of Amphetamines and Cathinones in Equine Urine and Plasma Using Liquid Chromatography Tandem Mass Spectrometry

“…In animal studies, the CNS stimulant activities increase in the order of (S)-amphetamine, (S)-cathinone, (S)-metham-phetamine and (S)-methcathinone [1]. Research results showed that the S-enantiomers of the four compounds demonstrated more CNS stimulant potency than the corresponding R-enantiomers due to the binding affinity differences to their receptor sites [9]- [13]. In the United States, (R)-methamphetamine is available in some over-thecounter nasal decongestant products, such as Vicks-Vapor inhaler and its generic equivalents.…”

“…The illicitly manufactured methamphetamine consists mainly the S-enantiomer. Unambiguous identification of enantiomers can be extremely useful in clinical, forensic, and toxicological applications to distinguish illicit consumption, origin and the metabolism of the target compound [8]- [13].…”

Development of Advanced Capillary Electrophoresis Techniques with UV and Mass Spectrometry Detection for Forensic, Pharmaceutical and Environmental Applications

“…As with many chiral active pharmaceutical ingredients, the pharmacological effect of the enantiomers of those psychoactive compounds can differ [99][100][101]. The enantiomeric separation of cathinone analogs may become important as these isomers can perform different functions in drug design and other aspects.…”

“…Many different types of instrumentation and methods have been utilized for the separation of cathinone analogs, including HPLC [102][103][104], GC [99,105,106], and CE [107][108][109][110]. Compared to HPLC and GC, CE demonstrates numerous advantages including high efficiency and resolution, and the capability to perform chiral separations through the addition of chiral selectors to the background electrolyte (BGE).…”