Chiral separation by nonaqueous capillary electrophoresis using <scp>l</scp>-sorbose–boric acid complexes as chiral ion-pair selectors

Lv, Lili; Wang, Limin; Zou, Yunling; Chen, Rui; Yu, Jiaojiao

doi:10.1039/c6ra21806g

Cited by 7 publications

(3 citation statements)

References 36 publications

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“…Also, Lv et al. evaluated the potential of L‐sorbose‐boric acid complexes as the chiral ion‐pair selectors for the enantioseparation of nineteen basic drugs including two fluoroquinolones (lomefloxacin and gatifloxacin) by NACE‐UV . The effects of boric acid, L‐sorbose, and triethylamine concentrations, separation voltage and temperature were investigated and the optimal conditions for the enantioseparation of both antibiotics consisted of the use of 100 mM boric acid, 60 mM L‐sorbose, and 14.4 mM trimethylamine in MeOH.…”

Section: Ce and Cec With Uv Detectionmentioning

confidence: 99%

Analysis of antibiotics by CE and CEC and their use as chiral selectors: An update

et al. 2017

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Natural, synthetic or semisynthetic antibiotics are highly used to prevent or treat diseases in humans and animals, and to promote animal growth. This fact makes that antibiotics residues or their transformation products may be present in food or in the environment after human or animal excretion. For this reason, it is imperative to develop reliable and sensitive analytical methodologies for their analysis. The main aim of this work is to present and discuss the most recent applications of capillary electromigration methods for the analysis of antibiotics, including the developments and applications of their use as chiral selectors in CE. The literature published from June 2015 to June 2017 is included following the previous review by Domínguez‐Vega et al. (Electrophoresis, 2016, 37, 189–211). Information about the use of different detection systems, off‐line and on‐line strategies to improve sensitivity, and microchip devices for the analysis of antibiotics is provided and properly discussed.

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Section: Ce and Cec With Uv Detectionmentioning

confidence: 99%

Analysis of antibiotics by CE and CEC and their use as chiral selectors: An update

et al. 2017

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“…Several methods have been reported for the determination of ESM including spectroscopic methods , chromatographic methods , gas chromatography‐mass spectrometry and liquid chromatography‐mass spectrometry , capillary electrophoresis and capillary zone electrophoresis methods. These techniques need sample pretreatment and expensive instrumentation.…”

Section: Introductionmentioning

confidence: 99%

Development of a Surfactant/Platinum Composite for Sensitive Cardio‐selective Beta Blocker Detection and their Theoretical Studies

et al. 2019

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An electrooxidative behavior of beta‐blocker drug esmolol was thoroughly investigated by using glassy carbon electrode modified with sodium dodecyl sulfate‐based platinum nanoparticles. The designed nanosensor exhibited remarkable electro‐catalytic effect by dramatically boosting the signal of the esmolol as compared to the bare electrode with detection limit up to picomolar. The effects of pH, scan rate, temperature, deposition potential, deposition time, effect of electrolyte and interfering agents were investigated to optimize conditions for getting intense signal of the analyte. Under optimized experimental conditions, a linear calibration plot for esmolol with a detection limit of 60 pM was obtained. The analyte sensing ability of the modified electrode was supported by the application of theoretical studies that showed favorable interaction between sodium dodecyl sulfate/platinum nanoparticles composite and esmolol. In this study, our aim was to developed a nanosensor for the sensitive detection of esmolol by electrochemical assay. We tried a lot of different modification style and modifiers for creating a sensitive nanosensor for esmolol. This nanosensor can be applied to the esmolol in serum sample without using any further separation, evaporation or precipitation steps. Application could apply in serum sample to test accuracy of our sensor and method. The high recovery results were observed in serum study.

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“…The enantioseparation of chiral compounds is very important in pharmaceutical industry . CE has proved to be one of the most effective methods for enantiomers' separation due to its high efficiency, robustness, low cost, simplicity, and diversity regarding different modes, such as ACE , MEKC , and NACE . The enantioseparation can be achieved using different types of chiral selectors, such as cyclodextrin and its derivatives , cyclofructans , crown ether , DNA , macrocyclic antibiotics , ionic liquids , chiral metal‐ion complexes , and proteins .…”

Section: Introductionmentioning

confidence: 99%

Predefine resolution of enantiomers in partial filling capillary electrophoresis and two discontinuous function plugs coupling in‐capillary

et al. 2018

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In common partial filling CE (PF-CE), the capillary contains the selectors plug between the injection and detector end to avoid the selector going into the detector zone. To expand this method, we propose a mode of two discontinuous function plugs coupling in-capillary, named as plug-plug PF-CE (ppPF-CE). Initially, we present the method to predefine the effective length of chiral selector to meet the requirement of enantiomers' resolution, which could avoid some experimental procedures. With α-CD as a chiral selector, a satisfactory resolution of enantiomers d,l-tryptophan and d,l-tyrosine was obtained with a partial filling α-CD plug of optimal length and concentration. Subsequently, a second plug containing hydroxypropyl methylcellulose, organic solvents (acetonitrile and methanol), anionic and cationic surfactants (SDS and CTAB), and different concentrations of sodium phosphate buffer was inserted after the selector plug. Effects of plug-plug filling on enantiomers' migration and resolution are discussed. The ppPF-CE might be a new flexible mode for CE application.

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Chiral separation by nonaqueous capillary electrophoresis using l-sorbose–boric acid complexes as chiral ion-pair selectors

Abstract: A chiral nonaqueous capillary electrophoresis (NACE) method using l-sorbose–boric acid complexes as the chiral ion-pair selectors was developed for enantioseparation of nineteen chiral analytes.

Cited by 7 publications

References 36 publications

Analysis of antibiotics by CE and CEC and their use as chiral selectors: An update

Analysis of antibiotics by CE and CEC and their use as chiral selectors: An update

Development of a Surfactant/Platinum Composite for Sensitive Cardio‐selective Beta Blocker Detection and their Theoretical Studies

Predefine resolution of enantiomers in partial filling capillary electrophoresis and two discontinuous function plugs coupling in‐capillary

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