Chiral separation in capillary electrophoresis

Abstract

A mathematical model which explains separation in chiral capillary electrophoresis is presented. The model is analysed to give a more general solution than previous work and is supported by further experimental work.

Review of aqueous chiral electrokinetic chromatography (EKC) with an emphasis on chiral microemulsion EKC

“…Mathematical models for optimizing chiral selector conditions with CDs have been developed by Wren and Rowe [30][31][32][33]. Kafri and Lancet [34] examined chromatographic data and proposed the string model for enantiorecognition (SMED).…”

Direct enantiomeric resolution of (±)‐atenolol, (±)‐metoprolol, and (±)‐propranolol by impregnated TLC using L‐aspartic acid as chiral selector

“…(AE)-Atenolol has been resolved using capillary electrophoresis (Wren, 1995), HPLC (Miller and Guertin, 1992;He et al, 1993), and HPTLC (Tivert and Beckman, 1993). (AE)-Metoprolol has been resolved using HPLC (Bueschges et al, 1996), and (AE)-propranolol has been resolved by different chromatographic methods (Facklam and Modeler, 1994;Aboul-Enein et al, 1996).…”

Chiral separations by capillary electrophoresis: Recent developments and applications

“…Wren and Rowe [10][11][12] have developed a theoretical model relating mobility to the concentration of a CD selector. The following complexation equilibria exist for a pair of enantiomers (E 1 E 2 ) and a chiral selector (S), assuming a 1:1 interaction between the enantiomer and the chiral selector, which is mostly the case [4,7,10]:…”