Chiral separation of new chiral insecticide pyraquinil isomers and establishment of analytical methods in vegetables

Chen, Yan; Huang, Congling; Jiang, Xunyuan; Chen, Zhiting; Wang, Gang; Wan, Kai; Tang, Xuemei

doi:10.3724/sp.j.1123.2022.01011

Cited by 1 publication

(2 citation statements)

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“…38 To date, the only existing research related to environmental behavior has been the establishment of the stereoselective analytical methods of pyraquinil isomers in vegetables. 39 Research on the degradation kinetics, potential TPs, and degradation pathways of pyraquinil in water has not yet been reported. Moreover, the toxicity of pyraquinil and its TPs to aquatic organisms remains unknown.…”

Section: Introductionmentioning

confidence: 99%

“…In consideration of the long persistence, negative impact on the ecosystem, and toxic TPs of the traditional GABA receptor antagonist insecticides (such as fipronil), it was essential to carry out research on the environmental behavior and ecological toxicity of pyraquinil as well as its TPs. − However, as a new pesticide, previous studies on pyraquinil were mainly focused on its synthesis method, − insecticidal activity, , mode of action, , and toxicokinetics . To date, the only existing research related to environmental behavior has been the establishment of the stereoselective analytical methods of pyraquinil isomers in vegetables . Research on the degradation kinetics, potential TPs, and degradation pathways of pyraquinil in water has not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

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Degradation of the Novel Heterocyclic Insecticide Pyraquinil in Water: Kinetics, Degradation Pathways, Transformation Products Identification, and Toxicity Assessment

Jiang

Xiao

Chen

et al. 2023

J. Agric. Food Chem.

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As new pesticides are continuously introduced into agricultural systems, it is essential to investigate their environmental behavior and toxicity effects to better evaluate their potential risks. In this study, the degradation kinetics, pathways, and aquatic toxicity of the new fused heterocyclic insecticide pyraquinil in water under different conditions were investigated for the first time. Pyraquinil was classified as an easily degradable pesticide in natural water, and hydrolyzes faster in alkaline conditions and at higher temperatures. The formation trends of the main transformation products (TPs) of pyraquinil were also quantified. Fifteen TPs were identified in water using ultrahigh-performance liquid chromatography coupled to quadrupole Orbitrap high-resolution mass spectrometry (UHPLC-Orbitrap-HRMS) and Compound Discoverer software, which adopted suspect and nontarget screening strategies. Among them, twelve TPs were reported for the first time and 11 TPs were confirmed by synthesis of their standards. The proposed degradation pathways have demonstrated that the 4,5-dihydropyrazolo[1,5-a]quinazoline skeleton of pyraquinil is stable enough to retain in its TPs. ECOSAR prediction and laboratory tests showed that pyraquinil was “very toxic” or “toxic” to aquatic organisms, while the toxicities of all of the TPs are substantially lower than that of pyraquinil except for TP484, which was predicted to pose a higher toxicity. The results are important for elucidating the fate and assessing the environmental risks of pyraquinil, and provide guidance for scientific and reasonable use.

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Section: Introductionmentioning

confidence: 99%