Chiral Separations

Ward, Timothy J.

doi:10.1021/ac060622o

Cited by 85 publications

(55 citation statements)

References 218 publications

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“…[6][7][8][9][10] In CE, the enantioselectivity is based on the chiral selector, which is dissolved in the running buffer. During the last decade, various types of chiral selectors, such as cyclodextrins (CDs) and their derivatives, 11,12 crown ethers, 13 chiral surfactants, 14,15 polysaccharides, 16,17 macrocyclic antibiotics, 18 proteins, 19 and metal complexes 20,21 have been widely used in CE.…”

Section: Introductionmentioning

confidence: 99%

Enantioseparation of Palonosetron Hydrochloride by Capillary Zone Electrophoresis with High-concentration β-CD as Chiral Selector

et al. 2009

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The enantioseparation of four stereoisomers of palonosetron hydrochloride (PALO) by capillary zone electrophoresis using high concentration β-CD as chiral selector was described in this study. For optimization of the method of enantioseparation, several parameters such as β-CD concentration, separation buffer pH and concentration, the types and concentration of organic modifiers, and the applied voltage were evaluated. The optimum conditions were obtained as follows: 30 mmol L -1 NaH2PO4 (pH 3.0) containing 150 mmol L -1 β-CD and 10% (v/v) methanol with an applied voltage of 15 kV. Under these conditions, baseline separation of the four PALO stereoisomers was achieved within 35 min, and the reproducibility (expressed as relative standard deviation, RSD) of the migration times and the peak areas were below 0.5, 2.5% (intra-day), and 1.9, 4.4% (inter-day), respectively. hydrochloride, is a pharmacologically distinct and highly selective, secondgeneration 5-hydroxytryptamine type-3 (5-HT3) receptor antagonist approved for prevention of chemotherapy-and radiotherapy-induced nausea and vomit (CINV) after highly emetogenic chemotherapy. 1-4 Chemotherapy-and radiotherapyinduced nausea and vomit will have a series of related complications if they lack control; these are the most feared adverse reactions in cancer patients. 5-HT3 receptor antagonized mainly through competing to block the release of 5-HT and 5-HT3 receptor-binding of digestive tract mucosa in order to have a role in anti-vomit treatment.Chiral drugs include a large proportion of drugs at present; they generate different pharmacological effects through combining with different stereo structure molecules in the body in the processes of drug absorption, distribution, metabolism and excretion. Consequently, the separation and measurement of chiral drugs have great significance in the pharmacokinetics, pharmacological and toxicological mechanisms as well as in quality control of chiral drugs. Palonosetron hydrochloride contains two chiral centers and four stereoisomers: (3aR, 2R), (3aS, 2S), (3aR, 2S) and (3aS, 2R), among which only (3aS, 2S) possesses pharmacological activity. 5 Therefore, it is necessary to establish an appropriate enantiomeric separation method for PALO.Capillary electrophoresis (CE) is now recognized as a powerful tool for enantioseparation due to its high separation efficiency, low operational cost, simplicity and versatility. [6][7][8][9][10] In CE, the enantioselectivity is based on the chiral selector, which is dissolved in the running buffer. During the last decade, various types of chiral selectors, such as cyclodextrins (CDs) and their derivatives, 11,12 crown ethers, 13 chiral surfactants, 14,15 polysaccharides, 16,17 macrocyclic antibiotics, 18 proteins, 19 and metal complexes 20,21 have been widely used in CE. Among them, CDs and their various derivatives are the most popularly used chiral selectors with about 90% of the applications. 10 CDs, which obtained from amylum enzymatic conversion, can form inclusion compounds with many ...

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Section: Introductionmentioning

confidence: 99%

Enantioseparation of Palonosetron Hydrochloride by Capillary Zone Electrophoresis with High-concentration β-CD as Chiral Selector

et al. 2009

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“…Some examples of chiral selectors include: surfactant aggregates, CDs, crown ethers, and glycopeptides. Due to the vast exploration in this subject, numerous reviews detailing fundamentals and applications can be found in the literature prior to 2005 [6][7][8][9][10][11] and over the past two years [12][13][14][15]. Reviews have also covered methods developed specifically for pharmaceutical compounds [16][17][18][19][20][21][22], biological compounds [23], chiral LC-MS/ CE-MS [24], pesticides [25], pollutants [26], and food additives [27,28].…”

Section: Introductionmentioning

confidence: 99%

Review of aqueous chiral electrokinetic chromatography (EKC) with an emphasis on chiral microemulsion EKC

Kahle

Foley

2007

Electrophoresis

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Review of aqueous chiral electrokinetic chromatography (EKC) with an emphasis on chiral microemulsion EKCThe separation of enantiomers using electrokinetic chromatography (EKC) with chiral microemulsions is comprehensively reviewed through December 1, 2006. Aqueous chiral EKC separations based on other pseudostationary phases such as micelles and vesicles or on other chiral selectors such as CDs, crown ethers, glycopeptides, ligand exchange moeities are also reviewed from both mechanistic and applications perspective for the period of

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“…Therefore, chiral selectors carrying opposite charge to that of the selectands are very commonly utilized [7]. Several reviews have been published on the application of sulfated ␤-cyclodextrin (S-␤-CD) to the chiral CE [11,12].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous enantioseparation of antiparkinsonian medication Rotigotine and related chiral impurities by capillary zone electrophoresis using dual cyclodextrin system

Chu

Guo

Zuo

et al. 2008

Journal of Pharmaceutical and Biomedical Analysis

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Chiral Separations

Cited by 85 publications

References 218 publications

Enantioseparation of Palonosetron Hydrochloride by Capillary Zone Electrophoresis with High-concentration β-CD as Chiral Selector

Enantioseparation of Palonosetron Hydrochloride by Capillary Zone Electrophoresis with High-concentration β-CD as Chiral Selector

Review of aqueous chiral electrokinetic chromatography (EKC) with an emphasis on chiral microemulsion EKC

Simultaneous enantioseparation of antiparkinsonian medication Rotigotine and related chiral impurities by capillary zone electrophoresis using dual cyclodextrin system

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