Chiral separations in capillary high-performance liquid chromatography and nonaqueous capillary electrochromatography using helically chiral poly(diphenyl-2-pyridylmethyl methacrylate) as chiral stationary phase

Krause, Kerstin; Chankvetadze, Bezhan; Okamoto, Yoshio; Blaschke, Gottfried

doi:10.1002/(sici)1522-2683(19990901)20:13<2772::aid-elps2772>3.0.co;2-k

Cited by 62 publications

(23 citation statements)

References 23 publications

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“…No measurable contribution of poly(diphenyl-2-pyridylmethylmethacrylate) was observed in the overal EOF under the conditions reported in studies [59,62]. The same was true for vancomycin immobilized on silica diol [65].…”

Section: Content Of the Chiral Selector In The Cspmentioning

confidence: 62%

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Enantioseparations by capillary electrochromatography

et al. 2001

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The review summarizes recent developments in enantioseparations by capillary electrochromatography (CEC). Selected fundamental aspects of CEC are discussed in order to stress those features which may allow the success of this technique in the competitive field of enantioseparations. In addition, the comparative characteristics of the different modes of chiral CEC and the stationary phases are presented. The effects of the characteristics of the stationary and liquid phases and operational conditions on the separation results are discussed. Finally, some future trends are briefly addressed.

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Section: Content Of the Chiral Selector In The Cspmentioning

confidence: 62%

“…Some chiral selectors such as tert-butylcarbamoylquinine [33, 69±73], macrocyclic antibiotics [35, 64±68, 112, 113], poly(diphenyl-2-pyridylmethylmethacrylate) [59,62], etc. contain chargeable groups which may generate the EOF.…”

Section: Content Of the Chiral Selector In The Cspmentioning

confidence: 99%

Enantioseparations by capillary electrochromatography

et al. 2001

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“…Poly-N-acryloyl-l-phenylalanine ethylester covalently bound to silica (Chiraspher) [514] or a helically chiral poly(diphenyl-2-pyridylmethyl methacrylate) [519], which was coated to widepore aminopropyl-silanized silica, was used by Krause et al for chiral separations by capillary-HPLC and pressure-supported CEC.…”

Section: Packed Capillariesmentioning

confidence: 99%

Chiral separation by chromatographic and electromigration techniques. A Review

Gübitz

Schmid

2001

Biopharm & Drug Disp

227

135

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This review gives a survey of different chiral separation principles and their use in high-performance liquid chromatography (HPLC), gas chromatography (GC), supercritical fluid chromatography (SFC), thin-layer chromatography (TLC), capillary electrophoresis (CE) and capillary electrochromatography (CEC) highlighting new developments and innovative techniques. The mechanisms of the different separation principles are briefly discussed and some selected applications are shown.

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“…Enantiomer separation by NA-CEC was first described by Krause et al. [14,15] on a helically chiral poly(diphenyl-2-pyridylmethyl methacrylate stationary phase. Polysaccharidetype stationary phases such as cellulose tris(3,5-dimethylphenylcarbamate), amylose tris(3,5-dimethylphenylcarbamate), cellulose tris(4-methylbenzoate), and tris (3,5-dichlorophenylcarbamate) coated on silica were also suitable for chiral analysis by NA-CEC [12,13,16].…”

Section: Introductionmentioning

confidence: 99%

Enantiomer separation by nonaqueous and aqueous capillary electrochromatography on cyclodextrin stationary phases

2001

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Native beta- and gamma-cyclodextrin bound to silica (ChiraDex-beta and ChiraDex-gamma) were packed into capillaries and used for enantiomer separation by capillary electrochromatography (CEC) under aqueous and nonaqueous conditions. Negatively charged analytes (dansyl-amino acids) were resolved into their enantiomers by nonaqueous CEC (NA-CEC). The addition of a small amount of water to the nonaqueous mobile phase enhanced the enantioselectivity but increased the elution time. The choice of the background electrolyte (BGE) determined the direction of the electroosmotic flow (EOF). With 2-(N-morpholino) ethanesulfonic acid (MES) or triethylammonium acetate (TEAA) as BGE an inverse EOF (anodic EOF) was observed while with phosphate a cathodic EOF was found. The apparent pH (pH*), the concentration of the BGE, and the nature of the mobile phase strongly influenced the elution time, the theoretical plate number and the chiral separation factor of racemic analytes.

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Chiral separations in capillary high-performance liquid chromatography and nonaqueous capillary electrochromatography using helically chiral poly(diphenyl-2-pyridylmethyl methacrylate) as chiral stationary phase

Cited by 62 publications

References 23 publications

Enantioseparations by capillary electrochromatography

Enantioseparations by capillary electrochromatography

Chiral separation by chromatographic and electromigration techniques. A Review

Enantiomer separation by nonaqueous and aqueous capillary electrochromatography on cyclodextrin stationary phases

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