Chiral separations of β-blocking drug substances using the Pirkle-type α-Burke 1 chiral stationary phase

Petersen, Poul Vibholm; Ekelund, Jens; Olsen, Lars; Ovesen, Sanna Vinding

doi:10.1016/s0021-9673(96)00677-2

Cited by 28 publications

(2 citation statements)

References 5 publications

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“…The enantiomeric resolution can be obtained using a direct method on chiral stationary phase based on α-Glycoprotein or β-Cyclodextrin. The α-Glycoprotein is a protein wich has enantioselective properties and β-Cyclodextrin is an oligosaccharide with a cyclic structure, it is able to differentiate molecules of similar chemical structure, such as enantiomers [9][10].…”

Section: Introductionmentioning

confidence: 99%

Comparative Chiral Separation of (RS)‐Propranolol Racemate by HPLC Using α-Glycoprotein and β-Cyclodextrin Stationary Phases.

Matmour¹

2021

Alger. j. biosciences

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This paper describes a comparative study of tow chiral separations of (RS)‐Propranolol racemate by HPLC using α-Glycoprotein (AGP) and β-Cyclodextrin (BCD) Stationary Phases. For the AGP separation, the column size was (150 mm X4 mm X 5 μm), the mobile phase composed of Propanol-2 and Ammonium acetate (0.5:99.5 v/v), at a flow rate of 0.9 mL/min and the detection by ultraviolet absorption at 225 nm. For the BCD separation, the column size was (250 mm X4 mm X 5 μm), the mobile phase composed of Acetonitrile: Ethanol: Acetic acid: Triethylamine (960: 40: 4: 3 v/v/v/v), at a flow rate of 1 mL/min and the detection by ultraviolet absorption at 225 nm. The retention time of S-Propranolol and R-Propranolol with AGP separation was respectively: 7.25 min and 11.82 min while with the BCD separation 16.18 min and 18.50 min respectively. The racemate contains 50.46 % of S-Propranolol and 49.53 % of R-Propranolol with AGP separation while with BCD separation, it contains 50.43 %/49.57 %. There is a similarity between the enantiomeric purity values and the enantiomeric excess values of tow separations, but the separation with AGP stationary phase is faster than with the BCD stationary phase. For a selective β-blocking use, it could be very interesting to encourage its production in its form enantiomerically pure wich is the S-enantiomer.

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Section: Introductionmentioning

confidence: 99%

Comparative Chiral Separation of (RS)‐Propranolol Racemate by HPLC Using α-Glycoprotein and β-Cyclodextrin Stationary Phases.

Matmour¹

2021

Alger. j. biosciences

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“…CSPs are the preferred methods of chiral separation because of their high speed, sensitivity and reproducibility. Some commercially available CSPs for HPLC were used for the enantiomeric separation of 2-APA NSAIDs and b-blockers, such as polysaccharides, 2,5-12 b-cyclodextrin derivatives, 13 macrolide antibiotics, 14 proteins 15,16 and pirkle-type a-Burke 1 17 based CSPs. These CSPs were mostly limited to normal phase (NP) conditions, and relatively fewer were used under reverse phase (RP) conditions.…”

Section: Introductionmentioning

confidence: 99%

Enantiomeric separation of 2-arylpropionic acid nonsteroidal anti-inflammatory drugs and β-blockers by RP-HPLC using an amylose chiral stationary phase for the enantioselective skin permeation study

Zhang

Rong

et al. 2014

Anal. Methods

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Recent chromatographic and electrophoretic enantioseparations of cardiovascular drugs

Bojarşki

Aboul‐Enein

1999

Biomed. Chromatogr.

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Chiral separations of β-blocking drug substances using the Pirkle-type α-Burke 1 chiral stationary phase

Cited by 28 publications

References 5 publications

Comparative Chiral Separation of (RS)‐Propranolol Racemate by HPLC Using α-Glycoprotein and β-Cyclodextrin Stationary Phases.

Comparative Chiral Separation of (RS)‐Propranolol Racemate by HPLC Using α-Glycoprotein and β-Cyclodextrin Stationary Phases.

Enantiomeric separation of 2-arylpropionic acid nonsteroidal anti-inflammatory drugs and β-blockers by RP-HPLC using an amylose chiral stationary phase for the enantioselective skin permeation study

Recent chromatographic and electrophoretic enantioseparations of cardiovascular drugs

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