Chiral supernanostructures for ultrasensitive endonuclease analysis

Hao, Changlong; Kuang, Hua; Xu, Liguang; Liu, Liqiang; Ma, Wei; Wang, Libing

doi:10.1039/c3tb20985g

Cited by 17 publications

(14 citation statements)

References 44 publications

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“…The nucleic acid hybridization and antigen–antibody‐based immunorecognition are the two most sought out methods for constructing chiral active nanoassemblies. Based on these approaches, numerous chiral nanoassemblies consisting of chains, dimers, propeller‐like arrangements, and pyramid‐like structures have been developed for biosensing applications in cancer diagnosis . Here, we discuss some of the recently reported studies that describe the potential use of chiral nanobiosensors for early stage diagnosis of cancer.…”

Section: Nanomaterial‐based Cancer Sensing Systemsmentioning

confidence: 99%

Advanced Functional Structure‐Based Sensing and Imaging Strategies for Cancer Detection: Possibilities, Opportunities, Challenges, and Prospects

Kumar

Kukkar

Hashemi

et al. 2019

Adv Funct Materials

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Cancer is the second most common cause of death in the world. The principal limitations thus far encountered in the clinical practice of probing cancer are diverse and include low sensitivity, time consumption, bulkiness, and cost. In this respect, nanomaterial (NM)-based sensing techniques are recognized as a superior alternative to efficiently resolve such limitations. A better understanding of NM-based sensing platforms is thus important so that these novel avenues can easily be explored for clinical applications. These platforms have the merits of high sensitivity, high specificity, rapid response, and easy-to-read signals. This review offers a comprehensive survey of NM-based advanced cancer-sensing techniques and will help the scientific community establish optimum sensing strategies based on an accurate assessment of the interactions between cancer biomarkers and NM-based platforms.but are not limited to, carcinoma, sarcoma, leukemia, lymphoma, non-Hodgkin lymphoma, myeloma, central nervous system cancer, lung and bronchus cancer, colon cancer, rectum cancer, prostate cancer, bladder cancer, kidney and renal pelvis cancer, endometrial cancer, pancreatic cancer, liver cancer, and thyroid cancers. [1] Moreover, the most commonly occurring cancers tend to differ by common criteria like sex and age. For example, men are at risk for prostate, lung, and colorectal cancer, women are at risk for breast, lung and colorectal cancer, and children are at risk for leukemia, brain tumors, and lymphoma. The severity of the cancer depends upon the development level or staging of the disease. [2] Likewise, the type of treatment required to treat the cancer is determined by the staging of the disease.The more severe condition of cancer is metastasis, i.e., the uncontrolled growth of cells that invade surrounding tissues. The metastasis condition of cancer can affect any organ of the body. [3] As per the WHO 2010 report on cancer, the lives of 30% patients could have been saved if the cancer was diagnosed earlier. The detection of cancer is not easy because the immune system does not necessarily consider cancerous cells as foreign bodies. However, a few changes (such as altered biomarker levels and the presence of cancerous cells in biological fluids) can be detected. [4] In general, cancer biomarkers are overexpressed proteins present in blood/serum and at the cancer cell surface. The accurate and efficient detection of these biomarkers can be useful for cancer detection. The major problem with biomarkers is their low level in the body during the earlier stages of cancer. Hence, an efficient sensor/device capable of detecting these molecules even at very low levels, if developed, could help the clinician efficiently diagnose cancer cells in the human body.The sensing techniques presently used by clinicians suffer from several limitations; specifically, they are time consuming, bulky, have low sensitivity, and are expensive. Nanomaterial (NM)-based techniques have become an important alternative to the laborious conventional...

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Section: Nanomaterial‐based Cancer Sensing Systemsmentioning

confidence: 99%

Advanced Functional Structure‐Based Sensing and Imaging Strategies for Cancer Detection: Possibilities, Opportunities, Challenges, and Prospects

Kumar

Kukkar

Hashemi

et al. 2019

Adv Funct Materials

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“…The satellite nanostructure is advantageous over heterodimers because their surface can be easily functionalized with DNA. A pyramid of two different sizes of DNA‐Au nanoparticles constructed through hybridization was used for the detection of DNase I as shown in Figure a . DNase I is an important waste‐management endonuclease and is believed to be responsible for DNA fragmentation during apoptosis.…”

Section: Sensing Applicationsmentioning

confidence: 99%

“…a) Schematic description of the strategy for determining DNase I activity through an Au nanoparticle pyramid‐based CD assay. Reproduced with permission . Copyright 2013, Royal Society of Chemistry.…”

Section: Sensing Applicationsmentioning

confidence: 99%

“…Chiral nanoassebmlies can be composed of both chiral and non‐chiral nanoparticles, depending on their chiral geometry, while chiral nanocluster originates solely from chiral atomistic structures. The chiroptical properties of chiral assemblies may be from scissor‐like geometries, spatial configuration, or twisted structures for dimers, pyramids, and helices. The forces for forming chiral nanoassebmlies include Vander Waals forces, hydrogen bonds, and hydrophobic forces .…”

Section: Preparation Of Chiral Ag and Au Nanomaterialsmentioning

confidence: 99%

“…The chiroptical properties of chiral assemblies may be from scissor‐like geometries, spatial configuration, or twisted structures for dimers, pyramids, and helices. The forces for forming chiral nanoassebmlies include Vander Waals forces, hydrogen bonds, and hydrophobic forces . More importantly, the coupling or interaction of plasmon among nanoparticles always occurs, resulting in the formation of new CD signals 2g,42.…”

Section: Preparation Of Chiral Ag and Au Nanomaterialsmentioning

confidence: 99%

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Chiral Ag and Au Nanomaterials Based Optical Approaches for Analytical Applications

Xü

Lin

2019

Part & Part Syst Charact

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Sensing of chiral compounds has gained great attentions for many decades. Chiral nanomaterials with a greater surface area, optical properties, and stability have however not been well realized in this field. Herein, strategies for the preparation of chiral Ag and Au nanomaterials are focused upon, including Ag and Au nanoparticles conjugated with chiral molecules with/without containing fluorophores, chiral nanoassemblies of Ag and Au nanoparticles, and chiral Ag and Au nanoclusters. The chirality of nanomaterials originates from their core and/or ligand, meanwhile that for nanoassemblies results from their complex spatial configuration. An emphasis is given to circular dichroism, colorimetry/UV–vis absorption, and fluorescence detection modes for sensing enantiomers and achiral analytes using the chiral Ag and Au nanomaterials. Several interesting examples for quantitation of DNA, proteins, peptides, drugs, and pollutants are provided to highlight their potential as sensitive and selective nanomaterials for enantiomer recognition and sensing of achiral analytes. Several important issues to be solved when using chiral nanomaterials for chiral recognition are specified. Some strategies for improving the sensitivity and selectivity of chiral nanomaterials for chiral recognition are suggested. The aim is to bring more attention to the potential of chiral nanomaterials for sensing important analytes such as chiral drugs.

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