Chiral Symmetry Breaking in Peptide Systems During Formation of Life on Earth

Abstract

Chiral symmetry breaking in complex chemical systems with a large number of amino acids and a large number of similar reactions was considered. It was shown that effective averaging over similar reaction channels may result in very weak effective enantioselectivity of forward reactions, which does not allow most of the known models to result in chiral symmetry breaking during formation of life on Earth. Models with simple and catalytic synthesis of a single amino acid, formation of peptides up to length five, and sedimentation of insoluble pair of substances were considered. It was shown that depending on the model and the values of the parameters, chiral symmetry breaking may occur in up to about 10% out of all possible unique insoluble pair combinations even in the absence of any catalytic synthesis and that minimum total number of amino acids in the pair is 5. If weak enantioselective forward catalytic synthesis of amino acids is present, then the number of possible variants, in which chiral symmetry breaking may occur, increases substantially. It was shown that that the most interesting catalysts have zero or one amino acid of "incorrect" chirality. If the parameters of the model are adjusted in such a way to result in an increase of concentration of longer peptides, then catalysts with two amino acids of incorrect chirality start to appear at peptides of length five. Models of chiral symmetry breaking in the presence of epimerization were considered for peptides up to length three. It was shown that the range of parameters in which chiral symmetry breaking could occur significantly shrinks in comparison to previously considered models with peptides up to length two. An experiment of chiral symmetry breaking was proposed. The experiment consists of a three-step cycle: reversible catalytic synthesis of amino acids, reversible synthesis of peptides, and irreversible sedimentation of insoluble substances.

Homochirality: a prerequisite or consequence of life?

“…So the resulting model is also referred to as the APED model. A variant of this model was studied by Konstantinov & Konstantinova (2018).…”

Concentration–modulated global organizational chirality at the liquid/solid interface

“…Understanding how the enantiomerically pure structures emerged has attracted considerable attention. 1–5 Several theories such as the parity non-conservation of weak interaction and Salam's hypothesis have been proposed to elucidate how initial enantiomeric excess could have arisen from a probably racemic prebiotic world. However, their effects are very small, just acting as a trigger.…”