2023
DOI: 10.26434/chemrxiv-2023-f7qr8
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Chiral Trifluoromethylated Enamides: Synthesis and Applicability

Abstract: Enamides are valuable building blocks in organic synthesis that give access to complex nitrogen-containing compounds. However, despite their high interest, synthetic strategies to access enamides with carbon-centered chirality are scarce. Herein, we report a mild and robust synthetic method towards novel gamma-chiral, trifluoromethylated enamides from easily accessible alpha-chiral allylic amines through efficient chirality transfer (up to 99.5%) with excellent yields, diastereo- and enantioselectivities. A br… Show more

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