Chiral zirconia magnetic microspheres as a new recyclable selector for the discrimination of racemic drugs

Kumar, Avvaru Praveen; Kim, Jong Hwa; Thành, Trần Đăng; Lee, Yong‐Ill

doi:10.1039/c3tb20826e

Cited by 40 publications

(27 citation statements)

References 29 publications

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“…In the literature, chiral magnetic materials are primarily derived from small organic chiral compounds and nonhelical polymers. [38] In other words, the chirality in these chiral magnetic materials originates from configuration chirality (asymmetric molecular structures). We became more interested in chiral magnetic materials derived from synthetic helical polymers, due to the well-known chiral amplification effect.…”

Section: Optically Active Hybrid Materials Constructed From Hspa/fe 3mentioning

confidence: 99%

Optically Active Hybrid Materials Constructed from Helically Substituted Polyacetylenes

Huan-yu

Zhao

Deng

2016

The Chemical Record

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Functional materials derived from synthetic helical polymers are attracting increasing interest. Helically substituted polyacetylenes (HSPAs) are especially interesting as typical artificial helical polymers. In recent years, we designed and prepared a series of functional materials based on HSPAs and inorganic materials. The target is to establish some novel hybrid materials that combine the superior properties of both. The examined inorganic materials include silica, graphene, and magnetic Fe3 O4 nanoparticles. Such new functional materials hold great promise and are expected to find practical applications, for instance, as chiral absorbents, chiral sensors, chiral selectors for inducing enantioselective crystallization, chiral catalysts towards asymmetric catalysis, and chiral carriers for enantioselective release. The Personal Account summarizes our major achievements in preparing optically active hybrid materials. We hope it will speed up progress in chiral-related research areas.

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Section: Optically Active Hybrid Materials Constructed From Hspa/fe 3mentioning

confidence: 99%

Optically Active Hybrid Materials Constructed from Helically Substituted Polyacetylenes

Huan-yu

Zhao

Deng

2016

The Chemical Record

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“…Such CSP is suitable for the resolution of enantiomers of different racemic compounds, such as stereochemistry and aromatic compounds . The high column capacity makes it suitable for the preparation of enantiomers . Okamoto et al studied the resolution of 510 racemic compounds on cellulose tris‐(3, 5‐dimethylphenylcarbamate) CSP, with approximately 63% of the compounds being separated .…”

Section: Introductionmentioning

confidence: 99%

“…[25][26][27] The high column capacity makes it suitable for the preparation of enantiomers. 28,29 Okamoto et al studied the resolution of 510 racemic compounds on cellulose tris-(3, 5-dimethylphenylcarbamate) CSP, with approximately 63% of the compounds being separated. 30 Grieb et al used porous carbon as a carrier of cellulose-tris-(3, 5-dimethylphenylcarbamate) to prepare a CSP which showed a very good resolution for most of the analytes tested.…”

Section: Introductionmentioning

confidence: 99%

Cellulose type chiral stationary phase based on reduced graphene oxide@silica gel for the enantiomer separation of chiral compounds

Zhu

et al. 2018

Chirality

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The graphene oxide (GO) was covalently coupled to the surfaces of silica gel (SiO ) microspheres by amide bond to get the graphene oxide@silica gel (GO@SiO ). Then, the GO@SiO was reduced with hydrazine to the reduced graphene oxide@silica gel (rGO@SiO ), and the cellulose derivatives were physically coated on the surfaces of rGO@SiO to prepare a chiral stationary phase (CSP) for high performance liquid chromatography. Under the optimum experimental conditions, eight benzene-enriched enantiomers were separated completely, and the resolution of trans-stilbene oxide perfectly reached 4.83. Compared with the blank column of non-bonded rGO, the separation performance is better on the new CSP, which is due to the existence of rGO to produce special retention interaction with analytes, such as π-π stacking, hydrophobic effect, π-π electron-donor-acceptor interaction, and hydrogen bonding. Therefore, the obtained CSP shows special selectivity for benzene-enriched enantiomers, improves separation selectivity and efficiency, and rGO plays a synergistic effect with cellulose derivatives on enantioseparation.

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“…reported the synthesis of cellulose tris (3, 5‐dimethylphenylcarbamate) (CDMPC) modified Fe 3 O 4 @ZrO 2 magnetic materials. Experimental data demonstrated that the core‐shell materials thus‐prepared exhibited excellent chiral discrimination ability for some racemic drugs . With bovine serum albumin (BSA) anchored on the surface of Fe 3 O 4 particles, Li et al.…”

Section: Introductionmentioning

confidence: 99%

Facile synthesis and application of teicoplanin‐modified magnetic microparticles for enantioseparation

et al. 2017

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A facile, mild method for the preparation of teicoplanin (TE) modified Fe O microparticles (MPs) employing polydopamine (PDA) layer as a versatile secondary reaction platform was developed. The synthesized magnetic MPs (Fe O @PDA@TE) were characterized by various characterization techniques, such as TEM, zeta potential etc, to affirm the successful modification of TE to magnetic Fe O MPs. Using the as-synthesized materials as chiral adsorbents, efficient chiral separation of representative racemic compounds was successfully achieved. Due to the magnetic responsivity, the materials were easily isolated from the racemic solutions under an external magnetic field and could be readily reused for at least three times. Thus, the well-prepared functional magnetic MPs have great potential in preparative chiral separation.

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Chiral zirconia magnetic microspheres as a new recyclable selector for the discrimination of racemic drugs

Cited by 40 publications

References 29 publications

Optically Active Hybrid Materials Constructed from Helically Substituted Polyacetylenes

Optically Active Hybrid Materials Constructed from Helically Substituted Polyacetylenes

Cellulose type chiral stationary phase based on reduced graphene oxide@silica gel for the enantiomer separation of chiral compounds

Facile synthesis and application of teicoplanin‐modified magnetic microparticles for enantioseparation

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