Chirality detection of amino acid enantiomers by organic electrochemical transistor

Zhang, Lijun; Wang, Guiheng; Xiong, Can; Zheng, Lei; He, Jianbo; Ding, Yunsheng; Lu, Hongbo; Zhang, Guobing; Cho, Kilwon; Qiu, Longzhen

doi:10.1016/j.bios.2018.01.035

Cited by 81 publications

(39 citation statements)

References 53 publications

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“…Owing to the separable structure of the OECT devices, the gate electrode and channel can be fabricated individually and conveniently. Zhang et al [54] fabricated the OECT-based amino acid sensors in two steps. Firstly, the Au gate electrode was modified with L-Trp molecularly imprinted polymer (MIP) by cyclic voltammetry on an electrochemical workstation.…”

Section: Gate Surface As Sensing Interfacementioning

confidence: 99%

Functional Sensing Interfaces of PEDOT:PSS Organic Electrochemical Transistors for Chemical and Biological Sensors: A Mini Review

Liao

Zhang

et al. 2019

Sensors

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Organic electrochemical transistors (OECTs) are promising devices for applications in in vitro and in vivo measurements. OECTs have two important sensing interfaces for signal monitoring: One is the gate electrode surface; the other is the channel surface. This mini review introduced the new developments in chemical and biological detection of the two sensing interfaces. Specific focus was given on the modification technological approaches of the gate or channel surface. In particular, some unique strategies and surface designs aiming to facilitate signal-transduction and amplification were discussed. Several perspectives and current challenges of OECTs development were also briefly summarized.

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Section: Gate Surface As Sensing Interfacementioning

confidence: 99%

Functional Sensing Interfaces of PEDOT:PSS Organic Electrochemical Transistors for Chemical and Biological Sensors: A Mini Review

Liao

Zhang

et al. 2019

Sensors

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“…Such difficult goals can be achieved through a nanoarchitectonics approach, namely molecular imprinting [103–105]. Qiu and co-workers developed sensors for chirality detection of amino acid guests using an organic electrochemical transistor with a poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT/PSS) system modified with molecularly imprinted polymer films [106]. The selectivity factor of ʟ-tryptophan over ᴅ-tryptophan and that of ʟ-tyrosine over ᴅ-tyrosine were 11.6 and 14.5, respectively.…”

Section: Reviewmentioning

confidence: 99%

Review of advanced sensor devices employing nanoarchitectonics concepts

Ariga¹,

Makita²,

Watanabe³

et al. 2019

Beilstein J. Nanotechnol.

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Many recent advances in sensor technology have been possible due to nanotechnological advancements together with contributions from other research fields. Such interdisciplinary collaborations fit well with the emerging concept of nanoarchitectonics, which is a novel conceptual methodology to engineer functional materials and systems from nanoscale units through the fusion of nanotechnology with other research fields, including organic chemistry, supramolecular chemistry, materials science and biology. In this review article, we discuss recent advancements in sensor devices and sensor materials that take advantage of advanced nanoarchitectonics concepts for improved performance. In the first part, recent progress on sensor systems are roughly classified according to the sensor targets, such as chemical substances, physical conditions, and biological phenomena. In the following sections, advancements in various nanoarchitectonic motifs, including nanoporous structures, ultrathin films, and interfacial effects for improved sensor function are discussed to realize the importance of nanoarchitectonic structures. Many of these examples show that advancements in sensor technology are no longer limited by progress in microfabrication and nanofabrication of device structures – opening a new avenue for highly engineered, high performing sensor systems through the application of nanoarchitectonics concepts.

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“…Figure 3 (top) also includes the three cases of functionalization on the second cyclopentadienyl ring. While the presence of trialkylsilyl groups in 1' position (8,9) is practically unperceivable in respect to the parent case, consistent with a Hammett constant close to zero, a styrene group (7) results in a more positive reduction peak and a more negative oxidation peak (i. e. both easier oxidation and reduction), which can be justified in terms of a mesomeric effect as a result of extended conjugation, possibly also via π stacking. This might also explain the double peak system (see SI.2), which might account for two near-equivalent redox centers (i. e. the two styrene-cyclopentadienyl moieties) reciprocally interacting, although the presence of the electron attracting phosphane sulfide on one of the conjugated systems may also contribute to the potential difference.…”

Section: Reductionmentioning

confidence: 73%

Widening the Scope of “Inherently Chiral” Electrodes: Enantiodiscrimination of Chiral Electroactive Probes with Planar Stereogenicity

et al. 2020

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A series of planar‐stereogenicity ferrocenes, important as chiral promoters in enantioselective catalysis, is characterized in terms of relationships between structure and electronic properties. The enantiomers of six selected model cases are then successfully discriminated in voltammetry experiments on electrodes modified with electrodeposited inherently chiral oligomer films, in terms of significant potential differences, specular inverting probe or selector configuration. Small substituent changes do not alter the enantiomer peak sequence, but result in significant modulation of peak potential differences, which appear consistent with the availability of chiral/selector matching elements. The present stereogenic plane case, combined with former ones involving stereogenic centers, axes, and/or helices, shows that the inherent chirality strategy in electroanalysis can be effective with all four rigid stereogenic elements.

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Chirality detection of amino acid enantiomers by organic electrochemical transistor

Cited by 81 publications

References 53 publications

Functional Sensing Interfaces of PEDOT:PSS Organic Electrochemical Transistors for Chemical and Biological Sensors: A Mini Review

Functional Sensing Interfaces of PEDOT:PSS Organic Electrochemical Transistors for Chemical and Biological Sensors: A Mini Review

Review of advanced sensor devices employing nanoarchitectonics concepts

Widening the Scope of “Inherently Chiral” Electrodes: Enantiodiscrimination of Chiral Electroactive Probes with Planar Stereogenicity

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