Chirality-directed hydrogel assembly and interactions with enantiomers of an active pharmaceutical ingredient

Abstract

Enantiomers of the low-molecular-weight gelator (LMWG) DBS-CONHNH2, based on d- or l- 1,3:2,4-dibenzylidenesorbitol (DBS), form weaker gels when mixed, and encapsulate enantiomers of naproxen with a chiral preference.

Mimic enzymatic preparation of conductive supramolecular-polymeric hydrogels with antibacterial and antioxidant properties for accelerating wound healing

“…Drugs or other active small molecules could co-assemble with LMWG yielding nanofibrous hydrogels, thus realizing controlled release of drugs or other functions. [20][21][22][23][24] In our previous work, synthetic polymers were combined with DBSCOOH-diclofenac sodium co-assembled nanofibers via non-covalent or covalent interactions to fabricate mechanically enhanced DN supramolecular-polymeric composite hydrogels, thus achieving controlled release of diclofenac sodium and promoting wound healing. 17 Recently, a naturally derived guanosine (G)-based supramolecular hydrogel (namely G4 hydrogel) was fabricated via the self-assembly of G and KB (OH) 4 , which involves cation-templated formation of G-quartet motifs and nanofibrils.…”

Investigation of photoelectron elliptical dichroism for chiral analysis

“…However, since the start of this century a number of new chiroptical phenomena have been discovered with intrinsically larger signals which could allow more sensitive enantiomeric differentiation. These include microwave three wave mixing, 1–4 Coulomb explosion imaging, 5–7 along with photoion circular dichroism (PICD) 8–17 and photoelectron circular dichroism (PECD). 12,13,18–62…”

“…However, since the start of this century a number of new chiroptical phenomena have been discovered with intrinsically larger signals which could allow more sensitive enantiomeric differentiation. These include microwave three wave mixing, [1][2][3][4] Coulomb explosion imaging, [5][6][7] along with photoion circular dichroism (PICD) [8][9][10][11][12][13][14][15][16][17] and photoelectron circular dichroism (PECD). 12,13, PICD arises through the conventional absorption circular dichroism generated from excitation of an intermediate state, but PECD is manifested through the scattering of the photoelectron by the chiral molecular potential during ionization which generates a forward-backward asymmetry in the angular distribution.…”

An Exploration of Multiple Component Peptide Assemblies by Enzyme‐Instructed Self‐Assembly

“…Experimentation with peptide hydrogels is vast, which speaks to its ever‐growing list of examples and applications [6–40] . We reported the first use of an Fmoc based dipeptide which forms gels, and responds to a ligand‐receptor interaction [41] .…”