Chirality in Environmental Toxicity and Fate Assessments

Kallenborn, Roland; Hühnerfuß, Heinrich; Aboul‐Enein, Hassan Y.; Ali, Imran

doi:10.1007/978-3-030-62456-9_10

Cited by 2 publications

(1 citation statement)

References 218 publications

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“…In enantioselective recognition, intermolecular noncovalent interactions can be considered as the Pasteur’s tweezers that nature uses to let enantiorecognition occur at the molecular level, representing the basis for enantioselective drug action (including absorption, transport, and distribution in the living body, metabolism, pharmacokinetics, pharmacodynamics, and excretion), , enantioselective homogenous and heterogenous catalysis, − enantioselective transformation of chiral agrochemicals, pharmaceuticals and other compounds in nature (soil and aquatic systems), enantioselective sensing, , diastereomeric crystallization, , enzymatic catalytic transformation and resolution, and all enantioseparation techniques. − In other words, noncovalent interactions underlie all enantiorecognition processes occurring at the molecular level, representing a unifying fil rouge which goes across several disciplines of chemical, physical, biological, medical, and other natural sciences.…”

Section: Introductionmentioning

confidence: 99%

Recognition in the Domain of Molecular Chirality: From Noncovalent Interactions to Separation of Enantiomers

2022

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It is not a coincidence that both chirality and noncovalent interactions are ubiquitous in nature and synthetic molecular systems. Noncovalent interactivity between chiral molecules underlies enantioselective recognition as a fundamental phenomenon regulating life and human activities. Thus, noncovalent interactions represent the narrative thread of a fascinating story which goes across several disciplines of medical, chemical, physical, biological, and other natural sciences. This review has been conceived with the awareness that a modern attitude toward molecular chirality and its consequences needs to be founded on multidisciplinary approaches to disclose the molecular basis of essential enantioselective phenomena in the domain of chemical, physical, and life sciences. With the primary aim of discussing this topic in an integrated way, a comprehensive pool of rational and systematic multidisciplinary information is provided, which concerns the fundamentals of chirality, a description of noncovalent interactions, and their implications in enantioselective processes occurring in different contexts. A specific focus is devoted to enantioselection in chromatography and electromigration techniques because of their unique feature as “multistep” processes. A second motivation for writing this review is to make a clear statement about the state of the art, the tools we have at our disposal, and what is still missing to fully understand the mechanisms underlying enantioselective recognition.

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