Chitin and carbon nanotube composites as biocompatible scaffolds for neuron growth

Singh, Nandita; Chen, Jinhu; Kozioł, Krzysztof; Hallam, K; Janas, Dawid; Patil, Avinash J.; Strachan, Ally; Hanley, Jonathan G.; Rahatekar, Sameer S.

doi:10.1039/c5nr06595j

Cited by 69 publications

(33 citation statements)

References 52 publications

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“…[27][28][29][30][31][32][33][34][35][36][37][38] In addition, interests have also been generated to study the effects of nanoparticles on neurons and there are several reports that suggest that nanoparticles promote neuronal differentiation, and neuroprotection studied in both in vitro and in vivo conditions. 3,[39][40][41][42][43] To get better therapeutic results, various types of nanoparticles have been studied in neurons, and among those, carbon-based nanoparticles are mostly reported, 4,[44][45][46][47][48] followed by gold and silver nanoparticles (AgNPs). [49][50][51] Despite having many beneficial properties, nanoparticle also raises few health hazard and toxicity issues.…”

Section: Introduction Of Nanoparticlesmentioning

confidence: 99%

Impact of nanoparticles on neuron biology: current research trends

Khan

Almohazey

Alomari

et al. 2018

IJN

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Nanoparticles have enormous applications in textiles, cosmetics, electronics, and pharmaceuticals. But due to their exceptional physical and chemical properties, particularly antimicrobial, anticancer, antibacterial, anti-inflammatory properties, nanoparticles have many potential applications in diagnosis as well as in the treatment of various diseases. Over the past few years, nanoparticles have been extensively used to investigate their response on the neuronal cells. These nanoparticles cause stem cells to differentiate into neuronal cells and promote neuronal cell survivability and neuronal cell growth and expansion. The nanoparticles have been tested both in in vitro and in vivo models. The nanoparticles with various shapes, sizes, and chemical compositions mostly produced stimulatory effects on neuronal cells, but there are few that can cause inhibitory effects on the neuronal cells. In this review, we discuss stimulatory and inhibitory effects of various nanoparticles on the neuronal cells. The aim of this review was to summarize different effects of nanoparticles on the neuronal cells and try to understand the differential response of various nanoparticles. This review provides a bird’s eye view approach on the effects of various nanoparticles on neuronal differentiation, neuronal survivability, neuronal growth, neuronal cell adhesion, and functional and behavioral recovery. Finally, this review helps the researchers to understand the different roles of nanoparticles (stimulatory and inhibitory) in neuronal cells to develop effective therapeutic and diagnostic strategies for neurodegenerative diseases.

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Section: Introduction Of Nanoparticlesmentioning

confidence: 99%

Impact of nanoparticles on neuron biology: current research trends

Khan

Almohazey

Alomari

et al. 2018

IJN

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“…Some reports revealed ES could promote correct reinnervation and help axons cross the nerve repair site or nerve guidance channels, but it did not increase the speed of axonal elongation [44][45][46][47][48][49][50]. Besides, ES was believed to activate neuronal differentiation [35,51,52], and robust neuron regeneration was observed in vivo experiments on conductive materials with ES [53,54]. Recent studies found enhanced neurite outgrowth following ES [41,55].…”

Section: Discussionmentioning

confidence: 99%

Preparation of Multiwall Carbon Nanotubes Embedded Electroconductive Multi-Microchannel Scaffolds for Neuron Growth under Electrical Stimulation

Liu

Yushan

Alike

et al. 2020

BioMed Research International

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Objectives. To prepare the conductive MWCNT (multiwall carbon nanotube)-agarose scaffolds with multi-microchannel for neuron growth under electrical stimulation. Methods. The scaffolds were produced by gradient freeze and lyophilization methods. The synthesized materials were characterized by SEM and near-infrared spectroscopy, and their microstructure, swelling-deswelling, conductivity, biocompatibility, and shape memory behavior were measured. A three-dimensional culture model by implanting cells into scaffolds was built, and the behaviors of RSC96 cells on scaffolds under electrical stimulation were evaluated. Results. The addition of MWCNT did not affect the pore composition ratio and shape memory of agarose scaffolds, but 0.025% wt MWCNT in scaffolds improved the swelling ratio and water retention at the swelling equilibrium state. Though MWCNTs in high concentration had slight effect on proliferation of RSC96 cells and PC12 cells, there was no difference that the expressions of neurofilament of RSC96 cells on scaffolds with MWCNTs of different concentration. RSC96 cells arranged better along the longitudinal axis of scaffolds and showed better adhesion on both 0.025% MWCNT-agarose scaffolds and 0.05% MWCNT-agarose scaffolds compared to other scaffolds. Conclusions. Agarose scaffolds with MWCNTs possessed promising applicable prospect in peripheral nerve defects.

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“…Furthermore, the chitin can be modified to augment its electrical conductivity. Recently, the addition of carbon nanotubes to a chitin scaffold was shown to increase in electrical conductivity, synaptic function, and viability of engineered neurons [61]. …”

Section: Natural Polymersmentioning

confidence: 99%

Heterogeneity of Scaffold Biomaterials in Tissue Engineering

et al. 2016

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Tissue engineering (TE) offers a potential solution for the shortage of transplantable organs and the need for novel methods of tissue repair. Methods of TE have advanced significantly in recent years, but there are challenges to using engineered tissues and organs including but not limited to: biocompatibility, immunogenicity, biodegradation, and toxicity. Analysis of biomaterials used as scaffolds may, however, elucidate how TE can be enhanced. Ideally, biomaterials should closely mimic the characteristics of desired organ, their function and their in vivo environments. A review of biomaterials used in TE highlighted natural polymers, synthetic polymers, and decellularized organs as sources of scaffolding. Studies of discarded organs supported that decellularization offers a remedy to reducing waste of donor organs, but does not yet provide an effective solution to organ demand because it has shown varied success in vivo depending on organ complexity and physiological requirements. Review of polymer-based scaffolds revealed that a composite scaffold formed by copolymerization is more effective than single polymer scaffolds because it allows copolymers to offset disadvantages a single polymer may possess. Selection of biomaterials for use in TE is essential for transplant success. There is not, however, a singular biomaterial that is universally optimal.

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Chitin and carbon nanotube composites as biocompatible scaffolds for neuron growth

Abstract: General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms

Cited by 69 publications

References 52 publications

Impact of nanoparticles on neuron biology: current research trends

Impact of nanoparticles on neuron biology: current research trends

Preparation of Multiwall Carbon Nanotubes Embedded Electroconductive Multi-Microchannel Scaffolds for Neuron Growth under Electrical Stimulation

Heterogeneity of Scaffold Biomaterials in Tissue Engineering

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