Chitin Metabolism In Fungi

Dahiya, Neetu

doi:10.1007/978-90-481-3713-8_15

Cited by 1 publication

(1 citation statement)

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“…Subsequently, phosphate is transferred from C6 to C1 by the action of the enzyme phosphoacetylglucosamine mutase (termed Agm1 in Aspergillus spp. ), resulting in the formation of N-acetylglucosamine (GlcNAc)-1-phosphate [ 25 , 33 ]. Agm1 was shown to be an essential enzyme in A. fumigatus through the construction of a conditional mutant [ 34 ].…”

Section: Chitin Biosynthesismentioning

confidence: 99%

Chitin Biosynthesis in Aspergillus Species

Brauer

Pessoni

Freitas

et al. 2023

JoF

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The fungal cell wall (FCW) is a dynamic structure responsible for the maintenance of cellular homeostasis, and is essential for modulating the interaction of the fungus with its environment. It is composed of proteins, lipids, pigments and polysaccharides, including chitin. Chitin synthesis is catalyzed by chitin synthases (CS), and up to eight CS-encoding genes can be found in Aspergillus species. This review discusses in detail the chitin synthesis and regulation in Aspergillus species, and how manipulation of chitin synthesis pathways can modulate fungal growth, enzyme production, virulence and susceptibility to antifungal agents. More specifically, the metabolic steps involved in chitin biosynthesis are described with an emphasis on how the initiation of chitin biosynthesis remains unknown. A description of the classification, localization and transport of CS was also made. Chitin biosynthesis is shown to underlie a complex regulatory network, with extensive cross-talks existing between the different signaling pathways. Furthermore, pathways and recently identified regulators of chitin biosynthesis during the caspofungin paradoxical effect (CPE) are described. The effect of a chitin on the mammalian immune system is also discussed. Lastly, interference with chitin biosynthesis may also be beneficial for biotechnological applications. Even after more than 30 years of research, chitin biosynthesis remains a topic of current interest in mycology.

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Section: Chitin Biosynthesismentioning

confidence: 99%