Chitinase: a potent biocatalyst and its diverse applications

Mahajan, Gaytri; Sharma, Vibhuti; Gupta, Reena

doi:10.1080/10242422.2023.2218524

Cited by 9 publications

(1 citation statement)

References 169 publications

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“…Regarding chitin and chitosan depolymerization, these biopolymers can be specifically recognized by different glycosidase-type hydrolases present in nature, leading to different oligomeric structures, as depicted in Figure 3. Thus, chitinases [182,183] are enzymes which act on chitin following two types of mechanisms; on the one hand, endo-chitinases (EC 3.2.1.14) are enzymes which hydrolyze internal glycosidic bonds between GlcNAc subunits, producing various fragments with different sizes, ranging from dimers to polymers. Conversely, exo-chitinases (also named β-N-acetyl-glucosaminidases, EC 3.2.21.52) selectively hydrolyze chitin starting from either the reducing or non-reducing end, generating GlcNAc and, to lesser extent, dimeric (DP = 2) GlcNAc units.…”

Section: Biocatalysis For Chitin/chitosan Modificationsmentioning

confidence: 99%

Strategies to Prepare Chitin and Chitosan-Based Bioactive Structures Aided by Deep Eutectic Solvents: A Review

Durante-Salmerón,

Fraile-Gutiérrez,

Gil-Gonzalo

et al. 2024

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Chitin and chitosan, abundant biopolymers derived from the shells of crustaceans and the cell walls of fungi, have garnered considerable attention in pharmaceutical circles due to their biocompatibility, biodegradability, and versatile properties. Deep eutectic solvents (DESs), emerging green solvents composed of eutectic mixtures of hydrogen bond acceptors and donors, offer promising avenues for enhancing the solubility and functionality of chitin and chitosan in pharmaceutical formulations. This review delves into the potential of utilizing DESs as solvents for chitin and chitosan, highlighting their efficiency in dissolving these polymers, which facilitates the production of novel drug delivery systems, wound dressings, tissue engineering scaffolds, and antimicrobial agents. The distinctive physicochemical properties of DESs, including low toxicity, low volatility, and adaptable solvation power, enable the customization of chitin and chitosan-based materials to meet specific pharmaceutical requirements. Moreover, the environmentally friendly nature of DESs aligns with the growing demand for sustainable and eco-friendly processes in pharmaceutical manufacturing. This revision underscores recent advances illustrating the promising role of DESs in evolving the pharmaceutical applications of chitin and chitosan, laying the groundwork for the development of innovative drug delivery systems and biomedical materials with enhanced efficacy and safety profiles.

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Section: Biocatalysis For Chitin/chitosan Modificationsmentioning

confidence: 99%