Chitooligosaccharide supplementation improves the reproductive performance and milk composition of sows

Cheng, Likun; Wang, L.X.; Xu, Qingsong; Huang, Linjuan; Zhou, Dingpeng; Li, Z.; Li, S.G.; Du, Yuguang; Yin, Heng

doi:10.1016/j.livsci.2015.02.003

Cited by 29 publications

(32 citation statements)

References 28 publications

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“…Human milk is reported to contain more than 200 OS, whereas bovine milk or colostrum has up to 55 (Aldredge et al, 2013; Albrecht et al, 2014) and porcine milk 39 OS (Tao et al, 2010; Albrecht et al, 2014; Cheng et al, 2015). Porcine milk contains 2′-fu-cosyllactose and type I OS (LNT, lacto- N -fucopentaose I, lacto- N -fucopentaose II, lacto- N -difucohexose I) in higher abundance, whereas type II OS (whose core units are LNnT or LNnH, lacto- N -fucopentaose III) are present in lower abundances.…”

Section: Resultsmentioning

confidence: 99%

Characterization of porcine milk oligosaccharides during early lactation and their relation to the fecal microbiome

salcedo

Frese

Mills

et al. 2016

Journal of Dairy Science

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The composition of porcine milk oligosaccharides (PMO) was analyzed during early lactation and their relation to piglet gut microbiome was investigated. Pigs are considered ideal intestinal models to simulate humans because of the striking similarity in intestinal physiopathology to humans. The evolution of PMO was investigated in the milk from 3 healthy sows at prefarrowing, farrowing, and d 7 and 14 postpartum by Nano-LC Chip Quadrupole-Time-of-Flight mass spectrometer (Agilent Technologies, Santa Clara, CA). Previously sequenced metagenome libraries were reanalyzed to examine changes with specific gut bacterial populations. Over 30 oligosaccharides (OS) were identified in the milk, with 3′-sialyllactose, lacto-N-tetraose, α1–3,β1–4-d-galactotriose, 2′-fucosyllactose, and 6′-sialyllactose being the most abundant species (accounting for ~70% of the total OS). Porcine milk had lower OS diversity (number of unique structures) than human milk, and appeared closer to bovine and caprine milk. In agreement with previous studies, only 3 fucosylated OS were identified. Surprisingly, their contribution to total OS abundance was greater than in bovine milk (9 vs. 1%). Indeed, fucosylated PMO increased during lactation, mirroring a similar trend observed for neutral and type I OS content during early lactation. Taken together, these results suggest that, in terms of abundance, PMO are closer to human milk than other domestic species, such as bovine and caprine milks. Metagenomic sequencing revealed that fucose-consuming bacterial taxa in the gut microbiota of piglets were qualitatively but not quantitatively different between nursing and weaning stages, suggesting that both the composition and structure of dietary glycans may play a critical role in shaping the distal gut microbiome. The similarity of both intestinal physiopathology and milk OS composition in human and porcine species suggests similar effects on gastrointestinal development of early nutrition, reinforcing the use of the pig intestinal model to simulate human intestinal models in the clinical setting.

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Section: Resultsmentioning

confidence: 99%

Characterization of porcine milk oligosaccharides during early lactation and their relation to the fecal microbiome

salcedo

Frese

Mills

et al. 2016

Journal of Dairy Science

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“…Thus, reasonable nutritional supplementation for sows, especially in lactation, is crucial for enhancing offspring growth. Currently, dietary supplementation of COS provides a novel strategy to improve the reproductive performance of sows (Cheng et al 2015;Wan, Yang, et al 2016). However, further investigations are needed to clarify the connection between maternal COS supplementation during late gestation and lactation with offspring growth.…”

Section: Introductionmentioning

confidence: 99%

Maternal chitosan oligosaccharide supplementation during late gestation and lactation affects offspring growth

Wan

2018

Italian Journal of Animal Science

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Chitosan oligosaccharide (COS), a natural compound derived from chitin, has growth promotion property. However, the nature of the relationship between maternal COS supplementation and offspring growth is not yet understood. Therefore, we intended to determine the effects of maternal COS supplementation in late gestation and lactation on the offspring growth performance. Twenty-four pregnant Yorkshire sows were distributed into two equal groups (n ¼ 12) and fed either with a basal diet (control group) or a basal diet containing 100 mg/kg COS, from gestation day 85 until lactation day 21. Serum samples were collected from six sows of average body weight, from each group on farrowing day (lactation day 1) and lactation day 21, whereas colostrum and milk samples were respectively obtained on lactation days 1 and 21. We found that maternal COS supplementation significantly increased (p < .05) the average piglet weaning weight per litter. Supplementation of COS in the sow diet elevated (p < .05) the serum interleukin-10, immunoglobulin A (IgA) and IgM concentrations, as well as total antioxidant capacity. Moreover, higher (p < .05) colostrum IgM and milk lactose contents were simultaneously observed in COS-treated sows compared to the control sows. In summary, COS supplementation during late gestation and lactation can boost antioxidant capacity and humoural immunity of sows, and contributes to improving colostrum and milk quality, ultimately, enhancing the offspring growth performance. ARTICLE HISTORY

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“…Probiotics and prebiotics are added to infant formula to promote an intestinal microbiota resembling that of breastfed infants who have a greater concentration of bifidobacteria and less pathogenic bacteria than formula‐fed infants . Furthermore, reports have shown that addition of oligosaccharides to the diets of sows during late gestation and/or lactation increased milk production and improved the composition of colostrum and milk . Moreover, it was reported that maternal chitosan‐oligosaccharide supplementation increased the average piglet weaning weight per litter, and higher colostrum IgM and milk lactose concentrations were both observed in the chitosan‐oligosaccharide‐treated sows compared with those in the CON group .…”

Section: Discussionmentioning

confidence: 99%

“…As the only nutritional source for new born piglets, milk is crucial for their health. A recent study indicated that chitooligosaccharides supplementation modified milk composition . However, many studies have reported that single prebiotics play a small role in regulating intestinal health.…”

Section: Introductionmentioning

confidence: 99%

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Effects of dietary isomaltooligosaccharide and Bacillus spp. supplementation during perinatal period on lactational performance, blood metabolites, and milk composition of sows

Song

et al. 2019

J Sci Food Agric

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Background In this study, we evaluated the effects of isomaltooligosaccharide (IMO) and Bacillus spp. in perinatal diets on lactational performance, blood metabolites, and milk composition of sows. Multiparous gestating sows (N = 130) with similar body conditions were fed diets without containing IMO (control, CON group), IMO (IMO group), IMO and Bacillus subtilis (IMO + S group), IMO and Bacillus licheniformis (IMO + L group), and IMO and both B. subtilis and B. licheniformis (IMO + S + L group). Results The average daily feed intake of lactating sows in the IMO + S group (P < 0.05) and the average litter gain and total milk yield in the IMO + S + L group (P < 0.01) were significantly higher than those of the sows in the other treatment groups. In addition, the serum alanine aminotransferase and alkaline phosphatase concentrations in all treatment groups were lower than those in the CON group (P < 0.05). Furthermore, the highest proportion of fat in colostrum (0.05 < P < 0.1) and lowest proportion of lactose in milk were observed in the IMO + L group (P < 0.05). The concentrations of growth hormone and immunoglobulins A and G in milk were higher in sows supplemented with IMO, IMO + S, IMO + L, or IMO + S + L (P < 0.05). Conclusion IMO and Bacillus spp. supplementation during the perinatal period improved the sows' lactational performance by affecting their metabolism and milk quality. Sows in the IMO + S and IMO + S + L treatment groups exhibited the best performance. © 2019 Society of Chemical Industry

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Chitooligosaccharide supplementation improves the reproductive performance and milk composition of sows

Cited by 29 publications

References 28 publications

Characterization of porcine milk oligosaccharides during early lactation and their relation to the fecal microbiome

Characterization of porcine milk oligosaccharides during early lactation and their relation to the fecal microbiome

Maternal chitosan oligosaccharide supplementation during late gestation and lactation affects offspring growth

Effects of dietary isomaltooligosaccharide and Bacillus spp. supplementation during perinatal period on lactational performance, blood metabolites, and milk composition of sows

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