Chitooligosaccharide supplementation prevents the development of high fat diet-induced non-alcoholic fatty liver disease (NAFLD) in mice via the inhibition of cluster of differentiation 36 (CD36)

Zhao, Mengyao; Shen, Xin; Li, Xiaodan; Bao-li, Chen; Fan, Liqiang; Xia, Quanming; Zhao, Liming

doi:10.1016/j.jff.2019.03.048

Cited by 21 publications

(9 citation statements)

References 37 publications

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“…Studies have shown that the abnormally elevated expression of Cd36 is closely related to the formation of fatty liver. 53,57 In this study, high-dose common buckwheat intervention inhibited the uptake of NEFA by decreasing the high level of Cd36 in HFD-fed mice.…”

Section: ■ Discussionmentioning

confidence: 99%

“…As an important gene regulating the lipid uptake in hepatocytes, Cd36 is responsible for transferring LCFAs into hepatocytes and promoting the formation of high TGs in the blood. Studies have shown that the abnormally elevated expression of Cd36 is closely related to the formation of fatty liver. , In this study, high-dose common buckwheat intervention inhibited the uptake of NEFA by decreasing the high level of Cd36 in HFD-fed mice.…”

Section: Discussionmentioning

confidence: 99%

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Protective Mechanism of Common Buckwheat (Fagopyrum esculentum Moench.) against Nonalcoholic Fatty Liver Disease Associated with Dyslipidemia in Mice Fed a High-Fat and High-Cholesterol Diet

Huang

Deng

et al. 2020

J. Agric. Food Chem.

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This study aimed to investigate the protective mechanism of common buckwheat (Fagopyrum esculentum Moench.) against nonalcoholic fatty liver disease (NAFLD) associated with dyslipidemia in mice that were fed a high-fat and high-cholesterol diet (HFD). Results showed that oral supplementation of common buckwheat significantly improved physiological indexes and biochemical parameters related to dyslipidemia and NAFLD in mice fed with HFD. Furthermore, the HFD-induced reductions in fecal short-chain fatty acids were reversed by common buckwheat intervention, which also increased the fecal bile acid (BA) abundance compared with HFD-induced hyperlipidemic mice. Liver metabolomics based on ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry demonstrated that common buckwheat supplementation made significant regulatory effects on the pentose phosphate pathway, starch and sucrose metabolism, primary BA biosynthesis, and so forth. The results of high-throughput sequencing revealed that common buckwheat supplementation significantly altered the structure of the intestinal microbiota in mice fed with HFD. The correlations between lipid metabolic parameters and intestinal microbial phylotypes were also revealed by the heatmap and network. Additionally, common buckwheat intervention regulated the mRNA expressions of genes responsible for liver lipid metabolism and BA homeostasis, thus promoting BA synthesis and excretion. These findings confirmed that common buckwheat has the outstanding ability of improving lipid metabolism and could be used as a potential functional food for the prevention of NAFLD and hyperlipidemia.

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Section: ■ Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Protective Mechanism of Common Buckwheat (Fagopyrum esculentum Moench.) against Nonalcoholic Fatty Liver Disease Associated with Dyslipidemia in Mice Fed a High-Fat and High-Cholesterol Diet

Huang

Deng

et al. 2020

J. Agric. Food Chem.

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“…Studies showed that chitosan could significantly reduce the serum levels of TG, LDL and TC and in the liver of mice fed with a high-fat diet. It was shown to reduce the expression of CD36, PXR, DGAT2, LXR alpha and PPAR gamma, and to downregulate fatty acid uptake and TG synthesis as well as to lower the liver steatosis, consequently altering lipid accumulation [102]. Research by other authors showed that chitosan can significantly reduce TC, TG and LDL-C blood serum levels and increase the HDL-C blood serum levels in rats.…”

Section: Chitosanmentioning

confidence: 98%

Advances in the Study of Marine Products with Lipid-Lowering Properties

et al. 2020

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With twice the number of cancer’s deaths, cardiovascular diseases have become the leading cause of death worldwide. Atherosclerosis, in particular, is a progressive, chronic inflammatory cardiovascular disease caused by persistent damage to blood vessels due to elevated cholesterol levels and hyperlipidemia. This condition is characterized by an increase in serum cholesterol, triglycerides, and low-density lipoprotein, and a decrease in high-density lipoprotein. Although existing therapies with hypolipidemic effects can improve the living standards of patients with cardiovascular diseases, the drugs currently used in clinical practice have certain side effects, which insists on the need for the development of new types of drugs with lipid-lowering effects. Some marine-derived substances have proven hypolipidemic activities with fewer side effects and stand as a good alternative for drug development. Recently, there have been thousands of studies on substances with lipid-lowering properties of marine origin, and some are already implemented in clinical practice. Here, we summarize the active components of marine-derived products having a hypolipidemic effect. These active constituents according to their source are divided into algal, animal, plant and microbial and contribute to the development and utilization of marine medicinal products with hypolipidemic effects.

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“…Chitooligosaccharide (COS) is degraded mainly by enzymes from chitosan ( 52 ). Research inferred that COS could suppress the TLR4/NF-κB signaling pathway to protect against inflammation resulting from LPS and dextran sulfate sodium in IPEC-J2 cells and mice ( 53 ).…”

Section: Polysaccharidesmentioning

confidence: 99%

“…Lipid accumulation could be improved. The mechanism might be related to the inhibition of the mRNA and protein expression of a cluster of differentiation (CD)36, PXR, diacylglycerol acyltransferase-2, LXRα, and PPARγ ( 52 ). It was also reported that COS could promote the expression of not only the cholesterol-degrading enzyme cholesterol 7-α-hydroxylase but also incretin GLP-1 and suppress both HMGCR transcription and expression, which might especially restrain cholesterol synthesis.…”

Section: Polysaccharidesmentioning

confidence: 99%

Marine Natural Products and Coronary Artery Disease

Liang

Cai

2021

Front. Cardiovasc. Med.

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Coronary artery disease is the major cause of mortality worldwide, especially in low- and middle-income earners. To not only reduce angina symptoms and exercise-induced ischemia but also prevent cardiovascular events, pharmacological intervention strategies, including antiplatelet drugs, anticoagulant drugs, statins, and other lipid-lowering drugs, and renin–angiotensin–aldosterone system blockers, are conducted. However, the existing drugs for coronary artery disease are incomprehensive and have some adverse reactions. Thus, it is necessary to look for new drug research and development. Marine natural products have been considered a valuable source for drug discovery because of their chemical diversity and biological activities. The experiments and investigations indicated that several marine natural products, such as organic small molecules, polysaccharides, proteins, and bioactive peptides, and lipids were effective for treating coronary artery disease. Here, we particularly discussed the functions and mechanisms of active substances in coronary artery disease, including antiplatelet, anticoagulant, lipid-lowering, anti-inflammatory, and antioxidant activities.

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Chitooligosaccharide supplementation prevents the development of high fat diet-induced non-alcoholic fatty liver disease (NAFLD) in mice via the inhibition of cluster of differentiation 36 (CD36)

Cited by 21 publications

References 37 publications

Protective Mechanism of Common Buckwheat (Fagopyrum esculentum Moench.) against Nonalcoholic Fatty Liver Disease Associated with Dyslipidemia in Mice Fed a High-Fat and High-Cholesterol Diet

Protective Mechanism of Common Buckwheat (Fagopyrum esculentum Moench.) against Nonalcoholic Fatty Liver Disease Associated with Dyslipidemia in Mice Fed a High-Fat and High-Cholesterol Diet

Advances in the Study of Marine Products with Lipid-Lowering Properties

Marine Natural Products and Coronary Artery Disease

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