Chitosan – a promising biomaterial in veterinary medicine

Skin wounds are considered as the most critical, and widespread problems due to the high rate of accidents or burn worldwide. Full-thickness skin loss could be chronic or acute wounds, which found difficulty in medical treatment, because of taking a long time in healing. Therefore, exposure to the infection, which delays the healing process and causing disordered healing, ends with distortion or incomplete closure, which might lead to a fatal complication. Thus, the need for skin grafting is a necessary and critical decision although its side effects and rejection possibilities. This review put a spotlight on one of the latest therapeutic techniques in regenerative medicine "tissue engineering". It is an up-to-dates field in applications of stem cells and cells culture to replace the traditional tissue or organs transplantation techniques. We discussed the skin organ scaffolding as a simple example of tissue engineering applications in accelerating wound healing using stem cells cultured with chitosan scaffold. The latter is characterized by several medical properties especially in skin regeneration, for fabrication of artificial skin, which mimics the natural skin tissue and applying it in chronic or acute wounds therapy.

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“…In the veterinary field, biological membranes showed an important technical feature, as they can be used in non-clinical conditions [96].…”

Section: Skin Engineering Applications In Veterinary Medicinementioning

confidence: 99%

Tissue Engineering in Wound Healing Therapy by Using Chitosan and Stem Cells

El-Shaer

Abuel-Atta

Eid

et al. 2021

Zagazig Veterinary Journal

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“…Although recent studies indicated that a number of newly-developed chitosan formulations meet the criteria for good biomaterials characterized with unique antibacterial activity, non-allergic response, oxygen permeability, biodegradation to relatively neutral oligomers, unique ability to accelerate healing, functional flexibility, etc. [118], chitosan-based carriers have not been approved yet by the American Food and Drug Association (FDA) in the field of medical applications [48]. In this respect, The American Society of Testing Materials (ASTM F04 division IV) is making efforts to establish standard guidelines for chitosan salts suitable for use in biomedical or pharmaceutical applications, or both, including, but not limited to, tissue-engineered medical products (TEMPS).…”

Section: International/european Regulatory Aspects and Future Perspecmentioning

confidence: 99%

The 21st century revival of chitosan in service to bio-organic chemistry

Yaneva

Ivanova

Nikolova

et al. 2020

Biotechnology & Biotechnological Equipment

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The design and synthesis of biopolymer nano-and micro-formulations are a new trend with growing priority in scientific research and development in the fields of biomedicine, bioorganic/ medicinal chemistry, pharmaceutics, agrochemistry and food industry. This incorporates a vast variety of improved and newly-developed analytical and physico-chemical techniques for green and efficient synthesis. The scope of the present review was to outline the recent advances in the methods for design of novel chitosan micro-and nano-carriers and transporters. Special emphasis is laid on their functionalities and capacity for encapsulation of natural bioactive compounds and controlled in vitro/in vivo release in various biological/physiological media. Expectations for the application of chitosan formulations and chitosan-based hybrid systems are progressively increasing as the knowledge regarding their physical, chemical and biological properties constantly expands. Thus, this review proposes insights on the objective assessment of the capacity, applicability and versatility of newly-designed chitosan-based hybrid systems. A detailed integrative approach, which incorporates the innovative scientific achievements based on complex novel, precise and reliable analytical procedures and methods for qualitative and quantitative morphological, structural, spectral, chemical and biochemical analyses of the bioprecursors and the designed chitosan-carrier micro/nano-hybrid systems, is applied. Sustainable knowledge on the mechanism and methods of natural bioactive substances encapsulation and in vitro/in vivo release is reviewed and discussed.

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“…Generally, biomaterial's requirements can be grouped into four broad categories: biocompatibility, ability to be sterilized, functionality, and reproducibility 5 . Biomaterials can be used to manufacture contact lenses 1 , since they are defined as active substances capable of interaction with the surrounding tissue without causing an immune response 6 . Natural latex from the rubber tree, Hevea brasiliensis, is a raw material of high quality and durability, with biocompatible physical and chemical characteristics, antigenicity, hypoallergenicity, impermeability, elasticity, softness, flexibility, and low cost and resistance.…”

Section: Introductionmentioning

confidence: 99%

Development Assessment of Natural Latex Membranes: A New Proposal for the Treatment of Amblyopia

et al. 2017

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The ophthalmic dysfunction amblyopia, commonly known as lazy eye, is characterized by decreased vision in one eye due to improper development in childhood. The aim of this study was to obtain and characterize natural rubber membranes and to assess their utility as an eye film capable of altering the passage of light. The latex membranes were produced using the Van Gogh method and the deposition technique and were analyzed by physical and chemical methods to determine the properties of latex in natura and of natural rubber membranes. The materials were characterized by X-ray diffractometry, scanning electron microscopy, thermogravimetry, differential scanning calorimetry, analysis of water sorption and light crossing analysis. We report here a new approach to the treatment of patients with amblyopia using latex membranes.

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Chitosan – a promising biomaterial in veterinary medicine

Cited by 19 publications

References 40 publications

Tissue Engineering in Wound Healing Therapy by Using Chitosan and Stem Cells

Tissue Engineering in Wound Healing Therapy by Using Chitosan and Stem Cells

The 21st century revival of chitosan in service to bio-organic chemistry

Development Assessment of Natural Latex Membranes: A New Proposal for the Treatment of Amblyopia

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