Chitosan: A versatile biopolymer for orthopaedic tissue-engineering

Martino, Alberto Di; Sittinger, Michael; Risbud, Makarand V.

doi:10.1016/j.biomaterials.2005.03.016

Cited by 1,484 publications

(996 citation statements)

References 66 publications

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“…Many natural polymers including alginate [20] , agarose [21] , atelocollagen [22] , fibrin [23] , collagen [24] , chitosan [25] , and pectin [26] resulting in a gel structure [20,27] . Alginates are among the most frequently employed biomaterials for encapsulation due to their abundance, convenient gelling properties and high biocompatibility [28] .…”

Section: Ehd Compatible Biomaterialsmentioning

confidence: 99%

“…Chitosan is a linear polysaccharide composed of glucosamine and N-acetylglucosamine formed from the deacetylation of chitin, with the degree of deacetylation being directly proportional to cell attachment [25,30] . In addition to its cell compatibility, it has also been shown to exert an antibiotic effect and has demonstrated that it can be combined with antibiotics for sustained release maintaining clinical efficacy for three months [31] .…”

Section: Ehd Compatible Biomaterialsmentioning

confidence: 99%

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Living Cell Factories ‐ Electrosprayed Microcapsules and Microcarriers for Minimally Invasive Delivery

et al. 2015

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Minimally invasive delivery of "living cell factories" consisting of cells and therapeutic agents has gained wide attention for next generation biomaterial device systems for multiple applications including musculoskeletal tissue regeneration, diabetes and cancer. Cellularbased microcapsules and microcarrier systems offer several attractive features for this particular purpose. One such technology capable of generating these types of systems is electrohydrodynamic (EHD) spraying. Depending on various parameters including applied voltage, biomaterial properties (viscosity, conductivity) and needle geometry, complex structures and arrangements can be fabricated for therapeutic strategies. In this paper, we outline the advances in the use of EHD technology specifically in the manipulation of bioactive and dynamic material systems to control size, composition and configuration in the development of minimally invasive micro-scaled biopolymeric systems. The exciting therapeutic applications of this technology, future perspectives and associated challenges are also presented.

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Section: Ehd Compatible Biomaterialsmentioning

confidence: 99%

Section: Ehd Compatible Biomaterialsmentioning

confidence: 99%

Living Cell Factories ‐ Electrosprayed Microcapsules and Microcarriers for Minimally Invasive Delivery

et al. 2015

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“…Chitosan is a polysaccharide biopolymer composed of glucosamine and N-acetyl glucosamine units and is derived from partial de-acetylation of chitin (Di Martino et al, 2005;Roughley et al, 2006). Medical applications include wound haemostasis and healing, based on antimicrobial properties as well as drug delivery capabilities (Dai et al, 2011;Patel et al, 2010;Pusateri et al, 2003).…”

Section: Natural Hydrogels Chitosanmentioning

confidence: 99%

Biomaterials for intervertebral disc regeneration: past performance and possible future strategies

Schutgens¹,

Tryfonidou²,

Smit³

et al. 2015

eCM

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Intervertebral disc (IVD) degeneration is associated with most cases of cervical and lumbar spine pathologies, amongst which chronic low back pain has become the number one cause of loss of quality-adjusted life years. In search of alternatives to the current less than optimal and usually highly invasive treatments, regenerative strategies are being devised, none of which has reached clinical practice as yet. Strategies include the use of stem cells, gene therapy, growth factors and biomaterial carriers. Biomaterial carriers are an important component in musculoskeletal regenerative medicine techniques. Several biomaterials, both from natural and synthetic origin, have been used for regeneration of the IVD in vitro and in vivo. Aspects such as ease of use, mechanical properties, regenerative capacity, and their applicability as carriers for regenerative and anti-degenerative factors determine their suitability for IVD regeneration. The current review provides an overview of the biomaterials used with respect to these properties, including their drawbacks. In addition, as biomaterial application until now appears to have been based on a mix of mere availability and intuition, a more rational design is proposed for future use of biomaterials for IVD regeneration. Ideally, high-throughput screening is used to identify optimally effective materials, or alternatively medium content comparative studies should be carried out to determine an appropriate reference material for future studies on novel materials.

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“…Chitosan is a polysaccharide derived from chitin and is widely used in medicine as carriers for DDS and tissue-engineering scaffolds because of its useful characteristics such as biocompatibility, biodegradability, and cell-adhesion. 49,50 To produce chitosan beads with sizes of several hundred nanometers, simple precipitation processes are often employed. 51 Spray drier or vibration nozzle techniques have been reported for the production of chitosan hydrogel beads with sizes ranging from several micrometers to several millimeters.…”

Section: Production Of Chitosan Hydrogel Beadsmentioning

confidence: 99%

Microfluidic production of single micrometer-sized hydrogel beads utilizing droplet dissolution in a polar solvent

et al. 2013

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In this study, a microfluidic process is proposed for preparing monodisperse micrometer-sized hydrogel beads. This process utilizes non-equilibrium aqueous droplets formed in a polar organic solvent. The water-in-oil droplets of the hydrogel precursor rapidly shrunk owing to the dissolution of water molecules into the continuous phase. The shrunken and condensed droplets were then gelled, resulting in the formation of hydrogel microbeads with sizes significantly smaller than the initial droplet size. This study employed methyl acetate as the polar organic solvent, which can dissolve water at 8%. Two types of monodisperse hydrogel beads-Caalginate and chitosan-with sizes of 6-10 lm (coefficient of variation < 6%) were successfully produced. In addition, we obtained hydrogel beads with non-spherical morphologies by controlling the degree of droplet shrinkage at the time of gelation and by adjusting the concentration of the gelation agent. Furthermore, the encapsulation and concentration of DNA molecules within the hydrogel beads were demonstrated. The process presented in this study has great potential to produce small and highly concentrated hydrogel beads that are difficult to obtain by using conventional microfluidic processes. V C 2013 AIP Publishing LLC.

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Chitosan: A versatile biopolymer for orthopaedic tissue-engineering

Cited by 1,484 publications

References 66 publications

Living Cell Factories ‐ Electrosprayed Microcapsules and Microcarriers for Minimally Invasive Delivery

Living Cell Factories ‐ Electrosprayed Microcapsules and Microcarriers for Minimally Invasive Delivery

Biomaterials for intervertebral disc regeneration: past performance and possible future strategies

Microfluidic production of single micrometer-sized hydrogel beads utilizing droplet dissolution in a polar solvent

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