Chitosan and hydroxyapatite composite cross‐linked by dopamine has improved anisotropic hydroxyapatite growth and wet mechanical properties

Prajatelistia, Ekavianty; Lim, Chanoong; Oh, Dongyeop X.; Jun, Sang Ho; Hwang, Dong Soo

doi:10.1002/elsc.201400194

Cited by 16 publications

(5 citation statements)

References 45 publications

(75 reference statements)

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“…The reason for the decrease in hydrogel swelling and degradation rates is the same as mentioned above: the large number of active groups on PHA increased the cross‐linking density of the hydrogel, preventing excessive swelling of the hydrogels and delaying its degradation. Prajatelistia, Lim, Oh, Jun, and Hwang ()) used DA as an agent to cross‐link nHA and chitosan, and the results showed that the addition of DA reduced swelling in the presence of water, which is consistent with the results of our study. The swelling properties observed here are suitable for clinical applications, not only to fill the defect site but also to prevent harm from excessive spillover of the hydrogel material.…”

Section: Resultssupporting

confidence: 89%

The characteristics of mussel‐inspired nHA/OSA injectable hydrogel and repaired bone defect in rabbit

Liu¹,

Wu²,

Gan

et al. 2019

J Biomed Mater Res

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With the rapid development of minimally invasive techniques in orthopedics, minimally invasive surgery combined with injection of bone repair materials has attracted increasing attention for the treatment of bone defects. Inspired by material in mussels, we decorated nanohydroxyapatite (nHA) with dopamine (DA) to form polydopamine (PDA)-decorated nHA (PHA). Then, we introduced PHA into a Schiff base reaction of oxidized sodium alginate (OSA) and gelatin (Gel) to prepare an injectable bone repair hydrogel under mild conditions. Subsequently, the injectability, morphology, mechanical, swelling, and degradation properties of the hydrogel were studied. Then, bone marrow mesenchymal stem cells (BMSCs) were cocultured with the hydrogels to investigate the cytotoxicity, proliferation, and osteogenic differentiation properties of the hydrogel. Finally, the bone repair ability of the OSA-Gel-PHA hydrogels was explored using a 12 weeks rabbit bone defect model. The results of tube inversion and rheological test showed that the hydrogel gelation time was 3-7 min, which will be suitable for clinical operation. The results of SEM, compression tests, rheological tests, swelling and degradation properties tests showed that the addition of PHA changed the microstructure of the hydrogels from porous structure to layered structure, not only improved the compressive strength, toughness, elastic modulus, storage modulus of the hydrogels, but also reduced the swelling properties and degradation rate of the hydrogels, making it more conducive to clinical operations. The results of laser confocal, MTT assay, alkaline phosphatase (ALP) assay and in vivo animal experiments showed that the addition of PHA not only nontoxic, but also promoted the adhesion, proliferation and osteogenic differentiation of BMSCs, as well as the repair and maturation of bone. The application of injectable bone repair materials not only solves the problem of bone defect filling, but also avoids a series of complications caused by open surgery, providing new method for the treatment of bone defects.

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Section: Resultssupporting

confidence: 89%

The characteristics of mussel‐inspired nHA/OSA injectable hydrogel and repaired bone defect in rabbit

Liu¹,

Wu²,

Gan

et al. 2019

J Biomed Mater Res

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“…The pyrogallol group of GA binds to calcium ions in aqueous environments, which is a similar mechanism to catecholamines, which bind and enrich the interface with Ca 2+ , and this facilitates the precipitation of HAp crystals . Thus, GA/metal ion complex in the tubule was expected to accelerate a remineralized HAp in the presence of saliva.…”

Section: Resultsmentioning

confidence: 99%

Tunicate‐Inspired Gallic Acid/Metal Ion Complex for Instant and Efficient Treatment of Dentin Hypersensitivity

Prajatelistia

Sanandiya

et al. 2016

Adv Healthcare Materials

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Dentin hypersensitivity is sharp and unpleasant pains caused by exposed dentinal tubules when enamel outside of the tooth wears away. The occlusion of dentinal tubules via in situ remineralization of hydroxyapatite is the best method to alleviate the symptoms caused by dentin hypersensitivity. Commercially available dental desensitizers are generally effective only on a specific area and are relatively toxic, and their performance usually depends on the skill of the clinician. Here, a facile and efficient dentin hypersensitivity treatment with remarkable aesthetic improvement inspired by the tunicate-self-healing process is reported. As pyrogallol groups in tunicate proteins conjugate with metal ions to heal the torn body armor of a tunicate, the ingenious mechanism by introducing gallic acid (GA) as a cheap, abundant, and edible alternative to the pyrogallol groups of the tunicate combined with a varied daily intake of metal ion sources is mimicked. In particular, the GA/Fe(3+) complex exhibits the most promising results, to the instant ≈52% blockage in tubules within 4 min and ≈87% after 7 d of immersion in artificial saliva. Overall, the GA/metal ion complex-mediated coating is facile, instant, and effective, and is suggested as an aesthetic solution for treating dentin hypersensitivity.

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“…Bone mineralization involves HAp crystal deposition on a preexisting organic matrix consisting of type‐I collagen excreted from osteoblastic cells. Collagen aids crystal formation therein and acts as a support for ionic species, while HAp precipitates from aqueous solutions, as demonstrated by in vitro studies . Additionally, collagen obtained from demineralized bone grafted in combination with HAp is an excellent osteoinductive material .…”

Section: Introductionmentioning

confidence: 99%

Organic–inorganic collagen/iota‐carrageenan/hydroxyapatite hybrid membranes are bioactive materials for bone regeneration

Nogueira

Maniglia

Blácido

et al. 2019

J of Applied Polymer Sci

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This study aimed to produce biomembranes with controlled degradability for application in bone regeneration in order to stimulate biological reactions necessary to improve bone formation. Hydrogels were prepared by dissolving hydrolyzed collagen (HC) and iota‐carrageenan (ι‐Carr) in aqueous mixtures containing CaCl2 and H3PO4. A rise in pH by exposure to NH3(g) caused mineral precipitation into the hydrogel. Subsequently, the membranes were fabricated by solvent casting. Infrared spectroscopy and X‐ray diffraction attested hydroxyapatite formation. The crystallite size was close to 12 nm, which was smaller than the size reported for human bone apatite. The membranes induced bone‐like apatite precipitation in simulated body fluid. The carrageenan content modulated the membrane mechanical behavior. Membranes with controlled degradability were obtained by using higher amount of this polysaccharide. These membranes were able to release HC in physiological conditions. The surface properties were evaluated in terms of wettability and surface energy (γS) by means of contact angle (θc) measurements. Low θc (8.5–16.8) indicated that the hybrid membranes were hydrophilic, while higher γS values, around 70.6 mJ.m−2, could favor biomolecule incorporation into the surface. Our data set evidenced that these materials could potentially be used as a temporary guided tissue regeneration membrane with the possibility of inducing bone regeneration. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48004.

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Chitosan and hydroxyapatite composite cross‐linked by dopamine has improved anisotropic hydroxyapatite growth and wet mechanical properties

Cited by 16 publications

References 45 publications

The characteristics of mussel‐inspired nHA/OSA injectable hydrogel and repaired bone defect in rabbit

The characteristics of mussel‐inspired nHA/OSA injectable hydrogel and repaired bone defect in rabbit

Tunicate‐Inspired Gallic Acid/Metal Ion Complex for Instant and Efficient Treatment of Dentin Hypersensitivity

Organic–inorganic collagen/iota‐carrageenan/hydroxyapatite hybrid membranes are bioactive materials for bone regeneration

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