Chitosan and its derivatives: vectors in gene therapy

Functionalization of chitosan with carboxylic acids and derivatives of them: Synthesis issues and prospects of practical use: A review

“…(A similar mechanism of complex formation is also characteristic to other poly(acids) such as DNA, RNA, etc. [8], but this theme goes beyond the scope of the present review).…”

“…A. Farion 1 , V. F. Burdukovskii 1 , B. Ch. Kholkhoev 1,2* , P. S. Timashev 3,4 , R. K. Chailakhyan 4,5 diluted water solutions of monobasic mineral or organic acids with the formation of the polycations that prone to the formation of interpolymeric complexes with polyanionic macromolecules [7], including DNA and RNA [8]. By virtue of the chelating and electron-donating properties of the functional groups, chitosan forms readily complex compounds with the transition metals cations [9,10].…”

Polysaccharides in Ocular Drug Delivery

“…Natural polysaccharides are attractive options for the formulation of ocular medications, as these polysaccharides are economical, readily available, non-toxic, potentially biodegradable, generally biocompatible, and typically amenable to chemical modifications [8][9][10][11][12][13]. Indeed, chemical modifications have recently led to derivatives with improved properties in terms of rheology, mucoadhesion, increased ocular retention, and drug solubilization [14][15][16][17][18].…”

Biological Safety and Biodistribution of Chitosan Nanoparticles

“…Chitosan, the product of the complete or partial deacetylation of chitin, is a widely used excipient for topical or oral drug administration [1][2][3][4][5]. It is also now viewed as a useful material for the construction of drug and gene delivery systems for parenteral administration [1,[6][7][8][9][10][11]. The prospect of using chitosan as a carrier matrix for drug delivery emphasizes the importance of knowing the biological safety of chitosan dispersal systems.…”