Chitosan as Functional Biomaterial for Designing Delivery Systems in Cardiac Therapies

Patel, Bhaumik B.; Manne, Ravi; Patel, Dipal; Gorityala, Shashank; Palaniappan, Arunkumar; Kurakula, Mallesh

doi:10.3390/gels7040253

Cited by 30 publications

(17 citation statements)

References 85 publications

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“…Hydrogels based on CHT are gaining considerable interest for biomedical applications due to its biocompatibility, biodegradability, non-toxicity, and biological features, such as bio-adhesiveness, antibacterial, hemostatic, and anti-inflammatory properties. Altogether, these properties are pivotal in the design of biomedical systems for smart drug delivery [ 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 ], wound healing [ 136 ], and regenerative medicine [ 137 ].…”

Section: Chitosan-based Hydrogels For Biomedical Applicationsmentioning

confidence: 99%

Chitosan-Based Biomaterials: Insights into Chemistry, Properties, Devices, and Their Biomedical Applications

et al. 2023

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Chitosan is a marine-origin polysaccharide obtained from the deacetylation of chitin, the main component of crustaceans’ exoskeleton, and the second most abundant in nature. Although this biopolymer has received limited attention for several decades right after its discovery, since the new millennium chitosan has emerged owing to its physicochemical, structural and biological properties, multifunctionalities and applications in several sectors. This review aims at providing an overview of chitosan properties, chemical functionalization, and the innovative biomaterials obtained thereof. Firstly, the chemical functionalization of chitosan backbone in the amino and hydroxyl groups will be addressed. Then, the review will focus on the bottom-up strategies to process a wide array of chitosan-based biomaterials. In particular, the preparation of chitosan-based hydrogels, organic–inorganic hybrids, layer-by-layer assemblies, (bio)inks and their use in the biomedical field will be covered aiming to elucidate and inspire the community to keep on exploring the unique features and properties imparted by chitosan to develop advanced biomedical devices. Given the wide body of literature that has appeared in past years, this review is far from being exhaustive. Selected works in the last 10 years will be considered.

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Section: Chitosan-based Hydrogels For Biomedical Applicationsmentioning

confidence: 99%

Chitosan-Based Biomaterials: Insights into Chemistry, Properties, Devices, and Their Biomedical Applications

et al. 2023

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“…Chitosan’s positive charge and hydrophilicity, among other properties, enable the development of a soft tissue milieu, particularly when combined with biomolecules. Scaffolds made of chitosan support stem cell proliferation and differentiation by providing mechanical strength ( Patel et al, 2021 ).…”

Section: Bone Tissue Engineeringmentioning

confidence: 99%

Stimuli-responsive injectable chitosan-based hydrogels for controlled drug delivery systems

Garshasbi

Salehi²,

Naghib³

et al. 2023

Front. Bioeng. Biotechnol.

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In the last decade, injectable hydrogels have attracted a lot of attention due to their excellent functional properties in the field of drug delivery for precise, non-invasive and focused tissue locations. Therefore, designing drug delivery systems (DDS) responsive to hydrogel stimuli to release a drug to an external stimulus with various advantages, can be very challenging. Due to their biocompatibility, mucosal adhesion, and hemostatic activity, chitosan (Chitosan)-based hydrogels offer a lot of potential for tissue engineering and drug delivery. It can be difficult to manage the structure of these stimuli-responsive CS hydrogels or they may require additional crosslinking agents, such as hydrogels with dual pH and thermo-responsiveness. Therefore, it is crucial to create these hydrogels for medicinal applications.

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“…When fibers are incorporated, the strength and stiffness of the scaffold can be improved. The effects of 2 mm fibers were up to three times greater than those of 10 mm fibers at identical mass ratios [ 56 , 57 , 58 ].…”

Section: Scaffoldsmentioning

confidence: 99%

Artificial Scaffolds in Cardiac Tissue Engineering

Roacho-Pérez

Garza-Treviño

Moncada‐Saucedo

et al. 2022

Life

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Cardiovascular diseases are a leading cause of death worldwide. Current treatments directed at heart repair have several disadvantages, such as a lack of donors for heart transplantation or non-bioactive inert materials for replacing damaged tissue. Because of the natural lack of regeneration of cardiomyocytes, new treatment strategies involve stimulating heart tissue regeneration. The basic three elements of cardiac tissue engineering (cells, growth factors, and scaffolds) are described in this review, with a highlight on the role of artificial scaffolds. Scaffolds for cardiac tissue engineering are tridimensional porous structures that imitate the extracellular heart matrix, with the ability to promote cell adhesion, migration, differentiation, and proliferation. In the heart, there is an important requirement to provide scaffold cellular attachment, but scaffolds also need to permit mechanical contractility and electrical conductivity. For researchers working in cardiac tissue engineering, there is an important need to choose an adequate artificial scaffold biofabrication technique, as well as the ideal biocompatible biodegradable biomaterial for scaffold construction. Finally, there are many suitable options for researchers to obtain scaffolds that promote cell–electrical interactions and tissue repair, reaching the goal of cardiac tissue engineering.

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Chitosan as Functional Biomaterial for Designing Delivery Systems in Cardiac Therapies

Cited by 30 publications

References 85 publications

Chitosan-Based Biomaterials: Insights into Chemistry, Properties, Devices, and Their Biomedical Applications

Chitosan-Based Biomaterials: Insights into Chemistry, Properties, Devices, and Their Biomedical Applications

Stimuli-responsive injectable chitosan-based hydrogels for controlled drug delivery systems

Artificial Scaffolds in Cardiac Tissue Engineering

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