Chitosan-based bioglass composite for bone tissue healing : Oxidative stress status and antiosteoporotic performance in a ovariectomized rat model

Jebahi, Samira; Oudadesse, Hassane; Saleh, Gada Ben; Saoudi, Mongi; Mesadhi, Sirrar; Rebaï, Tarek; Keskes, Hassib; Feki, Abdelfattah El; Feki, Hafed El

doi:10.1007/s11814-014-0072-9

Cited by 21 publications

(12 citation statements)

References 20 publications

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“…Chitosan is available in a variety of forms, including beads, films, hydrogels, and more complex structures, such as porous scaffolds ( Table 1 ). Due to the poor mechanical properties exhibited by chitosan, it is often combined with other materials such as gelatin, calcium phosphates and bioglass to provide more desirable properties [ 54 , 55 , 56 , 57 ]. Wattanutchariya and Changkowkai found that mixing chitosan with gelatin and hydroxyapatite (HA) produces a porous scaffold with more desirable properties, including decreased degradability and an open pore structure conducive to cell attachment and vascularization [ 58 ].…”

Section: Classification Of Dental Bone Graft and Substitute Materialsmentioning

confidence: 99%

Bone Grafts and Substitutes in Dentistry: A Review of Current Trends and Developments

et al. 2021

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After tooth loss, bone resorption is irreversible, leaving the area without adequate bone volume for successful implant treatment. Bone grafting is the only solution to reverse dental bone loss and is a well-accepted procedure required in one in every four dental implants. Research and development in materials, design and fabrication technologies have expanded over the years to achieve successful and long-lasting dental implants for tooth substitution. This review will critically present the various dental bone graft and substitute materials that have been used to achieve a successful dental implant. The article also reviews the properties of dental bone grafts and various dental bone substitutes that have been studied or are currently available commercially. The various classifications of bone grafts and substitutes, including natural and synthetic materials, are critically presented, and available commercial products in each category are discussed. Different bone substitute materials, including metals, ceramics, polymers, or their combinations, and their chemical, physical, and biocompatibility properties are explored. Limitations of the available materials are presented, and areas which require further research and development are highlighted. Tissue engineering hybrid constructions with enhanced bone regeneration ability, such as cell-based or growth factor-based bone substitutes, are discussed as an emerging area of development.

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Section: Classification Of Dental Bone Graft and Substitute Materialsmentioning

confidence: 99%

Bone Grafts and Substitutes in Dentistry: A Review of Current Trends and Developments

et al. 2021

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“…[34] Chitosan-doped bioactive glass has also osteogenic capacity and antioxidant activity against free radicals. [35] It has been demonstrated that protein adsorption and cell attachment increased by the addition of bioactive glass to chitosan. [18] Finally, although various compounds of these three mentioned materials had been widely used in the forms of scaffold, [36] injectable paste, [37] and foam-like materials, some of their properties such as rheological behavior and bioactivity are yet unclear and need more work.…”

Section: Introductionmentioning

confidence: 99%

Rheology, injectability, and bioactivity of bioactive glass containing chitosan/gelatin, nano pastes

Sohrabi

Yekta

Rezaie

et al. 2020

J of Applied Polymer Sci

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Bioactive pastes containing bioactive sol–gel derived glass (BG) and various amounts of chitosan (Cn) and gelatin (Gel) were prepared in this study. To be exact, three pastes were prepared by mixing 25 parts by weight of glass powder with (a) 100 parts by weight of a 3 wt% acetic acid‐based chitosan solution, (b) 100 parts by weight of a 3 wt% water‐based gelatin solution, and (c) 100 parts by weight of a solution containing equal amounts of the above‐mentioned solutions. The bioactivity of the composite samples was evaluated by the immersion of the prepared pastes into the simulated body fluid (SBF) solution. The samples were also analyzed by X‐ray diffractometry (XRD), Brunauer–Emmett–Teller (BET), scanning electron microscope (SEM), Fourier transform infrared (FTIR), and atomic absorption spectroscopy (AAS). The results indicated better apatite formation capacity on the glass‐/chitosan‐/gelatin‐injected paste after 14 days. Furthermore, unlike the chitosan containing paste, the gelatin‐containing sample was injectable and displayed viscoelastic behavior as determined by conducting the rheology test in oscillation mode. In addition, while chitosan made the paste more viscous, it improved the washout resistance when compared to the gelatin‐containing sample. The experimental results also indicate the formation of spherical calcites in the pastes prior to immersion into the SBF solution.

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“…Our previous works have been based on the preparation of bioactive composite glass and chitosan biopolymer (17%) by the freeze‐drying process. Through their in vivo experiments, we studied its antioxidative performance and its effect of the generated porosity in the resorption and in the osseointegration of the obtained bio composite (Bui, Oudadesse, Le Gal, Merdrignac‐Conanec, & Cathelineau, 2012; Jebahi et al, 2014; Oudadesse et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Development of hybrid scaffold: Bioactive glass nanoparticles/chitosan for tissue engineering applications

Oudadesse

Najem

Mosbahi

et al. 2020

J Biomedical Materials Res

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Bone tissue engineering is gaining popularity as an alternative method for the treatment of osseous defects. A number of biodegradable polymers have been explored for tissue engineering purposes. A new family of biodegradable polymer/bioactive glass composite materials has been designed to be used in bone regeneration approaches. In this work, a hybrid scaffold of chitosan (CH) and bioactive glass nanoparticles (BGN) was prepared by the freeze‐gelation method. This method has been studied by adjusting the concentration of acetic acid; this process can influence the structure properties of the scaffold. In this work, several BGN/CH composites have been prepared by varying the proportion of BGN in the hybrid scaffold (20, 40, 60, and 80%). Brunauer–Emmett–Teller results showed the increased surface area and porosity volume of our composite with decreasing BGN proportion. BGN/CH hybrid scaffold was characterized by using physicochemical techniques. Obtained results showed a macroporous morphology of the scaffold with a pore size of about 200 μm, and a homogeneous distribution of the BGN in the CH matrix. X‐ray diffraction study confirmed the amorphous state of the BGN/CH hybrid scaffold. Interaction between CH and BGNs in the composite was confirmed. The in vitro assays showed adequate degradation properties, which is essential for the potential replacement by the new tissue. The in vitro bioactivity studies confirmed the formation of an apatite layer on the surface of the hybrid scaffold, which results in a direct bone bonding of the implant. These results indicate that BGN/CH hybrid scaffold developed is a potential candidate for bone tissue engineering.

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Chitosan-based bioglass composite for bone tissue healing : Oxidative stress status and antiosteoporotic performance in a ovariectomized rat model

Cited by 21 publications

References 20 publications

Bone Grafts and Substitutes in Dentistry: A Review of Current Trends and Developments

Bone Grafts and Substitutes in Dentistry: A Review of Current Trends and Developments

Rheology, injectability, and bioactivity of bioactive glass containing chitosan/gelatin, nano pastes

Development of hybrid scaffold: Bioactive glass nanoparticles/chitosan for tissue engineering applications

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