Chitosan-based drug nanocarriers: Where do we stand?

García-Fuentes, Marcos; Alonso, Marı́a José

doi:10.1016/j.jconrel.2012.03.017

Cited by 315 publications

(193 citation statements)

References 152 publications

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“…CS has been widely used to prepare nanocarriers such as micelles and nanoparticles. 8 Nanoparticles based on CS and its derivatives, such as N-trimethyl CS (TMC), could enhance the oral bioavailability of encapsulated drugs by opening tight junctions in intestinal epithelial cells. 9 Coating of anionic liposomes with CS and its derivatives via electrical attraction may result in charge reversal on their surface.…”

Section: Introductionmentioning

confidence: 99%

Liposomes coated with N-trimethyl chitosan to improve the absorption of harmine in vivo and in vitro

Chen¹,

Yuan²,

Liu³

et al. 2016

IJN

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In this study, harmine liposomes (HM-lip) were prepared through the thin-film hydration–pH-gradient method and then coated with N -trimethyl chitosan (TMC). Particle size, zeta potential, entrapment efficiency, and in vitro release of HM-lip and TMC-coated harmine liposomes (TMC-HM-lip) were also determined. Sprague Dawley rats were further used to investigate the pharmacokinetics in vivo. Retention behavior in mouse gastrointestinal tract (GIT) was studied through high-performance liquid chromatography and near-infrared imaging. Degradation was further evaluated through incubation with Caco-2 cell homogenates, and a Caco-2 monolayer cell model was used to investigate the uptake and transport of drugs. HM-lip and TMC-HM-lip with particle size of 150–170 nm, an entrapment efficiency of about 81%, and a zeta potential of negative and positive, respectively, were prepared. The release of HM from HM-lip and TMC-HM-lip was slower than that from HM solution and was sensitive to pH. TMC-HM-lip exhibited higher oral bioavailability and had prolonged retention time in GIT. HM-lip and TMC-HM-lip could also protect HM against degradation in Caco-2 cell homogenates. The uptake amount of TMC-HM-lip was higher than that of HM and HM-lip. TMC-HM-lip further demonstrated higher apparent permeability coefficient ( P app ) from the apical to the basolateral side than HM and HM-lip because of its higher uptake and capability to open tight junctions in the cell monolayers. TMC-HM-lip can prolong the retention time in the GIT, protect HM against enzyme degradation, and improve transport across Caco-2 cell monolayers, thus enhancing the oral bioavailability of HM.

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Section: Introductionmentioning

confidence: 99%

Liposomes coated with N-trimethyl chitosan to improve the absorption of harmine in vivo and in vitro

Chen¹,

Yuan²,

Liu³

et al. 2016

IJN

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“…Hermida et al recently prepared chitosan containing liposomes that demonstrated high iron loading and iron absorption in Caco-2 cells. Chitosan is a naturally occurring polysacchride that has been well characterised and studied extensively for drug delivery applications [26,27]. Chitosan is widely used in dietary supplement preparations, has a well established safety profile, and has Food & Drug Administration (FDA) approval for use in food applications [28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Ascorbyl palmitate/DSPE-PEG nanocarriers for oral iron delivery: Preparation, characterisation and in vitro evaluation

Zariwala

Farnaud

Merchant

et al. 2014

Colloids and Surfaces B: Biointerfaces

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“…Furthermore, after surface crosslinking with genipin (a nontoxic cross-linking reagent from gardenia fruits), the chitosan-CPP nanoparticles can withstand the harsh pH and digestion enzyme conditions in gastrointestinal fluids. The release of EGCG is dependent on the degradation of chitosan chains by a number of enzymes in human serum and cells, and it could be regulated through adjusting the extent of crosslinking (23). These nanoparticles are nontoxic and could complement SLNs in the delivery of polar and charged molecules.…”

Section: Oral Delivery Of Nanoparticlesmentioning

confidence: 99%

Combination of Chemopreventive Agents in Nanoparticles for Cancer Prevention

Yang

Wang

2013

Cancer Prevention Research

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Carcinogenesis involves multiple genetic and epigenetic alterations, and a single chemopreventive agent may not be sufficient to prevent these events. Therefore, the use of a combination of agents is an attractive approach for cancer chemoprevention. In this issue of the journal, Prabhu and colleagues examined a combination of aspirin, curcumin, and sulforaphane for the prevention of pancreatic cancer in hamsters (beginning page 1015). The novelty of this work is that when aspirin and curcumin were incorporated in nanoparticles and administered orally, in combination with sulforaphane, the effective dosages were decreased by 10-fold in comparison with the free form mixture. In this commentary, the possible mechanisms of synergistic action among multiple chemopreventive agents and the use of stable nanoparticles for oral delivery are discussed. Also discussed is the importance of measuring tissue levels of the chemopreventive agents to understand the mode of action of these nanoparticles and to avoid toxicity.

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Chitosan-based drug nanocarriers: Where do we stand?

Cited by 315 publications

References 152 publications

Liposomes coated with N-trimethyl chitosan to improve the absorption of harmine in vivo and in vitro

Liposomes coated with N-trimethyl chitosan to improve the absorption of harmine in vivo and in vitro

Ascorbyl palmitate/DSPE-PEG nanocarriers for oral iron delivery: Preparation, characterisation and in vitro evaluation

Combination of Chemopreventive Agents in Nanoparticles for Cancer Prevention

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