Chitosan-Based Films Containing Rutin for Potential Cosmetic Applications

Abstract

Chitosan is a polysaccharide with film-forming properties. Such properties are widely used for the preparation of beauty masks and wound-healing materials. In this work, chitosan-based films containing hyaluronic acid and rutin have been researched for potential cosmetic applications. Rutin was added to a chitosan solution in lactic acid, and then thin films were fabricated. The structure of the films was studied using FTIR spectroscopy. Surface properties were studied using an AFM microscope. The release of rutin from chitosan-based film was researched by the HPLC method. The properties of the skin, such as elasticity and moisturization, were studied using the Aramo TS 2 apparatus. It was found that the addition of rutin did not have an influence on the chitosan structure but affected its thermal stability. The roughness of the films was bigger after the addition of rutin to chitosan-based films. Skin elasticity and skin moisturization were somewhat improved after the topical application of the proposed chitosan–rutin mask. The maximum release of rutin was found after 20 min at pH 5.5, related to the pH of normal human skin. The average percentage of release from chitosan-based film containing hyaluronic acid was smaller than from chitosan-based films.

Physical Properties and Release Profiles of Chitosan Mixture Films Containing Salicin, Glycerin and Hyaluronic Acid

“…This behavior can be explained by the formation of a hydrogel, resulting from water absorption and the dissolution of the chitosan matrix (in the form of chitosan lactate) in the PBS solution during the release study of SAL from CS films. Additionally, these observations are in line with our previous research on CS films containing rutin [31]. As outlined in our previous report, the mechanical properties of the CS/GLY/HA films indicate that they are sufficiently elastic to be used as cosmetic beauty masks.…”

“…The establishment of hydrogen bonds between different molecules may compete with the formation of bonds among molecules of the same type. It is worth noting that the CS films also included GLY are used to produce flexible films suitable for cosmetic purposes and to enhance skin moisturization following topical applications [31,39].…”

“…Furthermore, salicin has shown promise in terms of its potential anti-aging effects when applied topically to the skin. Reports suggest that the topical application of salicin can help minimize visible signs of skin aging [29][30][31].…”

“…HA, well known as a natural moisturizing factor, is a natural glycosaminoglycan that participates in cell proliferation, cell migration, and angiogenesis, and it plays an important regulatory role in wound healing [21]. Our previous reports showed that a small addition of HA to CS films improves the performance and physicochemical properties of the prepared films [31,35]. Furthermore, lactic acid is utilized in the formulation of liquid products.…”

ULK1 Mediated Autophagy-Promoting Effects of Rutin-Loaded Chitosan Nanoparticles Contribute to the Activation of NF-κB Signaling Besides Inhibiting EMT in Hep3B Hepatoma Cells

“…They have been tested for their anticancer potential against breast and pancreatic cancer, 41 , 42 management of cerebral ischemia 43 with anti-inflammatory, 44 antibacterial, antioxidant, and photocatalytic activities 45 and had been suggested for possible use in cosmetics and wound healing. 46 , 47 …”