Chitosan-based hydrogels: From preparation to applications, a review

Hong, Fandi; Qiu, Peng; Wang, Yufan; Ren, Peirou; Liu, Jiaxin; Zhao, Jun; Gou, Dongxia

doi:10.1016/j.fochx.2023.101095

Cited by 24 publications

(4 citation statements)

References 117 publications

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“…In addition to biodegradability and biocompatibility, chitosan-based hydrogels are characterized by mechanical strength and elasticity, which may be adjusted by the cross-linking process and the addition of various photo-sensitive components [49]. The latter allows it to absorb contaminants, which is valuable in water purification [101].…”

Section: Photo-sensitive Hydrogelsmentioning

confidence: 99%

Biomedical Trends in Stimuli-Responsive Hydrogels with Emphasis on Chitosan-Based Formulations

Kruczkowska,

Gałęziewska,

Grabowska

et al. 2024

Gels

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Biomedicine is constantly evolving to ensure a significant and positive impact on healthcare, which has resulted in innovative and distinct requisites such as hydrogels. Chitosan-based formulations stand out for their versatile utilization in drug encapsulation, transport, and controlled release, which is complemented by their biocompatibility, biodegradability, and non-immunogenic nature. Stimuli-responsive hydrogels, also known as smart hydrogels, have strictly regulated release patterns since they respond and adapt based on various external stimuli. Moreover, they can imitate the intrinsic tissues’ mechanical, biological, and physicochemical properties. These characteristics allow stimuli-responsive hydrogels to provide cutting-edge, effective, and safe treatment. Constant progress in the field necessitates an up-to-date summary of current trends and breakthroughs in the biomedical application of stimuli-responsive chitosan-based hydrogels, which was the aim of this review. General data about hydrogels sensitive to ions, pH, redox potential, light, electric field, temperature, and magnetic field are recapitulated. Additionally, formulations responsive to multiple stimuli are mentioned. Focusing on chitosan-based smart hydrogels, their multifaceted utilization was thoroughly described. The vast application spectrum encompasses neurological disorders, tumors, wound healing, and dermal infections. Available data on smart chitosan hydrogels strongly support the idea that current approaches and developing novel solutions are worth improving. The present paper constitutes a valuable resource for researchers and practitioners in the currently evolving field.

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Section: Photo-sensitive Hydrogelsmentioning

confidence: 99%

Biomedical Trends in Stimuli-Responsive Hydrogels with Emphasis on Chitosan-Based Formulations

Kruczkowska,

Gałęziewska,

Grabowska

et al. 2024

Gels

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“…This process endows the biopolymers with an enhanced ability to generate and transfer electrical charges, significantly boosting their triboelectric performance (Figure 13d). Crosslinking strengthens the mechanical properties and stability of chitin and chitosan [141,142]. By forming crosslinks between polymer chains, these materials gain durability, making them more suitable for the physical demands of TENG applications [135].…”

Section: Chitin/chitosan-based Triboelectric Devicesmentioning

confidence: 99%

Advanced Triboelectric Applications of Biomass-Derived Materials: A Comprehensive Review

Park,

Kim

2024

Materials

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The utilization of triboelectric materials has gained considerable attention in recent years, offering a sustainable approach to energy harvesting and sensing technologies. Biomass-derived materials, owing to their abundance, renewability, and biocompatibility, offer promising avenues for enhancing the performance and versatility of triboelectric devices. This paper explores the synthesis and characterization of biomass-derived materials, their integration into triboelectric nanogenerators (TENGs), and their applications in energy harvesting, self-powered sensors, and environmental monitoring. This review presents an overview of the emerging field of advanced triboelectric applications that utilize the unique properties of biomass-derived materials. Additionally, it addresses the challenges and opportunities in employing biomass-derived materials for triboelectric applications, emphasizing the potential for sustainable and eco-friendly energy solutions.

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“…On the one hand, chitosan (CH) is a natural polymer derived from the deacetylation of chitin, which is present in the exoskeletons of crustaceans. Chitosan and its derivatives have become promising biological materials due to their distinctive molecular structure, excellent biological activities, and their properties such as biocompatibility, biodegradability, cytocompatibility, non-allergenicity, non-toxicity, and mucoadhesiveness, as well as their antitumor, antioxidant, antibacterial, and antifungal activities [22][23][24][25][26][27]. The reactive functional groups found in chitosan play an important role in aiding the synthesis of three-dimensional hydrogel.…”

Section: Introductionmentioning

confidence: 99%

“…Chitosan-based hydrogels have been widely used in medical and pharmaceutical fields for years. One of their advantages is their complex network architecture, which offers a versatile platform that allows the incorporation of various bioactive compounds [23]. Additionally, chitosan has the capability to improve the bioavailability and stability of multiple small molecule drugs, peptides, and proteins, as well as sustain drug release due to its mucoadhesive properties.…”

Section: Introductionmentioning

confidence: 99%

Chitosan–Type-A-Gelatin Hydrogels Used as Potential Platforms in Tissue Engineering for Drug Delivery

Mehdi-Sefiani,

Granados-Carrera,

Romero

et al. 2024

Gels

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Hydrogels are materials made of crosslinked 3D networks of hydrophilic polymer chains that can absorb and retain significant amounts of water due to their hydrophilic structure without being dissolved. In relation to alternative biomaterials, hydrogels offer increased biocompatibility and biodegradability, giving them distinct advantages. Thus, hydrogel platforms are considered to have the potential for the development of biomedical applications. In this study, the main objective was the development of hybrid hydrogels to act as a drug delivery platform. These hydrogels were made from chitosan (CH) and type A gelatin (G), two natural polymers that provide a supportive environment for cellular attachment, viability, and growth, thanks to their unique properties. Particularly, the use of gelatins for drug delivery systems provides biodegradability, biocompatibility, and non-toxicity, which are excellent properties to be used in the human body. However, gelatins have some limitations, such as thermal instability and poor mechanical properties. In order to improve those properties, the aim of this work was the development and characterization of hybrid hydrogels with different ratios of CH–G (100–0, 75–25, 50–50, 25–75, 0–100). Hydrogels were characterized through multiple techniques, including Fourier transform infrared (FTIR) spectroscopy, rheological and microstructural studies, among others. Moreover, a model hydrophilic drug molecule (tetracycline) was incorporated to evaluate the feasibility of this platform to sustain the release of hydrophilic drugs, by being tested in a solution of Phosphate Buffer Solution at a pH of 7.2 and at 37 °C. The results revealed that the synergy between chitosan and type A gelatin improved the mechanical properties as well as the thermal stability of it, revealing that the best ratios of the biopolymers are 50–50 CH–G and 75–25 CH–G. Thereby, these systems were evaluated in a controlled release of tetracycline, showing a controlled drug delivery of 6 h and highlighting their promising application as a platform for controlled drug release.

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Chitosan-based hydrogels: From preparation to applications, a review

Cited by 24 publications

References 117 publications

Biomedical Trends in Stimuli-Responsive Hydrogels with Emphasis on Chitosan-Based Formulations

Biomedical Trends in Stimuli-Responsive Hydrogels with Emphasis on Chitosan-Based Formulations

Advanced Triboelectric Applications of Biomass-Derived Materials: A Comprehensive Review

Chitosan–Type-A-Gelatin Hydrogels Used as Potential Platforms in Tissue Engineering for Drug Delivery

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