Chitosan‐based hydrogels: recent design concepts to tailor properties and functions

Racine, Lisa; Texier, Isabelle; Auzély‐Velty, Rachel

doi:10.1002/pi.5331

Cited by 96 publications

(52 citation statements)

References 151 publications

(318 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chitin exists in marine media and especially in the exoskeleton of crustaceans, or cartilages of mollusks, cuticles of insects and cell walls of micro‐organisms. Chitosan can be easily characterized as a promising material not only because of its physical properties (macromolecular structure, non‐toxicity, biocompatibility, biodegradability, low cost etc. ) and applications in many fields (biotechnology, medicine, membranes, cosmetics, food industry etc.…”

Section: Introductionmentioning

confidence: 99%

Chitosan adsorbents for dye removal: a review

2017

View full text Add to dashboard Cite

One of the most important decontamination techniques is considered to be adsorption. It is fast, simple, low cost with many opportunities to modify the initial materials after appropriate synthesis routes etc. Numerous adsorbent materials have been prepared in the last few years having as the ultimate scope to remove some pollutants especially from contaminated waters (effluents originating from industry). But the composition of each type of effluent varies. Dyes are some major components of industrial wastewaters. Chitosan (poly--(1 → 4)-2-amino-2-deoxy-D-glucose) is a nitrogenous (amino-based) polysaccharide which is produced in large quantities by N-deacetylation of (its source compound) chitin. The major advantage of chitosan is the existence of modifiable positions in its chemical structure. Modification of the chitosan molecule by (i) grafting (inserting functional groups) or (ii) crosslinking reactions (uniting the macromolecular chains with each other) leads to the formation of chitosan derivatives with superior properties (enhancement of adsorption capacity and resistance in extreme medium conditions, respectively). This review summarizes the important contribution of chitosan derivatives to the dye removal process by adsorption.

show abstract

Section: Introductionmentioning

confidence: 99%

Chitosan adsorbents for dye removal: a review

2017

View full text Add to dashboard Cite

show abstract

“…Boiling chitin in potassium hydroxide results in chitosan. Chitin is also biodegradable and does not cause a strong response from the immune system [78]. It has huge applications from medicine and biomaterials [61].…”

Section: Natural Polymersmentioning

confidence: 99%

Polymer- and Hybrid-Based Biomaterials for Interstitial, Connective, Vascular, Nerve, Visceral and Musculoskeletal Tissue Engineering

2020

View full text Add to dashboard Cite

In this review, materials based on polymers and hybrids possessing both organic and inorganic contents for repairing or facilitating cell growth in tissue engineering are discussed. Pure polymer based biomaterials are predominantly used to target soft tissues. Stipulated by possibilities of tuning the composition and concentration of their inorganic content, hybrid materials allow to mimic properties of various types of harder tissues. That leads to the concept of "one-matches-all" referring to materials possessing the same polymeric base, but different inorganic content to enable tissue growth and repair, proliferation of cells, and the formation of the ECM (extra cellular matrix). Furthermore, adding drug delivery carriers to coatings and scaffolds designed with such materials brings additional functionality by encapsulating active molecules, antibacterial agents, and growth factors. We discuss here materials and methods of their assembly from a general perspective together with their applications in various tissue engineering sub-areas: interstitial, connective, vascular, nervous, visceral and musculoskeletal tissues. The overall aims of this review are two-fold: (a) to describe the needs and opportunities in the field of bio-medicine, which should be useful for material scientists, and (b) to present capabilities and resources available in the area of materials, which should be of interest for biologists and medical doctors.Polymers 2020, 12, 620 2 of 30 allows to tailor functionalize the coatings, where their responsiveness to external stimuli is one of their biggest advantages.Polymers stand out as a special class of materials due to the flexibility of design of their blocks and various functionalities, which is brought by their versatile assembly or by introducing additional side-groups or blocks, in the case of block-co-polymers. In this regard, both synthetic and biocompatible polymers are available, and polymer engineering represents a growing area tailoring the needs often driven by applications. With all advantages and the flexibility of the design, there is one significant weakness of polymers-the softness. In regard with tissue engineering, that translates to the fact that some materials can match predominantly soft tissue, but it is difficult to tune mechanical properties of polymers to match the hardness of bones, tendons, etc. And since mechanical properties of materials affect and even drive cell and tissue growth, enhancement of mechanical properties of polymers and biomaterials is essential. Chemical crosslinking can be applied to address these challenges, but that solves problems only partially.To solve these challenges the so-called hybrid materials [6] are used, which possess both inorganic and organic contents. Increasingly, hybrid materials are used in designing the extracellular matrix. The hybrid matrix design for various tissue engineering applications should meet bio-medical requirements. On the one hand, it needs to be biocompatible and biodegradable, which is achieved through the po...

show abstract

“…It shows that alkylated chitosan is soluble in a pH range of 3 to 14, in comparison to the chitosan without alkylation that is soluble at very low pH values from 3 to 4.5. This is due to the protonation of the amino groups [36][37][38][39] [see Figure 3(b)]. Figure 4 shows the FTIR spectra of the synthesized copolymers.…”

Section: Synthesis Of N-alkylated Chitosanmentioning

confidence: 99%

Hydrogels based on alkylated chitosan and polyelectrolyte copolymers

Palacio

Urbano

Rivas

2018

J of Applied Polymer Sci

View full text Add to dashboard Cite

Hydrogels formed by alkylated chitosan with N‐(3‐chloro‐2‐hydroxypropyl) trimethylammonium chloride and synthetic copolymers forming polyelectrolyte complexes are presented. The copolymer polyelectrolytes were synthesized through free‐radical polymerization. Their compositions and reactivity parameters were determined by the Finemann–Ross and Kelen–Tüdos methods. The copolymers have structures that tend to be alternating. The hydrogels were characterized by thermogravimetric analysis, Fourier transform infrared spectroscopy, proton nuclear magnetic resonance, scanning electron microscopy, and water solubility tests at different pH values. For the formation of the hydrogels, they were prepared using different molar ratios of alkylated chitosan and polyelectrolyte copolymers. Their stability was determined by rheological analysis, evaluating the response as a function of strain and frequency. The rheological tests showed that the stability of the polyelectrolyte complexes followed the trend ChT‐CP2 > ChT‐CP3 > ChT‐CP1 due to the presence of greater electrostatic interactions. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46556.

show abstract

Chitosan‐based hydrogels: recent design concepts to tailor properties and functions

Cited by 96 publications

References 151 publications

Chitosan adsorbents for dye removal: a review

Chitosan adsorbents for dye removal: a review

Polymer- and Hybrid-Based Biomaterials for Interstitial, Connective, Vascular, Nerve, Visceral and Musculoskeletal Tissue Engineering

Hydrogels based on alkylated chitosan and polyelectrolyte copolymers

Contact Info

Product

Resources

About