Chitosan-based intelligent polymeric networks for site-specific colon medication delivery: A comprehensive study on controlled release of diloxanide furoate and network formation dynamics

Mahmood, Ayesha; Mahmood, Asif; Sarfraz, Rai Muhammad; Hussain, Zahid; Afzal, Atika; Boublia, Abir; Bhutto, Javed Khan; Alreshidi, Maha Awjan; Yadav, Krishna Kumar; Elboughdiri, Noureddine; Benguerba, Yacine

doi:10.1016/j.ijbiomac.2023.128089

Cited by 17 publications

(9 citation statements)

References 40 publications

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“…Moreover, electrostatic repulsion forces between the polymeric nexus and ionized carboxylic acid pendant groups aid in the swelling of the polymeric network. Mahmood et al 2023 developed an intelligent carrier system for site specific delivery of diloxanide furoate and they have reported similar facts with respect to ionization of carboxylic groups leading to swelling of the polymeric network …”

Section: Resultsmentioning

confidence: 95%

“…Mahmood et al 2023 developed an intelligent carrier system for site specific delivery of diloxanide furoate and they have reported similar facts with respect to ionization of carboxylic groups leading to swelling of the polymeric network. 37 …”

Section: Resultsmentioning

confidence: 99%

“…To confirm the biocompatibility of the newly developed nanogel system, an acute oral toxicological evaluation was conducted using various histopathological, biochemical, and hematological markers. 37 The testing was carried out in accordance with the Organization for Economic Cooperation and Development (OECD) criteria for chemical toxicity research. The study showed that none of the subjects exhibited any signs of morbidity and their eyes, oral cavity, hair, and skin were all in normal conditions.…”

Section: Resultsmentioning

confidence: 99%

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Preparation, In Vitro Characterization, and Evaluation of Polymeric pH-Responsive Hydrogels for Controlled Drug Release

Mahmood,

Sarfraz,

Mahmood

et al. 2024

ACS Omega

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The purpose of the current research is to formulate a smart drug delivery system for solubility enhancement and sustained release of hydrophobic drugs. Drug solubility-related challenges constitute a significant concern for formulation scientists. To address this issue, a recent study focused on developing PEG-g-poly(MAA) copolymeric nanogels to enhance the solubility of olmesartan, a poorly soluble drug. The researchers employed a free radical polymerization technique to formulate these nanogels. Nine formulations were formulated. The newly formulated nanogels underwent comprehensive tests, including physicochemical assessments, dissolution studies, solubility evaluations, toxicity investigations, and stability examinations. Fourier transform infrared (FTIR) investigations confirmed the successful encapsulation of olmesartan within the nanogels, while thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) studies verified their thermal stability. Scanning electron microscopy (SEM) images revealed the presence of pores on the surface of the nanogels, facilitating water penetration and promoting rapid drug release. Moreover, powder X-ray diffraction (PXRD) studies indicated that the prepared nanogels exhibited an amorphous structure. The nanogel carrier system led to a significant enhancement in olmesartan's solubility, achieving a remarkable 12.3-fold increase at pH 1.2 and 13.29-fold rise in phosphate buffer of pH 6.8 (NGP3). Significant swelling was observed at pH 6.8 compared to pH 1.2. Moreover, the formulated nexus is nontoxic and biocompatible and depicts considerable potential for delivery of drugs and protein as well as heat-sensitive active moieties.

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Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Preparation, In Vitro Characterization, and Evaluation of Polymeric pH-Responsive Hydrogels for Controlled Drug Release

Mahmood,

Sarfraz,

Mahmood

et al. 2024

ACS Omega

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“…Due to their non-cytotoxic nature, excellent biocompatibility, and remarkable drug incorporation ability, SCHMs have found extensive potential applications in diverse fields including tissue engineering, cell culture, and therapeutic drug delivery, especially prospective in intelligent drug delivery systems to address the needs of diseased tissues and organs. [11][12][13][14][15][16][17] The materials have garnered significant attention in recent years. [18][19][20][21][22] Electricity was a clean, stable, and manageable external stimulus among all sources of external stimuli.…”

Section: Introductionmentioning

confidence: 99%

“…SCHMs were widely used in the preparation of sensors, actuators, drug delivery systems, and artificial muscles. Due to their non‐cytotoxic nature, excellent biocompatibility, and remarkable drug incorporation ability, SCHMs have found extensive potential applications in diverse fields including tissue engineering, cell culture, and therapeutic drug delivery, especially prospective in intelligent drug delivery systems to address the needs of diseased tissues and organs 11–17 . The materials have garnered significant attention in recent years 18–22 …”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of poly(N‐isopropylacrylamide‐co‐iron(5‐acrylamido‐1,10‐phenanthroline)) based electro‐responsive hydrogel

Zhang,

Ma,

Mao

et al. 2024

Journal of Polymer Science

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Poly(N‐isopropylacrylamide‐co‐iron(5‐acrylamido‐1,10‐phenanthroline)) based electro‐responsive hydrogel is prepared by the radical polymerization of N‐isopropylacrylamide (NIPAAm), iron (5‐acrylamido‐1,10‐phenanthroline) and bis (1,10‐phenanthroline) (ferroin monomer), using 2,2‐azobisisobutyronitrile (AIBN) as initiator and N,N′‐methylenebisacrylamide (BIS) as cross‐linker. The structure of the hydrogel is characterized by Fourier transform infrared spectroscopy (FTIR). The impact of different contents of ferroin and cross‐linker on swelling properties, crosslinking degree, mechanical properties, and deformation properties of hydrogels are investigated, which indicates that the hydrogels containing ferroin are low voltage responsive. The hydrogel exhibits a deformation rate of 71.56% and a deformation speed of 2%/s at a voltage of 10 V when the ferroin content is 2.67%. The deformation rate and deformation speed of hydrogels increase with increasing voltage. Therefore, the deformation rate can reach 80.69%, and the deformation speed can reach 15.56%/s. The crosslinking degree increases with increasing BIS content in hydrogels, while leading to a reduction in swelling degree and swelling rate. Moreover, the elongation at break decreases first and then increases, the tensile strength and compressive strength increase. Furthermore, the minimum responsive voltage of hydrogels for deformation decreases, the deformation rate and deformation speed increase first and then decrease.

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Green synthesis of bimetallic Se@TiO2NPs and their formulation into biopolymers and their utilization as antimicrobial, anti-diabetic, antioxidant, and healing agent in vitro

Alghonaim,

Alsalamah,

Mohammad

et al. 2024

Biomass Conv. Bioref.

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Chitosan-based intelligent polymeric networks for site-specific colon medication delivery: A comprehensive study on controlled release of diloxanide furoate and network formation dynamics

Cited by 17 publications

References 40 publications

Preparation, In Vitro Characterization, and Evaluation of Polymeric pH-Responsive Hydrogels for Controlled Drug Release

Preparation, In Vitro Characterization, and Evaluation of Polymeric pH-Responsive Hydrogels for Controlled Drug Release

Preparation and characterization of poly(N‐isopropylacrylamide‐co‐iron(5‐acrylamido‐1,10‐phenanthroline)) based electro‐responsive hydrogel

Green synthesis of bimetallic Se@TiO2NPs and their formulation into biopolymers and their utilization as antimicrobial, anti-diabetic, antioxidant, and healing agent in vitro

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