Chitosan-Based Scaffold for Mineralized Tissues Regeneration

Sukpaita, Teerawat; Chirachanchai, Suwabun; Pimkhaokham, Atiphan; Ampornaramveth, Ruchanee Salingcarnboriboon

doi:10.3390/md19100551

Cited by 73 publications

(55 citation statements)

References 72 publications

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“…It has the ability to stimulate the recruitment and adhesion of osteogenic progenitor cells, facilitating bone formation. In addition, it has been shown that no inflammatory or allergic reactions occur after topical application ( Kim et al, 2003 ; Waibel et al, 2011 ; Azuma et al, 2015 ; Sukpaita et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Bone Quantification Around Chitosan-Coated Titanium Dental Implants: A Preliminary Study by Micro-CT Analysis in Jaw of a Canine Model

López-Valverde

Cortés

et al. 2022

Front. Bioeng. Biotechnol.

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Surface treatments of Ti in the dental implant industry are performed with the aim of in-creasing its bioactivity and osseointegration capacity. Chitosan (Cht) is a polysaccharide that has been proposed as a promising biomaterial in tissue engineering and bone regeneration, due to its ability to stimulate the recruitment and adhesion of osteogenic progenitor cells. The aim of our preliminary study was to evaluate, by micro-computed tomography (micro-CT), the osseointegration and bone formation around Cht-coated implants and to compare them with conventional surface-etched implants (SLA type). Four im-plants (8.5 mm length × 3.5 mm Ø) per hemiarch, were inserted into the jaws of five dogs, divided into two groups: chitosan-coated implant group (ChtG) and control group (CG). Twelve weeks after surgery, euthanasia was performed, and sectioned bone blocks were obtained and scanned by micro-CT and two bone parameters were measured: bone in contact with the implant surface (BCIS) and peri-implant bone area (PIBA). For BCIS and PIBA statistically significant values were obtained for the ChtG group with respect to CG (p = 0.005; p = 0.014 and p < 0.001 and p = 0.002, respectively). The results, despite the limitations, demonstrated the usefulness of chitosan coatings. However, studies with larger sample sizes and adequate experimental models would be necessary to confirm the results.

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Section: Discussionmentioning

confidence: 99%

Bone Quantification Around Chitosan-Coated Titanium Dental Implants: A Preliminary Study by Micro-CT Analysis in Jaw of a Canine Model

López-Valverde

Cortés

et al. 2022

Front. Bioeng. Biotechnol.

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“…Chitosan has been formulated in different systems for bone tissue engineering, including scaffolds, sponges, hydrogels, micro-nanospheres, and membranes, among others [98,102]. According to Sukpaita et al, 3D biomaterial scaffolds are one of the three main pillars of bone tissue engineering, along with osteogenic stem cells and bioactive molecules such as growth factors or drugs.…”

Section: Bone Regenerationmentioning

confidence: 99%

Applications of Chitosan in Surgical and Post-Surgical Materials

et al. 2022

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The continuous advances in surgical procedures require continuous research regarding materials with surgical applications. Biopolymers are widely studied since they usually provide a biocompatible, biodegradable, and non-toxic material. Among them, chitosan is a promising material for the development of formulations and devices with surgical applications due to its intrinsic bacteriostatic, fungistatic, hemostatic, and analgesic properties. A wide range of products has been manufactured with this polymer, including scaffolds, sponges, hydrogels, meshes, membranes, sutures, fibers, and nanoparticles. The growing interest of researchers in the use of chitosan-based materials for tissue regeneration is obvious due to extensive research in the application of chitosan for the regeneration of bone, nervous tissue, cartilage, and soft tissues. Chitosan can serve as a substance for the administration of cell-growth promoters, as well as a support for cellular growth. Another interesting application of chitosan is hemostasis control, with remarkable results in studies comparing the use of chitosan-based dressings with traditional cotton gauzes. In addition, chitosan-based or chitosan-coated surgical materials provide the formulation with antimicrobial activity that has been highly appreciated not only in dressings but also for surgical sutures or meshes.

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“…Synthetic polymers such as polylactic acid (PLA) [4], polyvinyl alcohol (PVA) [5], poly (lactic-co-glycolic) (PLGA) [6], and poly ε-caprolactone (PCL) [7] have been used for the preparation of 3D scaffolds due to their easily adjustable porosity, mechanical performance, and degradation time. With their higher biocompatibility, natural polymers such as gelatin [8], collagen [9], chitosan [10], alginate [11], elastin [12], and fibrin [13] have attracted researchers' attention for the preparation of 3D scaffolds that faithfully replicate the native tissue vasculature and channel interconnections that allow the perfusion of nutrients and oxygen diffusion during regeneration. Moreover, the degradation kinetics can be coordinated with the regenerative effects in order to drive the reformation of scarless tissue, reducing the necessity for secondary surgical procedures to eradicate any degenerated scaffold [14].…”

Section: Introductionmentioning

confidence: 99%

Graphene Oxide–Protein-Based Scaffolds for Tissue Engineering: Recent Advances and Applications

et al. 2022

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The field of tissue engineering is constantly evolving as it aims to develop bioengineered and functional tissues and organs for repair or replacement. Due to their large surface area and ability to interact with proteins and peptides, graphene oxides offer valuable physiochemical and biological features for biomedical applications and have been successfully employed for optimizing scaffold architectures for a wide range of organs, from the skin to cardiac tissue. This review critically focuses on opportunities to employ protein–graphene oxide structures either as nanocomposites or as biocomplexes and highlights the effects of carbonaceous nanostructures on protein conformation and structural stability for applications in tissue engineering and regenerative medicine. Herein, recent applications and the biological activity of nanocomposite bioconjugates are analyzed with respect to cell viability and proliferation, along with the ability of these constructs to sustain the formation of new and functional tissue. Novel strategies and approaches based on stem cell therapy, as well as the involvement of the extracellular matrix in the design of smart nanoplatforms, are discussed.

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Chitosan-Based Scaffold for Mineralized Tissues Regeneration

Cited by 73 publications

References 72 publications

Bone Quantification Around Chitosan-Coated Titanium Dental Implants: A Preliminary Study by Micro-CT Analysis in Jaw of a Canine Model

Bone Quantification Around Chitosan-Coated Titanium Dental Implants: A Preliminary Study by Micro-CT Analysis in Jaw of a Canine Model

Applications of Chitosan in Surgical and Post-Surgical Materials

Graphene Oxide–Protein-Based Scaffolds for Tissue Engineering: Recent Advances and Applications

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