Chitosan-Based Scaffolds for Facilitated Endogenous Bone Re-Generation

Zhao, Yao; Zhao, Sinuo; Ma, Zhengxin; Ding, Chunmei; Chen, Jingdi; Li, Jianshu

doi:10.3390/ph15081023

Cited by 19 publications

(9 citation statements)

References 195 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CS, as a cationic polysaccharide, has good biocompatibility, biodegradability and antibacterial properties ( Zhao et al, 2022b ). CS promotes osteogenic differentiation by upregulating the expression levels of Osterix and bone sialoprotein (BSP).…”

Section: Modification Of Bp Nanoparticles For Os Therapymentioning

confidence: 99%

Black phosphorus, an advanced versatile nanoparticles of antitumor, antibacterial and bone regeneration for OS therapy

Sun,

Han,

Zhao

et al. 2024

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

Osteosarcoma (OS) is the most common primary malignant bone tumor. In the clinic, usual strategies for OS treatment include surgery, chemotherapy, and radiation. However, all of these therapies have complications that cannot be ignored. Therefore, the search for better OS treatments is urgent. Black phosphorus (BP), a rising star of 2D inorganic nanoparticles, has shown excellent results in OS therapy due to its outstanding photothermal, photodynamic, biodegradable and biocompatible properties. This review aims to present current advances in the use of BP nanoparticles in OS therapy, including the synthesis of BP nanoparticles, properties of BP nanoparticles, types of BP nanoparticles, and modification strategies for BP nanoparticles. In addition, we have discussed comprehensively the application of BP in OS therapy, including single, dual, and multimodal synergistic OS therapies, as well as studies about bone regeneration and antibacterial properties. Finally, we have summarized the conclusions, limitations and perspectives of BP nanoparticles for OS therapy.

show abstract

Section: Modification Of Bp Nanoparticles For Os Therapymentioning

confidence: 99%

Black phosphorus, an advanced versatile nanoparticles of antitumor, antibacterial and bone regeneration for OS therapy

Sun,

Han,

Zhao

et al. 2024

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Dried chitosan scaffolds are generally combined with other natural or synthetic polymers since in its pure form, they have low bioactivity and mechanical stability. Such composite chitosan scaffolds have been shown to efficiently promote endogenous bone repair [ 34 ]. The dried scaffolds can be fabricated by freezing and lyophilization, salt leaching, and electrospinning [ 26 ].…”

Section: Bone Cartilage and Dental Tissuesmentioning

confidence: 99%

Chitosan-Based Biomaterials for Tissue Regeneration

et al. 2023

View full text Add to dashboard Cite

Chitosan is a chitin-derived biopolymer that has shown great potential for tissue regeneration and controlled drug delivery. It has numerous qualities that make it attractive for biomedical applications such as biocompatibility, low toxicity, broad-spectrum antimicrobial activity, and many others. Importantly, chitosan can be fabricated into a variety of structures including nanoparticles, scaffolds, hydrogels, and membranes, which can be tailored to deliver a desirable outcome. Composite chitosan-based biomaterials have been demonstrated to stimulate in vivo regeneration and the repair of various tissues and organs, including but not limited to, bone, cartilage, dental, skin, nerve, cardiac, and other tissues. Specifically, de novo tissue formation, resident stem cell differentiation, and extracellular matrix reconstruction were observed in multiple preclinical models of different tissue injuries upon treatment with chitosan-based formulations. Moreover, chitosan structures have been proven to be efficient carriers for medications, genes, and bioactive compounds since they can maintain the sustained release of these therapeutics. In this review, we discuss the most recently published applications of chitosan-based biomaterials for different tissue and organ regeneration as well as the delivery of various therapeutics.

show abstract

“…the addition of CaP into a chitosan polymer matrix improved the biodegradability, osteoconductivity, and mechanical strength of the composite [75,76]. Thus, it represents an ideal approach to improve the performance of these composite scaffolds [77][78][79][80]. Many research works can be found in the scientific literature regarding the preparation and development of chitosan-HAp composites, and have consistently proven the beneficial effect of chitosan on the enhancement of the properties of CaP nanoparticles [81,82].…”

Section: Chitosan-based Bioceramic Compositesmentioning

confidence: 99%

Calcium Phosphate Loaded Biopolymer Composites—A Comprehensive Review on the Most Recent Progress and Promising Trends

Furkó

Balázsi

2023

Coatings

View full text Add to dashboard Cite

Biocompatible ceramics are extremely important in bioengineering, and very useful in many biomedical or orthopedic applications because of their positive interactions with human tissues. There have been enormous efforts to develop bioceramic particles that cost-effectively meet high standards of quality. Among the numerous bioceramics, calcium phosphates are the most suitable since the main inorganic compound in human bones is hydroxyapatite, a specific phase of the calcium phosphates (CaPs). The CaPs can be applied as bone substitutes, types of cement, drug carriers, implants, or coatings. In addition, bioresorbable bioceramics have great potential in tissue engineering in their use as a scaffold that can advance the healing process of bones during the normal tissue repair process. On the other hand, the main disadvantages of bioceramics are their brittleness and poor mechanical properties. The newest advancement in CaPs doping with active biomolecules such as Mg, Zn, Sr, and others. Another set of similarly important materials in bioengineering are biopolymers. These include natural polymers such as collagen, cellulose acetate, gelatin, chitosan, and synthetic polymers, for example, polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA), and polycaprolactone (PCL). Various types of polymer have unique properties that make them useful in different fields. The combination of CaP particles with different biopolymers gives rise to new opportunities for application, since their properties can be changed and adjusted to the given requirements. This review offers an insight into the most up-to-date advancements in the preparation and evaluation of different calcium phosphate–biopolymer composites, highlighting their application possibilities, which largely depend on the chemical and physical characteristics of CaPs and the applied polymer materials. Overall, these composites can be considered advanced materials in many important biomedical fields, with potential to improve the quality of healthcare and to assist in providing better outcomes as scaffolds in bone healing or in the integration of implants in orthopedic surgeries.

show abstract

Chitosan-Based Scaffolds for Facilitated Endogenous Bone Re-Generation

Cited by 19 publications

References 195 publications

Black phosphorus, an advanced versatile nanoparticles of antitumor, antibacterial and bone regeneration for OS therapy

Black phosphorus, an advanced versatile nanoparticles of antitumor, antibacterial and bone regeneration for OS therapy

Chitosan-Based Biomaterials for Tissue Regeneration

Calcium Phosphate Loaded Biopolymer Composites—A Comprehensive Review on the Most Recent Progress and Promising Trends

Contact Info

Product

Resources

About