Chitosan based sorafenib tosylate loaded magnetic nanoparticles: Formulation and in-vitro characterization

Dahiya, Mandeep; Awasthi, Rajendra; Yadav, Jaya Parkash; Sharma, Shammi; Dua, Kamal; Dureja, Harish

doi:10.1016/j.ijbiomac.2023.124919

Cited by 5 publications

(2 citation statements)

References 71 publications

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“…To study the lattice structure, X-ray diffraction (XRD) study of berberine HCl, diacerein, phosphatidylcholine, sodium deoxycholate, and drug-loaded optimized transferosomes (formulation DDT-10) was carried out by a X-ray powder diffractometer (D8 Advance Eco, Bruker, United States) using Cu Kα radiation with a 40 kV voltage, 15.4 nm wavelength, and 200 mA current. Samples were scanned within the 2 θ range of 0-90° at a step size of 0.02° [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

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Berberine HCl and diacerein loaded dual delivery transferosomes: Formulation and optimization using Box-Behnken design

Singh,

Awasthi

2024

ADMET DMPK

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Introduction: Berberine is a poorly water-soluble alkaloid compound showing significant anti-inflammatory characteristics. It reduces the levels of pro-inflammatory and inflammatory cytokines, including tumour necrosis factor (TNF-????, IFN-????) and interleukin (IL-23, IL-12, and IL-23). Diacerein significantly reduces the splenomegaly associated with psoriasis. It downregulates the production of TNF-α and IL-12. Method: This study reported the development of transferosomes containing berberine HCl and diacerein using a film hydration method followed by optimization using a Box-Behnken design. Sodium deoxycholate was used as an edge activator. The impact of independent variables (amount of phosphatidylcholine, amount of edge activator, and sonication cycles) on dependent variables (particle size and entrapment efficiency) was examined. The optimized formulation was characterized for polydispersity index, vesicle size, entrapment efficiency, ζ potential, spectral analysis like Fourier transform infrared, thermal analysis, X-ray diffraction, deformability, transmission electron microscopy, antioxidant assay, in-vitro release, and ex-vivo skin permeation studies. Results: The optimized formulation had a particle size of 110.90±2.8 nm with high entrapment efficiency (89.50±1.5 of berberine HCl and 91.23±1.8 of diacerein). Deformability, polydispersity index, ζ potential, and antioxidant activity of the optimized formulation were 2.44, 0.296, -13.3, and 38.36 %, respectively. Optimized transferosomes exhibited 82.093±0.81 % and 85.02±3.81 % release of berberine HCl and diacerein after 24 h of dissolution study. The transdermal flux of optimized formulation was 0.0224 µg cm-2 h-1 (2.24 cm h-1 permeation coefficient) and 0.0462 µg cm-2 h-1 (4.62 cm h-1 permeation coefficient), respectively, for berberine HCl and diacerein. Raman analysis of treated pig skin confirmed that the transferosomes can permeate the skin. No change in the skin condition or irritation was observed in BALB/c mice. Formulation stored at 4 and 25±2 °C / 60±5 % relative humidity was stable for 3 months. Conclusions: Thus, the results demonstrated successful optimization of the transferosomes for the efficient topical delivery of berberine HCl and diacerein in the effective management of psoriasis.

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Section: Methodsmentioning

confidence: 99%

“…For AFM analysis, a thin film was obtained by placing a drop of dispersion on a thin glass slide using a spin coater. Images were captured at 300 kHz cantilever frequency, 256×256-pixel resolution, and a nominal force constant of 48 N m -1 at room temperature [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

Berberine HCl and diacerein loaded dual delivery transferosomes: Formulation and optimization using Box-Behnken design

Singh,

Awasthi

2024

ADMET DMPK

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MXene-encapsulated ZIF-8@Liposomes for NIR-enhanced photothermal therapy in hepatocellular carcinoma treatment: In vitro, in vivo, and in silico study

Elbeltagi,

Madkhali,

Alharbi

et al. 2025

Archives of Biochemistry and Biophysics

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Enhanced functionalization of superparamagnetic Fe3O4 nanoparticles for advanced drug enrichment and separation applications

Shen,

Wang,

Tian

et al. 2024

BMC Chemistry

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Background superparamagnetic ferroferric oxide (Fe 3 O 4 ) nanoparticles can be extensively functionalized for applications in drug enrichment and separation. Their high magnetic responsiveness and controllable surface modification enable rapid drug enrichment and separation under external magnetic fields. This study aimed to enhance the application potential of superparamagnetic Fe 3 O 4 nanoparticles in the field of drug enrichment and separation by functionalizing these nanoparticles to improve their biocompatibility and targeting capabilities. Methods superparamagnetic Fe 3 O 4 nanoparticles functionalized with dopamine were synthesized using benzyl alcohol as the solvent and iron acetylacetonate as the precursor. The dopamine-functionalized superparamagnetic iron oxide nanoparticles were used to analyze protein enrichment and separation. Characterization of the nanoparticles was conducted, including analysis of particle size distribution, Zeta potential, and fluorescence spectra using a fluorescence spectrophotometer. Results the Fe 3 O 4 nanoparticles maintained high magnetism from the original material and exhibited uniform particle size distribution and stable Zeta potential. The saturation magnetization of dopamine-functionalized superparamagnetic Fe 3 O 4 nanoparticles showed no significant difference compared to before coating, indicating minimal influence of dopamine on the internal magnetic core of the nanoparticles. The Fe 3 O 4 nanoparticles demonstrated good biocompatibility and stability. Conclusion functionalization of superparamagnetic Fe 3 O 4 nanoparticles significantly enhances their efficiency in drug enrichment and separation processes, suggesting broad applications in the pharmaceutical industry.

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Chitosan based sorafenib tosylate loaded magnetic nanoparticles: Formulation and in-vitro characterization

Cited by 5 publications

References 71 publications

Berberine HCl and diacerein loaded dual delivery transferosomes: Formulation and optimization using Box-Behnken design

Berberine HCl and diacerein loaded dual delivery transferosomes: Formulation and optimization using Box-Behnken design

MXene-encapsulated ZIF-8@Liposomes for NIR-enhanced photothermal therapy in hepatocellular carcinoma treatment: In vitro, in vivo, and in silico study

Enhanced functionalization of superparamagnetic Fe3O4 nanoparticles for advanced drug enrichment and separation applications

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