Chitosan-based topical formulation integrated with green-synthesized silver nanoparticles utilizing Camellia sinensis leaf extracts: A promising approach for managing infected wounds

Ahmad, Mohammad Zaki; Saeed, Abdulhakeem Mohammed; Elnoubi, Osman A.E.; Alasiri, Ali S.; Abdel-Wahab, Basel A.; Alqahtani, Abdulsalam A.; Pathak, Kalyani; Saikia, Riya; Kakoti, Bibhuti Bhusan; Das, Aparoop

doi:10.1016/j.ijbiomac.2023.128573

Cited by 8 publications

(3 citation statements)

References 73 publications

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“…As previously described in other studies, elevated temperatures expedite the reduction of silver ions, thereby enhancing the rate of AgNP formation [29]. However, excessively high temperatures may lead to aggregation, resulting in a decline in the maximum SPR absorbance peak [30]. Furthermore, the maximum absorption peak of AgNPs revealed significant variations, corresponding to the different reaction times.…”

Section: Optimized Green Synthesis Of Dmy-agnpssupporting

confidence: 52%

“…This filtered through a 10 µm filter membrane, and was added to 3 mL of 10 mM AgNO 3 solution. This solution mixture was swayed and heated in an incubation shaker (QYC-2102, Shanghai Cimo Medical Instrument Co., Ltd., Shanghai, China) periodically (30,60,90,120,150,180,210,240, and 270 min). The preparation parameter of AgNPs was optimized using single-factor experimentation, including the molar ratio of DMY to AgNO 3 (4:1, 2:1, 1:1, 1:1.5, and 1:2), the pH (6.0, 7.0, 8.0, 9.0, 10.0, and 11.0), and the reaction temperatures (30,40,50,60, and 70 • C).…”

Section: Optimized Process Of Dmy-agnp Synthesismentioning

confidence: 99%

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Silver Nanoparticles Encapped by Dihydromyricetin: Optimization of Green Synthesis, Characterization, Toxicity, and Anti-MRSA Infection Activities for Zebrafish (Danio rerio)

Qi,

Wang,

Huang

et al. 2024

IJMS

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To achieve the environmentally friendly and rapid green synthesis of efficient and stable AgNPs for drug-resistant bacterial infection, this study optimized the green synthesis process of silver nanoparticles (AgNPs) using Dihydromyricetin (DMY). Then, we assessed the impact of AgNPs on zebrafish embryo development, as well as their therapeutic efficacy on zebrafish infected with Methicillin-resistant Staphylococcus aureus (MRSA). Transmission electron microscopy (TEM) and dynamic light-scattering (DLS) analyses revealed that AgNPs possessed an average size of 23.6 nm, a polymer dispersity index (PDI) of 0.197 ± 0.0196, and a zeta potential of −18.1 ± 1.18 mV. Compared to other published green synthesis products, the optimized DMY-AgNPs exhibited smaller sizes, narrower size distributions, and enhanced stability. Furthermore, the minimum concentration of DMY-AgNPs required to affect zebrafish hatching and survival was determined to be 25.0 μg/mL, indicating the low toxicity of DMY-AgNPs. Following a 5-day feeding regimen with DMY-AgNP-containing food, significant improvements were observed in the recovery of the gills, intestines, and livers in MRSA-infected zebrafish. These results suggested that optimized DMY-AgNPs hold promise for application in aquacultures and offer potential for further clinical use against drug-resistant bacteria.

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Section: Optimized Green Synthesis Of Dmy-agnpssupporting

confidence: 52%

Section: Optimized Process Of Dmy-agnp Synthesismentioning

confidence: 99%

Silver Nanoparticles Encapped by Dihydromyricetin: Optimization of Green Synthesis, Characterization, Toxicity, and Anti-MRSA Infection Activities for Zebrafish (Danio rerio)

Qi,

Wang,

Huang

et al. 2024

IJMS

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“…Ahmad et al that found that temperature is an important factor to obtained silver nanoparticles, the authors observed the formation of AgNPs in 40 °C and 100 °C. In this work all synthesis are made at room temperature [24].…”

Section: Synthesis Optimization and Characterization Of Agnp'smentioning

confidence: 99%

Instant green synthesis: obtaining stable nanoparticles and understanding the extract's behavior in the particle formation mechanism

Franco,

Boscardin,

Terhaag

et al. 2024

Nano Ex.

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Numerous plant extracts are abundant in biomolecules that can be employed in the biogenic synthesis of metallic nanoparticles owing to their potent reducing capabilities. The mechanism by which biomolecules act as reducers and expedite the reduction of silver ions remains poorly understood. This study presents an instantaneous and environmentally friendly synthesis of silver nanoparticles (AgNPs) using varying concentrations of commercially available green tea and concentrations of a dextrose-reducing solution. The AgNPs formed instantaneously, likely due to the competitive reaction between the polyphenols present in green tea and the dextrose. The best AgNPs produced using a diluted green tea solution at a concentration of 0.05 g of tea/mL (showed DPPH 0.013 ±(0.1)μmol TEAC/g, FRAP 10.3±(0.1) μmol TEAC/g and TPC 0.12±(0.001) μgGAE/g) and 100 μL of dextrose solution exhibited high stability over a period of 90 days, as confirmed by UV-Vis spectroscopy and dynamic light scattering. The resulting nanoparticles are extremely small, measuring approximately 30 to 50 nm in size, and exhibit a spherical morphology as evidenced by SEM imaging. The plasmon band of AgNPs is a more prominent and formed band in more diluted tea and higher proportions of dextrose added. Probably, the results of 2nd extraction of green tea diluted that was viewed in the results of DPPH, FRAP, TPC, and HPLC can be evidence that phenolic compounds, mainly, caffeine and gallic acid, are contributing to forming the silver nanoparticles. This fundamental knowledge showed the method employed is ecologically sound and adheres to green principles.

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Green synthesis and characterization of silver nanoparticles from sandalwood (Santalum album L.) extract for efficient catalytic reduction, antioxidant and antibacterial activity

Selvam,

Sudhakar,

Ragu Prasath

2024

Biocatalysis and Agricultural Biotechnology

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Chitosan-based topical formulation integrated with green-synthesized silver nanoparticles utilizing Camellia sinensis leaf extracts: A promising approach for managing infected wounds

Cited by 8 publications

References 73 publications

Silver Nanoparticles Encapped by Dihydromyricetin: Optimization of Green Synthesis, Characterization, Toxicity, and Anti-MRSA Infection Activities for Zebrafish (Danio rerio)

Silver Nanoparticles Encapped by Dihydromyricetin: Optimization of Green Synthesis, Characterization, Toxicity, and Anti-MRSA Infection Activities for Zebrafish (Danio rerio)

Instant green synthesis: obtaining stable nanoparticles and understanding the extract's behavior in the particle formation mechanism

Green synthesis and characterization of silver nanoparticles from sandalwood (Santalum album L.) extract for efficient catalytic reduction, antioxidant and antibacterial activity

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