Chitosan/calcium phosphate flower-like microparticles as carriers for drug delivery platform

Luo, Chao; Wu, Shizhao; Li, Jiao; Li, Xiaoqin; Yang, Peng; Li, Guohua

doi:10.1016/j.ijbiomac.2020.03.172

Cited by 24 publications

(2 citation statements)

References 59 publications

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“…However, it is very difficult to prepare stabilized CaP nanoparticles. In order to improve the stability of CaP nanoparticles, researchers usually use chitosan, hyaluronic acid and other stabilizer during preparation of CaP nanoparticles in water, so as to inhibit the size growth of CaP nanoparticles and the transformation of CaP nanoparticles into calcium phosphate crystals [28,29]. We have found that MCP contains a large number of carboxyl groups, which can bind with Ca 2+ in calcium phosphate under alkaline conditions to increase the stability of CaP nanoparticles.…”

Section: Discussionmentioning

confidence: 99%

MCP mediated active targeting calcium phosphate hybrid nanoparticles for the treatment of orthotopic drug-resistant colon cancer

et al. 2021

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Background Colon cancer is a most common malignant cancer in digestive system, and it is prone to develop resistance to the commonly used chemotherapy drugs, leading to local recurrence and metastasis. Paris saponin VII (PSVII) could not only inhibit the proliferation of colon cancer cells but also effectively induce apoptosis of drug-resistant colon cancer cells and reduce the metastasis of drug-resistant colon cancer cells as well. However, PSVII was insoluble in water and fat. It displayed no selective distribution in body and could cause severe hemolysis. Herein, colon cancer targeting calcium phosphate nanoparticles were developed to carry PSVII to treat drug-resistant colon cancer. Results PSVII carboxymethyl-β-cyclodextrin inclusion compound was successfully encapsulated in colon cancer targeting calcium phosphate nanoparticles (PSVII@MCP-CaP) by using modified citrus pectin as stabilizer agent and colon cancer cell targeting moiety. PSVII@MCP-CaP significantly reduced the hemolysis of PSVII. Moreover, by specific accumulating in orthotopic drug-resistant colon cancer tissue, PSVII@MCP-CaP markedly inhibited the growth of orthotopic drug-resistant colon cancer in nude mice. PSVII@MCP-CaP promoted the apoptosis of drug-resistant colon cancer cells through mitochondria-mediated apoptosis pathway. Moreover, PSVII@MCP-CaP significantly inhibited the invasion and migration of drug-resistant colon cancer cells by increasing E-cadherin protein expression and reducing N-cadherin and MMP-9 protein expression. Conclusion PSVII@MCP-CaP has great potential in the treatment of drug-resistant colon cancer. This study also explores a new method to prepare active targeting calcium phosphate nanoparticles loaded with a fat and water insoluble compound in water. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

MCP mediated active targeting calcium phosphate hybrid nanoparticles for the treatment of orthotopic drug-resistant colon cancer

et al. 2021

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“…Calcium phosphates (CaPs), the mineral elements of bone, can be used in combination with different materials, including metals, like titanium (preferentially as bioactive coating [ 99 , 100 ]), or with polymers. The latter provide composite mixtures to be used as injectable materials (such as acrylic cements) for bone repair and implant fixation [ 101 , 102 ], drug delivery systems [ 103 , 104 ], and scaffolds [ 105 ]. CaPs are mainly represented by hydroxyapatite (HA), β-tricalcium phosphate (β-TCP), and their mixture biphasic calcium phosphate (BCP).…”

Section: Blending Of Pcl-based Biomaterials With Calcium Phosphates T...mentioning

confidence: 99%

New Generation of Osteoinductive and Antimicrobial Polycaprolactone-Based Scaffolds in Bone Tissue Engineering: A Review

Coppola,

Menotti,

Longo

et al. 2024

Polymers

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With respect to other fields, bone tissue engineering has significantly expanded in recent years, leading not only to relevant advances in biomedical applications but also to innovative perspectives. Polycaprolactone (PCL), produced in the beginning of the 1930s, is a biocompatible and biodegradable polymer. Due to its mechanical and physicochemical features, as well as being easily shapeable, PCL-based constructs can be produced with different shapes and degradation kinetics. Moreover, due to various development processes, PCL can be made as 3D scaffolds or fibres for bone tissue regeneration applications. This outstanding biopolymer is versatile because it can be modified by adding agents with antimicrobial properties, not only antibiotics/antifungals, but also metal ions or natural compounds. In addition, to ameliorate its osteoproliferative features, it can be blended with calcium phosphates. This review is an overview of the current state of our recent investigation into PCL modifications designed to impair microbial adhesive capability and, in parallel, to allow eukaryotic cell viability and integration, in comparison with previous reviews and excellent research papers. Our recent results demonstrated that the developed 3D constructs had a high interconnected porosity, and the addition of biphasic calcium phosphate improved human cell attachment and proliferation. The incorporation of alternative antimicrobials—for instance, silver and essential oils—at tuneable concentrations counteracted microbial growth and biofilm formation, without affecting eukaryotic cells’ viability. Notably, this challenging research area needs the multidisciplinary work of material scientists, biologists, and orthopaedic surgeons to determine the most suitable modifications on biomaterials to design favourable 3D scaffolds based on PCL for the targeted healing of damaged bone tissue.

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A Decade of Biomimetic and Bioinspired Nanostructures

Sherawata,

Saini,

Dalal

et al. 2023

Bioinspired and Green Synthesis of Nanostructures

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Chitosan/calcium phosphate flower-like microparticles as carriers for drug delivery platform

Cited by 24 publications

References 59 publications

MCP mediated active targeting calcium phosphate hybrid nanoparticles for the treatment of orthotopic drug-resistant colon cancer

MCP mediated active targeting calcium phosphate hybrid nanoparticles for the treatment of orthotopic drug-resistant colon cancer

New Generation of Osteoinductive and Antimicrobial Polycaprolactone-Based Scaffolds in Bone Tissue Engineering: A Review

A Decade of Biomimetic and Bioinspired Nanostructures

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