Chitosan–Carboxymethylcellulose-Based Polyelectrolyte Complexation and Microcapsule Shell Formulation

Roy, Jagadish Chandra; Ferri, Ada; Giraud, Stéphane; Guan, Jing; Salaün, Fabien

doi:10.3390/ijms19092521

Cited by 50 publications

(25 citation statements)

References 49 publications

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“…Due to chitosan’s exclusive ability to form a polycation, it forms PECs with polyanions [ 37 ], including particularly biopolyanions; alginate, pectin, xanthan gum, gum arabic and carrageenan are the most frequently used PEs [ 100 , 105 ]. However, semisynthetic polymers such as carboxymethylcellulose [ 106 ] and synthetic polymers such as methacrylic acid derivatives [ 107 ] have also been used. PECs based on polysaccharides and their derivatives have aroused great interest for their medical application; compared with chemically crosslinked polymer complexes, PECs based on biopolymers—especially polysaccharides—are generally considered to be nontoxic and biocompatible, and therefore of potential interest for the design of medical devices.…”

Section: Polyelectrolyte Complexesmentioning

confidence: 99%

Naturally Occurring Polyelectrolytes and Their Use for the Development of Complex-Based Mucoadhesive Drug Delivery Systems: An Overview

et al. 2021

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Biopolymers have several advantages for the development of drug delivery systems, since they are biocompatible, biodegradable and easy to obtain from renewable resources. However, their most notable advantage may be their ability to adhere to biological tissues. Many of these biopolymers have ionized forms, known as polyelectrolytes. When combined, polyelectrolytes with opposite charges spontaneously form polyelectrolyte complexes or multilayers, which have great functional versatility. Although only one natural polycation—chitosan has been widely explored until now, it has been combined with many natural polyanions such as pectin, alginate and xanthan gum, among others. These polyelectrolyte complexes have been used to develop multiple mucoadhesive dosage forms such as hydrogels, tablets, microparticles, and films, which have demonstrated extraordinary potential to administer drugs by the ocular, nasal, buccal, oral, and vaginal routes, improving both local and systemic treatments. The advantages observed for these formulations include the increased bioavailability or residence time of the formulation in the administration zone, and the avoidance of invasive administration routes, leading to greater therapeutic compliance.

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Section: Polyelectrolyte Complexesmentioning

confidence: 99%

Naturally Occurring Polyelectrolytes and Their Use for the Development of Complex-Based Mucoadhesive Drug Delivery Systems: An Overview

et al. 2021

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“…Natural anionic polymers have been extensively used for the development of PECs [ 5 , 6 , 7 , 8 ]. However, anionic cellulose derivatives such as hypromellose phthalate [ 4 ] and carboxymethyl cellulose sodium [ 9 ] show greater control of the molecular weight and the number of carboxylic groups (COO − ). Carboxymethyl cellulose sodium (CMC) is a cellulose derivative with good solubility in water.…”

Section: Introductionmentioning

confidence: 99%

“…Carboxymethyl cellulose sodium (CMC) is a cellulose derivative with good solubility in water. CMC has a linear polymer chain and displays polyelectrolyte behavior due to the weak acidic groups in its molecular backbone [ 9 ]. The degree of substitution, which is determined by the number of carboxymethyl groups per unit of CMC, has been widely studied and is one of the main factors affecting its physicochemical behavior [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…CMC has a linear polymer chain and displays polyelectrolyte behavior due to the weak acidic groups in its molecular backbone [ 9 ]. The degree of substitution, which is determined by the number of carboxymethyl groups per unit of CMC, has been widely studied and is one of the main factors affecting its physicochemical behavior [ 9 , 10 ]. Recent studies have shown that the development of matrix tablets containing mixtures of CS and anionic polymers self-assemble during the compression process [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Study of Different Chitosan/Sodium Carboxymethyl Cellulose Proportions in the Development of Polyelectrolyte Complexes for the Sustained Release of Clarithromycin from Matrix Tablets

et al. 2021

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This study investigated the combination of different proportions of cationic chitosan and anionic carboxymethyl cellulose (CMC) for the development of polyelectrolyte complexes to be used as a carrier in a sustained-release system. Analysis via scanning electron microscopy (SEM) Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and powder X-ray diffraction (PXRD) confirmed ionic interactions occur between the chitosan and carboxymethyl cellulose chains, which increases drug entrapment. The results of the dissolution study in acetate buffer (pH 4.2) showed significant increases in the kinetic profiles of clarithromycin for low proportions of chitosan/carboxymethyl cellulose tablets, while the tablets containing only chitosan had high relaxation of chitosan chains and disintegrated rapidly. The Korsmeyer–Peppas kinetic model for the different interpolymer complexes demonstrated that the clarithromycin transport mechanism was controlled by Fickian diffusion. These results suggest that the matrix tablets with different proportions of chitosan/carboxymethyl cellulose enhanced the ionic interaction and enabled the prolonged release of clarithromycin.

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“…The encapsulation step leads, not only to protect the active substance and to prevent leaching, but also to an increase in the specific surface contact area, and therefore, improve the thermal transfer management. Microencapsulation of PCM is mainly carried out via in-situ polymerization [18], interfacial polycondensation [20], sol-gel method [21,22], simple or complex coacervation [23,24], phase separation or suspension process [25,26], and spray drying [27][28][29]. These methods have some drawbacks in the preparation of phase-change microcapsules, such as the complex shell formation process, the use of toxic substances or organic solvent, chemical additives and surfactants, and the difficulty in the control of structure, as well as morphology (i.e., size, shape, and porosity).…”

Section: Introductionmentioning

confidence: 99%

Preparation of n-Alkane/Polycaprolactone Phase-Change Microcapsules via Single Nozzle Electro-Spraying: Characterization on Their Formation, Structures and Properties

2020

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The phase change microcapsule (mPCM) is one of the primary candidates in the fields of energy storage and thermal regulation. In this study, electro-spraying, as a green, high-efficiency electrohydrodynamic atomization technology, is applied to the microencapsulation of two phase change materials (PCM) (n-hexadecane and n-eicosane) with three loading contents (30%, 50%, and 70% by weight) in a polycaprolactone matrix. Ethyl acetate (EA) and chloroform (Chl) were chosen as solvents to prepare the working solutions. The objective of this study is to clarify the microencapsulation process during electro-spraying and to optimize the structure and properties of the electro-sprayed mPCM. The structures, morphologies, and thermal properties of the mPCM were characterized by optical microscopy (OM), scanning electron microscopy (SEM), differential scanning calorimeter (DSC), thermogravimetric analysis (TGA), and fourier transform infrared spectroscopy (FT-IR). Electro-sprayed spherical and non-porous mPCM have been successfully prepared. The mean diameter and the particle size distribution depend mainly on the choice of the n-alkane, as well as the solvent used to prepare the working solutions. Meanwhile, the structure formation of electro-sprayed mPCM and the loading content of PCM were mainly influenced by the evaporation of the solvent and the phase separation between PCM and poly(caprolactone) (PCL) matrix. During the shell formation or PCL solidification, the control of the PCM leaching out of the matrix allows improving the loading content. Finally, based on a high latent heat and simple formation process, the electro-spraying route of PCM is a green, non-toxic, and high-efficiency direction for energy storage and heat regulation.

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Chitosan–Carboxymethylcellulose-Based Polyelectrolyte Complexation and Microcapsule Shell Formulation

Cited by 50 publications

References 49 publications

Naturally Occurring Polyelectrolytes and Their Use for the Development of Complex-Based Mucoadhesive Drug Delivery Systems: An Overview

Naturally Occurring Polyelectrolytes and Their Use for the Development of Complex-Based Mucoadhesive Drug Delivery Systems: An Overview

Study of Different Chitosan/Sodium Carboxymethyl Cellulose Proportions in the Development of Polyelectrolyte Complexes for the Sustained Release of Clarithromycin from Matrix Tablets

Preparation of n-Alkane/Polycaprolactone Phase-Change Microcapsules via Single Nozzle Electro-Spraying: Characterization on Their Formation, Structures and Properties

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