Chitosan-clay nanocomposite as a drug delivery system of ibuprofen

Abstract

Chitosan/montmorillonite nanocomposite films were prepared by the solvent evaporation method to immobilize the drug ibuprofen (IBU) and delay its release in a medium that simulates the environment of the gastrointestinal tract. The effects of montmorillonite, at different mass proportions (10, 20, and 50%), on the morphological and physical properties of the films were studied. The samples were characterized by X-ray diffraction (XRD), Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), degree of swelling, drug encapsulation, and drug release efficiency. According to the XRD it was evidenced that the incorporation of montmorillonite to chitosan led to the formation of nanocomposites of ordered morphology. The infrared spectra confirmed the good interaction between montmorillonite and chitosan by the formation of nanocomposites. This fact, which favored the imprisonment of the IBU, reduced the diffusion coefficient in the studied systems. The micrographs comproved the formation of dense and uniform films. The controlled release profile, especially for the nanocomposite with 10% clay mass, showed a slow drug release rate. The incorporation of montmorillonite at different proportions produced different morphologies, with good encapsulation efficiency and an adequate profile for the controlled release of the drug.

Chitosan‐Based Films in Drug Delivery Applications

“…The film with 10% clay released the drug in a controlled pattern. [ 120 ] Ternary blend films prepared from chitosan, polyvinylpyrrolidine, and guar gum crosslinked with sodium polyphosphate were tested for the release of ciproflaxocin hydrochloride in various buffers mimicking the human body conditions. Controlled release of the drug was found to be excellent in simulated intestinal fluid and phosphate buffer solutions.…”

Nanoclay Reinforced Ternary Blends Based on Biodegradable Polymers for Drug Delivery Application

“…Common biodegradable polymers are polyethylene glycol (PEG), chitosan (CS), poly- ε -caprolactone (PCL), soy protein, and copolymers of polyglycolide, polylactic acid (PLA), poly-3-hydroxybutyrate, polyglycolic acid (PGA), and alginate [ 4 ]. Chitosan is the second most abundantly found polysaccharide in nature and is used to design systems for drug delivery [ 5 ]. Chitosan (CS) possesses much importance because of its nontoxicity, biocompatibility, and biodegradability [ 6 ], and it can be synthesized from chitin [ 7 ].…”