Chitosan-coated alginate micro-particles delivery of active principles through conventional pelleted food - A study in Tilapia (Oreochromis niloticus)

Applications of Chitosan-Alginate-Based Nanoparticles—An Up-to-Date Review

“…Giacomello et al [135] have prepared chitosan-coated alginate microparticles for the oral delivery of immune-prophylactics to finfish. Investigations revealed that the in vivo administration by medicated food protects the microparticles while transiting the stomach, ensuring cargo release in the anterior intestines (i.e., the villum sectum-2 h after feeding, and the basal lamina of epithelial cells-4 h after feeding).…”

Alginate‐based delivery systems for food bioactive ingredients: An overview of recent advances and future trends

“…Microparticles are referred to as approximately spherical particles with diameters between 1−1000 µm, such as microcapsules and microspheres (Agüero et al, 2017). Alginate microparticles can be formulated by various methods typically ionotropic gelation, complex coacervation and spray drying method (Agüero et al, 2017;Giacomello et al, 2020;Haffner & Pasc, 2018). Alginate solution is dropped into a solution containing divalent cation (Ca 2+ ) and this procedure (ionotropic gelation) is generally combined with other techniques in the reported literature (Giacomello et al, 2020).…”

“…Alginate microparticles can be formulated by various methods typically ionotropic gelation, complex coacervation and spray drying method (Agüero et al, 2017;Giacomello et al, 2020;Haffner & Pasc, 2018). Alginate solution is dropped into a solution containing divalent cation (Ca 2+ ) and this procedure (ionotropic gelation) is generally combined with other techniques in the reported literature (Giacomello et al, 2020). Besides, complex coacervation of alginate and chitosan is extensively used (Giacomello et al, 2020), though other oppositely charged polyelectrolytes polycations including zein, caseinate and gelatin are also employed (Song et al, 2020).…”

“…Alginate solution is dropped into a solution containing divalent cation (Ca 2+ ) and this procedure (ionotropic gelation) is generally combined with other techniques in the reported literature (Giacomello et al, 2020). Besides, complex coacervation of alginate and chitosan is extensively used (Giacomello et al, 2020), though other oppositely charged polyelectrolytes polycations including zein, caseinate and gelatin are also employed (Song et al, 2020). However, since hightemperature atomization can lead to the inactivation of temperature-sensitive bioactive compounds, spray freezedrying is now commonly proposed to avoid loss of bioactivity by atomizing solutions containing bioactive substances in low-temperature gases or liquids and then lyophilizing them (Haffner et al, 2018).…”

Preparation and Characterization of Aminoglycoside-Loaded Chitosan/Tripolyphosphate/Alginate Microspheres against E. coli

“…Their large specific surface area favors the interaction with target tissues allowing the direct treatment application directly to tissues, rather than delivery via bodily fluids, keeping the antibiotic effectiveness even if a lower dose is administrated. In this sense, although both synthetic and natural polymers have been employed to obtain microspheres for controlled-release drug delivery [ 12 , 13 , 14 , 15 ], polysaccharide-based ones in their wide diversity have constituted an important research line in recent years, due to their diverse bioactive attributes as well as other functional properties (biocompatibility, stability, etc.) [ 16 ].…”