Chitosan-Coated Alginate Nanoparticles Enhanced Absorption Profile of Insulin Via Oral Administration

Jaafar, Mohd Hafiz Mohd; Hamid, Khuriah Abdul

doi:10.2174/1567201816666190620110748

Cited by 21 publications

(11 citation statements)

References 83 publications

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“…In vitro dissolution tests verified that the matrix CA, the core-sheath structures with different drug concentrations, and also the engineered sheath thicknesses were able to work together in a clearly combined mechanism to ensure a fine sustained release file from nanofibers F2, which had an initial release of 11.3 ± 2.9% in the first hour, released 95% of the loaded MET in 23.4 h, and had a very small late leveling-off release. The present proof-of-concept Oral administration is the most favorable route for the patients [80]. Electrospinning is rapidly moving to the creation of nanofibers on a large scale [81].…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Drug Heterogeneous Distributions within Core-Sheath Nanostructures on Its Sustained Release Profiles

et al. 2021

Biomolecules

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The sustained release of a water-soluble drug is always a key and important issue in pharmaceutics. In this study, using cellulose acetate (CA) as a biomacromolecular matrix, core-sheath nanofibers were developed for providing a sustained release of a model drug—metformin hydrochloride (MET). The core–sheath nanofibers were fabricated using modified tri-axial electrospinning, in which a detachable homemade spinneret was explored. A process—nanostructure–performance relationship was demonstrated through a series of characterizations. The prepared nanofibers F2 could release 95% of the loaded MET through a time period of 23.4 h and had no initial burst effect. The successful sustained release performances of MET can be attributed to the following factors: (1) the reasonable application of insoluble CA as the filament-forming carrier, which determined that the drug was released through a diffusion manner; (2) the core–sheath nanostructure provided the possibility of both encapsulating the drug completely and realizing the heterogeneous distributions of MET in the nanofibers with a higher drug load core than the sheath; (3) the thickness of the sheath sections were able to be exploited for further manipulating a better drug extended release performance. The mechanisms for manipulating the drug sustained release behaviors are proposed. The present proof-of-concept protocols can pave a new way to develop many novel biomolecule-based nanostructures for extending the release of water-soluble drugs.

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Section: Discussionmentioning

confidence: 99%

“…Oral administration is the most favorable route for the patients [80]. Electrospinning is rapidly moving to the creation of nanofibers on a large scale [81].…”

Section: Combined Strategy For Providing Sustained Release Of Water-soluble Drugmentioning

confidence: 99%

The Effect of Drug Heterogeneous Distributions within Core-Sheath Nanostructures on Its Sustained Release Profiles

et al. 2021

Biomolecules

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“…The animals were fasted overnight, 12 h prior to the start of experiment with water ad libitum and prepared according to the method previously reported [ 31 ]. The rats were randomized to be administered orally (30 mg/kg) with either nanoemulsion, microemulsion and control formulation, respectively.…”

Section: Methodsmentioning

confidence: 99%

Development and characterisation of ibuprofen-loaded nanoemulsion with enhanced oral bioavailability

Anuar

Sabri

Effendi

et al. 2020

Heliyon

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Lipophilic compounds constitute a majority of therapeutics in the pipeline of drug discovery. Despite possessing enhanced efficacy and permeability, some of these drugs suffer poor solubility necessitating the need of a suitable drug delivery system. Nanoemulsion is a drug delivery system that provides enhanced solubility for poorly soluble drugs in an attempt to improve the oral bioavailability. The purpose of this study is to develop a nanoemulsion system using ibuprofen as a model drug in order to investigate the potential of this colloidal system to enhance the absorption of poorly water-soluble drugs. Ibuprofen loaded-nanoemulsion with different drug concentrations (1.5, 3 and 6% w/w) were formulated from olive oil, sucrose ester L-1695 and glycerol using D-phase emulsification technique. A pseudoternary phase diagram was utilised to identify the optimal excipient composition to formulate the nanoemulsion system. In vitro diffusion chamber studies using rodent intestinal linings highlighted improved absorption profile when ibuprofen was delivered as nanoemulsion in comparison to microemulsions and drug-in-oil systems. This was further corroborated by in vivo studies using rat model that highlighted a two-fold increase in ibuprofen absorption when the drug was administered as a nanoemulsion relative to drug-in-oil system. On the other hand, when ibuprofen was administered as microemulsions, only a 1.5-fold increase in absorption was observed relative to drug-in-oil system. Thus, this study highlights the potential of using nanoemulsion as a drug delivery system to enhance the oral bioavailability of hydrophobic drugs.

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“…Chitosan may enhance drug permeation by opening of tight junctions which is highly related to CLDN4 [73]. Chitosan will modulate CLDN4 protein redistribution to the cytosol and disrupt tight junctions [62].…”

Section: Efflux Pump Inhibitionmentioning

confidence: 99%

Chitosan-Based Oral Drug Delivery System for Peptide, Protein and Vaccine Delivery

Zainuddin¹,

Hamid²

2021

Chitin and Chitosan - Physicochemical Properties and Industrial Applications [Working Title]

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Oral delivery is the most common and preferred route of drug administration due to its convenience and ease of administration. However, various factors such as poor solubility, low dissolution rate, stability, and bioavailability of many drugs remain an ongoing challenge in achieving desired therapeutic levels. The delivery of drugs must overcome various obstacles, including the acidic gastric environment, the presence of the intestinal efflux and influx transporters and the continuous secretion of mucus that protects the gastrointestinal tract (GIT). As the number and chemical diversity of drugs has increased, various strategies are required to develop orally active therapeutics. One of the approaches is to use chitosan as a carrier for oral delivery of peptides, proteins as well as vaccines delivery. Chitosan, a non-toxic N-deacetylated derivative of chitin appears to be under intensive progress during the last years towards the development of safe and efficient chitosan-based drug delivery systems. This polymer has been recognised as a versatile biomaterial because of its biodegradability, biocompatibility, and non-toxicity. This chapter reviews the physicochemical characteristics of chitosan and the strategies that have been successfully applied to improve oral proteins, peptides, and vaccines bioavailability, primarily through various formulation strategies.

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Chitosan-Coated Alginate Nanoparticles Enhanced Absorption Profile of Insulin Via Oral Administration

Cited by 21 publications

References 83 publications

The Effect of Drug Heterogeneous Distributions within Core-Sheath Nanostructures on Its Sustained Release Profiles

The Effect of Drug Heterogeneous Distributions within Core-Sheath Nanostructures on Its Sustained Release Profiles

Development and characterisation of ibuprofen-loaded nanoemulsion with enhanced oral bioavailability

Chitosan-Based Oral Drug Delivery System for Peptide, Protein and Vaccine Delivery

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