Chitosan coated alginate/poly(N-isopropylacrylamide) beads for dual responsive drug delivery

Sun, Ximeng; Shi, Jun; Xu, Xiaodan; Cao, Shaokui

doi:10.1016/j.ijbiomac.2013.04.066

Cited by 51 publications

(24 citation statements)

References 32 publications

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“…This outcome was in agreement with the result of caffeine release from freeze‐dried microcapsules in simulated mouth conditions, where alginate microcapsules with chitosan coating had the slowest caffeine release profiles (Figure ), in contrast to other carrier matrices. These results are corroborated by those found in the literature …”

Section: Resultssupporting

confidence: 92%

“…As the chitosan coating around the alginate matrix was strong and uniform, so it is obvious that this membrane retarded the release rate of caffeine from freeze-dried microcapsules in artificial saliva. Sun et al 28 and Yang et al 42 have also reported that drugs entrapped in alginate capsules coated with chitosan had retarded diffusion rates, compared with alginate capsules without chitosan. Thus, compared with alginate with chitosan coating, the chitosan layer around the alginate microcapsules appropriately retard the release of caffeine to the outside.…”

Section: The Release Profile Of Caffeine From Microcapsules In Simumentioning

confidence: 99%

“…The electrostatic interaction of the negatively charged carboxylic acid groups of alginate with the positively charged amino groups of chitosan results in the formation of the alginate-chitosan membrane. 16,26 Chitosan-coated alginate capsules have been widely used for drug delivery systems, 21,27,28 and in the encapsulation of probiotic bacteria. [29][30][31] Whey protein isolate is a valuable by-product of dairy manufacturing.…”

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confidence: 99%

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Development of caffeine‐encapsulated alginate‐based matrix combined with different natural biopolymers, and evaluation of release in simulated mouth conditions

Mohammadi

Ehsani

Bakhoda

2018

Flavour & Fragrance J

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Caffeine was encapsulated into calcium alginate microcapsules, and these microcapsules were produced with four types of material – starch, xanthan, chitosan, and whey protein isolate – in combination with alginate. Formulation characteristics such as the efficiency of microencapsulation, microcapsule size, viscosity, and texture properties of the microcapsules have been evaluated. The release of caffeine from different microcapsules was conducted in simulated saliva fluid. Alginate microcapsules with chitosan coating provided the slowest release of caffeine, compared with the other microcapsules. Significant differences in the appearance of the microcapsules were detectable by scanning electron microscopy (SEM) and optical microscopy. Fourier‐transform infrared spectrometry (FTIR) analysis confirmed the existence of carbonyl groups in caffeine‐loaded microcapsules, and differential scanning calorimetry (DSC) thermograms indicated the glass transition temperature of the microcapsules. This study showed that the microencapsulation of caffeine with alginate may be helpful for designing fast (alginate) as well as prolonged caffeine release (alginate–starch–xanthan with chitosan).

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Section: Resultssupporting

confidence: 92%

Section: The Release Profile Of Caffeine From Microcapsules In Simumentioning

confidence: 99%

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confidence: 99%

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Development of caffeine‐encapsulated alginate‐based matrix combined with different natural biopolymers, and evaluation of release in simulated mouth conditions

Mohammadi

Ehsani

Bakhoda

2018

Flavour & Fragrance J

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“…Sun et al, 18 also observed the same from the CS coated alginate/poly(N-isopropylacrylamide) beads for dual responsive drug delivery. Table 2, and the value lies in between 49.56% to 63.74%, percentage of EE decreased due to insolubility of CT in water.…”

Section: Fig 6: Scanning Electronic Microscopic Images Of Xg-g-msb (mentioning

confidence: 80%

“…Drug encapsulation efficiency decreases due to larger pores that may result in leakage of an entrapped drug into the external medium 17 . Burst release of the drug from the natural hydrogels is due to the breakdown of beads in-vitro conditions 18 . In order to solve these problems currently much effort has been spent on improving the gel beads.…”

Section: Ijpsr (2020) Volume 11 Issue 3 (Research Article)mentioning

confidence: 99%

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2020

IJPSR

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In the present work, temperature/pH-sensitive copolymer beads of chitosan (CS) coated sodium alginate/xanthan gum grafted N, N'methylenediacrylamide have been synthesized by free radical polymerization in an atmosphere of nitrogen using AIBN/Fe 2+ redox pair initiator and Tetramethylethylenediamine (TEMED) as a catalyst followed by simple ionotropic gelation technique. These beads were characterized by Fourier transform infrared (FTIR) spectroscopy, Differential scanning calorimetry (DSC), Field emission scanning electron microscopy (FESEM) Energydispersive X-ray spectra (EDS) and X-ray diffraction measurements (X-RD). DSC and X-RD studies reveal the molecular dispersion of Chlorthalidone (CT) drugs. Swelling and drug release behaviors of these beads were investigated in simulated intestinal fluid (pH 7.4) and gastric fluid (pH 2.0) at 37 ºC. Results illustrated that both the swelling and degradation of the optimized beads were influenced by the pH of the test medium, which might be suitable for intestinal drug delivery. The release mechanism was analyzed by fitting the release data into the Korsmeyer-Peppas equation.

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Smart carboxymethylchitosan hydrogels that have thermo‐ and pH‐responsive properties

Rodkate

Rutnakornpituk

Wichai

et al. 2014

J of Applied Polymer Sci

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Thermo-responsive poly(N-isopropylacrylamide) (poly(NIPAAm)) and pH-responsive poly(N,N 0 -diethylaminoethyl methacrylate) (poly(DEAEMA)) polymers were grafted to carboxymethylchitosan (CMC) via radical polymerization to form highly water swellable hydrogels with dual responsive properties. Ratios of CMC, NIPAAm to DEAEMA used in the reactions were finely adjusted such that the thermo and pH responsiveness of the hydrogels was retained. Scanning electron microscopy (SEM) indicated the formation of an internal porous structure for the swollen CMC hydrogels upon incorporation of poly(NIPAAm) and poly(DEAEMA). Effect of temperature and pH changes on water swelling properties of the hydrogels was investigated. It was found that the water swelling of the hydrogels was enhanced when the solution pH was under basic conditions (pH 11) or the temperature was below its lower critical solution temperature (LCST). These responsive properties can be used to regulate releasing rate of an entrapped drug from the hydrogels, a model drug, indomethacin was used to demonstrate the release. These smart and nontoxic CMC-based hydrogels show great potential for use in controlled drug release applications with controllable on-off switch properties. V C 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41505. Poly(NIPAAm) is a thermo-sensitive polymer and is one of the most studied smart polymers. Poly(NIPAAm) exhibits phase separation at a certain temperature, which is referred to as the lower critical solution temperature (LCST). Poly(NIPAAm) has a LCST of about 32 C in aqueous solution. 9,14-17 When the temperature is below its LCST, poly(NIPAAm) is hydrophilic and soluble in water. The polymer chains are well hydrated and Additional Supporting Information may be found in the online version of this article

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Chitosan coated alginate/poly(N-isopropylacrylamide) beads for dual responsive drug delivery

Cited by 51 publications

References 32 publications

Development of caffeine‐encapsulated alginate‐based matrix combined with different natural biopolymers, and evaluation of release in simulated mouth conditions

Development of caffeine‐encapsulated alginate‐based matrix combined with different natural biopolymers, and evaluation of release in simulated mouth conditions

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Smart carboxymethylchitosan hydrogels that have thermo‐ and pH‐responsive properties

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