Chitosan-coated poly(є-caprolactone) nanocapsules for mucoadhesive applications of perillyl alcohol

Penteado, Larissa de O.; Lopes, Vanessa F.; Karam, Thaysa Ksiaskiewcz; Nakamura, Celso Vataru; Khalil, Najeh Maissar; Mainardes, Rubiana Mara

doi:10.1080/1539445x.2021.1906702

Cited by 8 publications

(5 citation statements)

References 46 publications

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“…This disappearance indicates successful encapsulation of the active ingredient into nanoparticles 68 , 69 . These results are in accordance with what was previously reported by Penteado et al where the melting peak of perillyl alcohol disappeared after its incorporation in chitosan coated PCL nanocapsules 70 .…”

Section: Discussionsupporting

confidence: 94%

Exploring the potential of intranasally administered naturally occurring quercetin loaded into polymeric nanocapsules as a novel platform for the treatment of anxiety

Mahmoud

Elhesaisy

Rashed

et al. 2023

Sci Rep

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Anxiety is one of the most prevalent forms of psychopathology that affects millions worldwide. It gained more importance under the pandemic status that resulted in higher anxiety prevalence. Anxiolytic drugs such as benzodiazepines have an unfavorable risk/benefit ratio resulting in a shift toward active ingredients with better safety profile such as the naturally occurring quercetin (QRC). The delivery of QRC is hampered by its low water solubility and low bioavailability. The potential to enhance QRC delivery to the brain utilizing polymeric nanocapsules administered intranasally is investigated in the current study. Polymeric nanocapsules were prepared utilizing the nanoprecipitation technique. The best formula displayed a particle size of 227.8 ± 11.9 nm, polydispersity index of 0.466 ± 0.023, zeta potential of − 17.5 ± 0.01 mV, and encapsulation efficiency % of 92.5 ± 1.9%. In vitro release of QRC loaded polymeric nanocapsules exhibited a biphasic release with an initial burst release followed by a sustained release pattern. Behavioral testing demonstrated the superiority of QRC loaded polymeric nanocapsules administered intranasally compared to QRC dispersion administered both orally and intranasally. The prepared QRC loaded polymeric nanocapsules also demonstrated good safety profile with high tolerability.

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Section: Discussionsupporting

confidence: 94%

Exploring the potential of intranasally administered naturally occurring quercetin loaded into polymeric nanocapsules as a novel platform for the treatment of anxiety

Mahmoud

Elhesaisy

Rashed

et al. 2023

Sci Rep

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show abstract

“…This disappearance indicates successful encapsulation of the active ingredient into nanoparticles [54]. These results are in accordance with what was previously reported by Penteado et al where the melting peak of perillyl alcohol disappeared after its incorporation in chitosan coated PCL nanocapsules [55].…”

Section: Discussionsupporting

confidence: 92%

Exploring the Potential of Intranasally Administered Naturally Occurring Quercetin Loaded into Polymeric Nanocapsules as a Novel Platform for the Treatment of Anxiety

Mahmoud

Elhesaisy

Rashed

et al. 2022

Preprint

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Anxiety is one of the most prevalent forms of psychopathology that affects millions worldwide. It gains more importance under the current pandemic status that resulted in higher anxiety prevalence. Anxiolytic drugs such as benzodiazepines have an unfavorable risk/benefit ratio resulting in a shift toward active ingredients with better safety profile such as the naturally occurring quercetin. The delivery of quercetin is hampered by its low water solubility and low bioavailability. The potential of enhancing quercetin delivery to the brain utilizing polymeric nanocapsules administered nasally is investigated in the current study. Polymeric nanocapsules were prepared utilizing the nanoprecipitation technique. The best formula displayed a particle size of 227.8 ± 11.9, Polydispersity index of 0.466 ± 0.023, zeta potential of -17.5 ± 0.01, and encapsulation efficiency % of 92.5 ± 1.9. The prepared nanoparticles displayed In vitro release of QRC loaded polymeric nanocapsules exhibited a biphasic release with an initial burst release followed by a sustained release pattern. The in vivo evaluation demonstrated the superiority of quercetin polymeric nanocapsules administered intranasally compared quercetin dispersion administered both orally and intranasally. The prepared nanocapsules also demonstrated good safety profile with high tolerability.

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“…The obtained NLCs showed a zeta potential of −32.5 mV, indicating excellent predictability of formulation stability. This highly negative value suggests strong repulsive forces among the particles, effectively preventing internal phase aggregation [ 42 ]. The anionic nature of the solid lipid Gelucire ® 43/01 is responsible for conferring the negative charge, which contributes to the zeta potential observed.…”

Section: Resultsmentioning

confidence: 99%

Enhancing Oral Bioavailability and Brain Biodistribution of Perillyl Alcohol Using Nanostructured Lipid Carriers

Peczek,

Tartari,

Zittlau

et al. 2023

Pharmaceuticals

Self Cite

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Perillyl alcohol (POH), a bioactive monoterpenoid derived from limonene, shows promise as an antitumor agent for brain tumor treatment. However, its limited oral bioavailability and inadequate brain distribution hinder its efficacy. To address these challenges, this study developed nanostructured lipid carriers (NLCs) loaded with POH to improve its brain biodistribution. The NLCs prepared using hot homogenization exhibited an average diameter of 287 nm and a spherical morphology with a polydispersity index of 0.143. High encapsulation efficiency of 99.68% was achieved. X-ray diffraction analyses confirmed the semicrystalline state of POH-loaded NLCs. In vitro release studies demonstrated a biphasic release profile. Stability studies in simulated gastric and intestinal fluids confirmed their ability to withstand pH variations and digestive enzymes. In vivo pharmacokinetic studies in rats revealed significantly enhanced oral bioavailability of POH when encapsulated in the NLCs. Biodistribution studies showed increased POH concentration in brain tissue with NLCs compared with free POH, which was distributed more in non-target tissues such as the liver, lungs, kidneys, and spleen. These findings underscore the potential of NLCs as effective delivery systems for enhancing oral bioavailability and brain biodistribution of POH, providing a potential therapeutic strategy for brain tumor treatment.

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Chitosan-coated poly(є-caprolactone) nanocapsules for mucoadhesive applications of perillyl alcohol

Cited by 8 publications

References 46 publications

Exploring the potential of intranasally administered naturally occurring quercetin loaded into polymeric nanocapsules as a novel platform for the treatment of anxiety

Exploring the potential of intranasally administered naturally occurring quercetin loaded into polymeric nanocapsules as a novel platform for the treatment of anxiety

Exploring the Potential of Intranasally Administered Naturally Occurring Quercetin Loaded into Polymeric Nanocapsules as a Novel Platform for the Treatment of Anxiety

Enhancing Oral Bioavailability and Brain Biodistribution of Perillyl Alcohol Using Nanostructured Lipid Carriers

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