Chitosan-coated zein nanoparticles for oral delivery of resveratrol: Formation, characterization, stability, mucoadhesive properties and antioxidant activity

Pauluk, Daniele; Padilha, Ariane Krause; Khalil, Najeh Maissar; Mainardes, Rubiana Mara

doi:10.1016/j.foodhyd.2019.03.042

Cited by 148 publications

(82 citation statements)

References 34 publications

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“…When resveratrol was loaded by zein–pectin core / shell nanoparticles, they became stable to aggregation from pH 2 to 7 and exhibited good heat stability . Similar results were obtained by other groups . Liang et al .…”

Section: Stabilitysupporting

confidence: 79%

Resveratrol: a review of plant sources, synthesis, stability, modification and food application

2019

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Resveratrol, a stilbene molecule belonging to the polyphenol family, is usually extracted from a great many natural plants. The technologies of preparation and extraction methods are developing rapidly. As resveratrol has many beneficial properties, it has been widely utilized in food and medicine industry. In terms of its structure, it is susceptible to degradation and can undergo chemical changes during food processing. Different studies have therefore given more attention to various aspects of resveratrol, including anti-aging, anti-oxidant, and anti-cancer activity. This review classifies the study of resveratrol, considers plant sources, synthesis, stability, common reactions, and food applications, and provides references to boost its food and medical utilization. SYNTHESISSince the discovery of natural resveratrol by researchers, chemist have made many attempts at the chemical synthesis / biosynthesis of resveratrol (Fig. 2). 15

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Section: Stabilitysupporting

confidence: 79%

Resveratrol: a review of plant sources, synthesis, stability, modification and food application

2019

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“…The PDI values of αand β-chitosan nanoparticles were in the range of 0.168-0.314 and 0.098-0.248, respectively. In case of nanoparticles, a PDI below 0.3 is desired, since values higher than 0.3 indicate low uniformity, being an indication of aggregation [37]. Figure 4b demonstrates that the PDIs of α-and β-chitosan nanoparticles were significantly and positively correlated with the MW of the chitosan (r = 0.766, p < 0.01), but negatively correlated with %DD (r = −0.602, p < 0.01) as seen in Figure 4c, and particle size (r = −0.469, p < 0.05) as seen in Figure 4d.…”

Section: Particle Size Polydispersity Index (Pdi) and Zeta Potentialmentioning

confidence: 99%

“…The higher MW of chitosan resulted in the higher PDI of either the αor β-chitosan nanoparticle size distribution. From Table 2, only the aNP1 sample showed a PDI greater than 0.3 which could have resulted from using high MW chitosan, which may be able to entangle into a higher polydispersity sample with multiple particle size populations [37]. The sizes of α-and β-chitosan nanoparticles were in the range of 165 to 332 nm and 170 to 232 nm, respectively.…”

Section: Particle Size Polydispersity Index (Pdi) and Zeta Potentialmentioning

confidence: 99%

Impact of Crystalline Structural Differences Between α- and β-Chitosan on Their Nanoparticle Formation Via Ionic Gelation and Superoxide Radical Scavenging Activities

2019

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α- and β-Chitosan nanoparticles were obtained from shrimp shell and squid pen chitosan with different set of deacetylation degree (%DD) and molecular weight (MW) combinations. After nanoparticle formation via ionic gelation with sodium tripolyphosphate (TPP), the % crystallinity index (%CI) of the α- and β-chitosan nanoparticles were reduced to approximately 33% and 43% of the initial %CI of the corresponding α- and β-chitosan raw samples, respectively. Both forms of chitosan and chitosan nanoparticles scavenged superoxide radicals in a dose-dependent manner. The %CI of α- and β-chitosan and chitosan nanoparticles was significantly negatively correlated with superoxide radical scavenging abilities over the range of concentration (0.5, 1, 2 and 3 mg/mL) studied. High %DD, and low MW β-chitosan exhibited the highest superoxide radical scavenging activity (p < 0.05). α- and β-Chitosan nanoparticles prepared from high %DD and low MW chitosan demonstrated the highest abilities to scavenge superoxide radicals at 2.0–3.0 mg/mL (p < 0.05), whereas α-chitosan nanoparticles, with the lowest %CI, and smallest particle size (p < 0.05), prepared from medium %DD, and medium MW chitosan showed the highest abilities to scavenge superoxide radicals at 0.5–1.0 mg/mL (p < 0.05). It could be concluded that α- and β-chitosan nanoparticles had superior superoxide radical scavenging abilities than raw chitosan samples.

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“…Cs-SLN dispersion was incubated with mucin solutions for 30 min in a shaker at 70 rpm, 37°C. Particle size, PDI, Zeta potential were recorded before and after the incubation period (Pauluk et al, 2019 ).…”

Section: Methodsmentioning

confidence: 99%

Recuperating Biopharmaceutical Aspects of Amphotericin B and Paromomycin Using a Chitosan Functionalized Nanocarrier via Oral Route for Enhanced Anti-leishmanial Activity

Parvez

Yadagiri

Karole

et al. 2020

Front. Cell. Infect. Microbiol.

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The design and development of new pharmaceutical formulations for the existing anti-leishmanial is a new strategic alternate to improve efficacy and safety rather than new drug discovery. Herein hybrid solid lipid nanoparticles (SLN) have been engineered to direct the oral delivery of two anti-leishmanial drugs amphotericin B (AmB) and paromomycin (PM). The combinatorial nanocarriers consist of conventional SLN, antileishmanial drugs (AmB and PM) which have been functionalized with chitosan (Cs) grafted onto the external surface. The Cs-SLN have the mean particle size of 373.9 ± 1.41 nm, polydispersity index (PDI) of 0.342 ± 0.02 and the entrapment efficiency for AmB and PM was found to be 95.20 ± 3.19% and 89.45 ± 6.86 %, respectively. Characterization of SLN was performed by scanning electron microscopy and transmission electron microscopy. Complete internalization of the formulation was observed in Caco-2 cells. Cs-SLN has shown a controlled and slow drug release profile over a period of 72 h and was stable at gastrointestinal fluids, confirmed by simulated gastro-intestinal fluids study. Cs coating enhanced the mucoadhesive property of Cs-SLN. The in-vitro anti-leishmanial activity of Cs-SLN (1 μg/ml) has shown a maximum percentage of inhibition (92.35%) on intra-cellular amastigote growth of L. donovani .

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Chitosan-coated zein nanoparticles for oral delivery of resveratrol: Formation, characterization, stability, mucoadhesive properties and antioxidant activity

Cited by 148 publications

References 34 publications

Resveratrol: a review of plant sources, synthesis, stability, modification and food application

Resveratrol: a review of plant sources, synthesis, stability, modification and food application

Impact of Crystalline Structural Differences Between α- and β-Chitosan on Their Nanoparticle Formation Via Ionic Gelation and Superoxide Radical Scavenging Activities

Recuperating Biopharmaceutical Aspects of Amphotericin B and Paromomycin Using a Chitosan Functionalized Nanocarrier via Oral Route for Enhanced Anti-leishmanial Activity

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