Chitosan conjugates with biologically active compounds: design strategies, properties, and targeted drug delivery

Березин, А. С.; Lomkova, E. A.; Skorik, Yury А.

doi:10.1007/s11172-012-0109-3

Cited by 33 publications

(10 citation statements)

References 130 publications

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“…Chitosans that are fi nding increasing applications in medicine and pharmacology [1][2][3] are linear copolymers containing D -glucosamine and N-acetyl-D -glucosamine units linked by (1→4)-β-glycoside bonds. Chitosans of different molecular weight and degree of acetylation (DA) are obtained by a base-catalyzed hydrolysis of a natural Salt anions can either suppress chitosan's aggregation (as in ammonium acetate buffer) [ 9 ] or affect the aggregation in a different way.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of Clusters and Unimers in Associating Solutions of Chitosan by Dynamic and Static Light Scattering

Skorik

Петрова

Okatova

et al. 2016

Macro Chemistry & Physics

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Association of two chitosans of different degrees of acetylation (DA) is studied in dilute water/acid/salt solutions by combined analysis of static and dynamic light scattering. The influence of sodium salt anions Cl − and CH 3 COO − on conformation of macromolecules and properties of clusters was studied. At DA = 15 mol%, the macromolecules exist either in rigid-rod (R g /R h = 2.7) or in coil (R g /R h = 1.8) conformations in the solvents containing NaCl and CH 3 COONa, respectively. Chitosans with higher DA = 28% dissolved in the solvent containing CH 3 COONa are in the collapsed state (R g /R h < 0.8), predicted by Dobrynin (Macromolecules, 2004). The clusters are of spherical form (0.8 < R g /R h < 1.2). CH 3 COONa promotes higher fractal dimensionality of clusters (2.2-2.4) than NaCl (1.9). Higher critical aggregation concentration is observed in NaCl. The other hydrodynamic methods (capillary viscometry, velocity sedimentation, and Tsvetkov diffusometry) do not detect the clusters, probably, because of their disruption during flow.

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Section: Introductionmentioning

confidence: 99%

“…Concentration dependence of fraction of light scattered by the clusters of Cs-15 in AcOH/AcONa(1) and AcOH/NaCl(2).…”

mentioning

confidence: 99%

Characterization of Clusters and Unimers in Associating Solutions of Chitosan by Dynamic and Static Light Scattering

Skorik

Петрова

Okatova

et al. 2016

Macro Chemistry & Physics

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“…Vectors can be conjugated to the polymer to allow for targeted delivery of the biopharmaceutical. Th ese vectors can be biologically active substances (BAS) where the method of conjugation depends on several factors such as the mechanism of therapeutic eff ect, the ideal fi nal structure of the biopolymer and the nature of the BAS [118]. Chitosan-based nanoparticles have been used in the transport of peptides, antigens and plasmid DNA among others.…”

Section: Targeted Delivery Agentsmentioning

confidence: 99%

“…Th e gel was found to have a sustained in vivo release profi le which was desirable for this application [126]. Berezin et al reviewed the utility of chitosan and its derivatives in targeted drug delivery [118]. Th is review reported on the use of chitosan based compounds such as carboxymethylchitosan, hydroxypropylchitosan, histidine-chitosan and PEG-chitosan for the delivery of conjugated BAS which included doxorubicin, oligodeoxynucleotides and pDNA [118].…”

Section: Targeted Delivery Agentsmentioning

confidence: 99%

“…Berezin et al reviewed the utility of chitosan and its derivatives in targeted drug delivery [118]. Th is review reported on the use of chitosan based compounds such as carboxymethylchitosan, hydroxypropylchitosan, histidine-chitosan and PEG-chitosan for the delivery of conjugated BAS which included doxorubicin, oligodeoxynucleotides and pDNA [118]. Ramesan et al looked at gene delivery using modifi ed chitosan nanoparticles [127].…”

Section: Targeted Delivery Agentsmentioning

confidence: 99%

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Chitosan as an Advanced Healthcare Material

Jardine

Sayed

2014

Advanced Biomaterials and Biodevices

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Chitin and chitosan are renewable biopolymers with inherently favourable properties allowing diverse chemical modifi cation that generates novel materials ideal for biomedical applications. Chitin itself has very poor aqueous solubility and hence found limited utility. For this reason the use of chitosan, in particular, modifi ed chitosan, has increased exponentially in biomedical applications in recent years. Th e review of chitosan as a health care material includes wound healing or tissue regeneration, drug delivery and antimicrobial studies. Specialist applications are vast and due to the shortened publication process, biomedical applications of chitosan may warrant more frequent reviews.In this review, highlights of recent research on the synthesis and analysis of chitin and chitosan based nanomaterials and nanofi bres will be covered. A detailed review of the synthetic transformation of chitosan that further added value by enabling diverse application has been discussed. Th e value of copolymerization and graft ing of biodegradable synthetic polymers with chitosan in order to improve stability and control of the functional biomaterial has been a major driver in the biotechnological innovation.

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ChemInform Abstract: Chitosan Conjugates with Biologically Active Compounds: Design Strategies, Properties, and Targeted Drug Delivery

2013

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Chitosan conjugates with biologically active compounds: design strategies, properties, and targeted drug delivery

Cited by 33 publications

References 130 publications

Characterization of Clusters and Unimers in Associating Solutions of Chitosan by Dynamic and Static Light Scattering

Characterization of Clusters and Unimers in Associating Solutions of Chitosan by Dynamic and Static Light Scattering

Chitosan as an Advanced Healthcare Material

ChemInform Abstract: Chitosan Conjugates with Biologically Active Compounds: Design Strategies, Properties, and Targeted Drug Delivery

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