Chitosan-decorated nanoparticles for drug delivery

Prado-Audelo, María Luisa Del; Caballero-Florán, Isaac H.; Sharifi‐Rad, Javad; Mendoza‐Muñoz, Néstor; González‐Torres, Maykel; Urbán-Morlán, Zaida; Florán, Benjamí­n; Cortés, Hernán; Leyva-Gómez, Gerardo

doi:10.1016/j.jddst.2020.101896

Cited by 59 publications

(36 citation statements)

References 97 publications

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“…Meanwhile, Ko and Kim (2020) compared the chemical crosslinking of chitosan and epichlorohydrin with the ionic crosslinking in the presence of itaconic acid to demonstrate advantages of the ionic liquid such as a negligible vapor pressure, high thermal and chemical stability, good recyclability, high electrical conductivity, and good solubility [ 61 , 68 , 82 ]. Other modifications of chitin/chitosan include the substitution of silver nanoparticles [ 65 ], vancomycin [ 83 ], metal organic frameworks [ 22 ], nano silicon/particles [ 11 , 66 , 84 ], and polybenzoxazine/clay [ 44 ]. For applications in the adsorption of pollutants, chitin/chitosan have been modified with glutaraldehyde, formaldehyde, tripolyphosphate, polyaspartic acid sodium salt, and persulfate [ 85 ].…”

Section: Preparation Of Porous Polysaccharidesmentioning

confidence: 99%

Recent Progress in Polysaccharide Aerogels: Their Synthesis, Application, and Future Outlook

Muhammad¹,

Lee²,

Shin³

et al. 2021

Polymers

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Porous polysaccharides have recently attracted attention due to their porosity, abundance, and excellent properties such as sustainability and biocompatibility, thereby resulting in their numerous applications. Recent years have seen a rise in the number of studies on the utilization of polysaccharides such as cellulose, chitosan, chitin, and starch as aerogels due to their unique performance for the fabrication of porous structures. The present review explores recent progress in porous polysaccharides, particularly cellulose and chitosan, including their synthesis, application, and future outlook. Since the synthetic process is an important aspect of aerogel formation, particularly during the drying step, the process is reviewed in some detail, and a comparison is drawn between the supercritical CO2 and freeze drying processes in order to understand the aerogel formation of porous polysaccharides. Finally, the current applications of polysaccharide aerogels in drug delivery, wastewater, wound dressing, and air filtration are explored, and the limitations and outlook of the porous aerogels are discussed with respect to their future commercialization.

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Section: Preparation Of Porous Polysaccharidesmentioning

confidence: 99%

Recent Progress in Polysaccharide Aerogels: Their Synthesis, Application, and Future Outlook

Muhammad¹,

Lee²,

Shin³

et al. 2021

Polymers

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“…Mechanistically, this process oen takes place in three consecutive steps: diffusion, attachment, and rearrangement/relaxation. 35 Chitosan coating has proven to be useful in modifying the supercial characteristics of MOFs and improve their physicochemical properties. 25 3.3.3 Zeta potential.…”

Section: Characterization Of Cs-mofmentioning

confidence: 99%

Chitosan modified metal–organic frameworks as a promising carrier for oral drug delivery

Han

Zhao

et al. 2020

RSC Adv.

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“…Although gradually it could also produce toxicity and opsonization with blood proteins. Additionally, the decoration with chitosan enhances hydrophilicity favoring stability in aqueous environments and improving the facility to explore more administration strategies [14].…”

Section: Decoration Of Nanoparticles With Chitosan: Methods and Mechamentioning

confidence: 99%

“…In this respect, diverse approaches have been proposed in recent years for the passage of drugs across the BBB, and nanoparticles have attracted significant attention for this purpose [8][9][10][11][12][13]. Particularly, chitosan-decorated nanoparticles have demonstrated strong potential for drug delivery to the brain [14]. Chitosan is a polymer natural widely utilized in different applications and approved for human use; it is a biodegradable, biocompatible, non-toxic, non-allergenic, and low-priced biomaterial; thus, chitosan is a suitable material for medical purposes [15].…”

Section: Introductionmentioning

confidence: 99%

A Reevaluation of Chitosan-Decorated Nanoparticles to Cross the Blood-Brain Barrier

et al. 2020

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The blood-brain barrier (BBB) is a sophisticated and very selective dynamic interface composed of endothelial cells expressing enzymes, transport systems, and receptors that regulate the passage of nutrients, ions, oxygen, and other essential molecules to the brain, regulating its homeostasis. Moreover, the BBB performs a vital function in protecting the brain from pathogens and other dangerous agents in the blood circulation. Despite its crucial role, this barrier represents a difficult obstacle for the treatment of brain diseases because many therapeutic agents cannot cross it. Thus, different strategies based on nanoparticles have been explored in recent years. Concerning this, chitosan-decorated nanoparticles have demonstrated enormous potential for drug delivery across the BBB and treatment of Alzheimer’s disease, Parkinson’s disease, gliomas, cerebral ischemia, and schizophrenia. Our main objective was to highlight the high potential of chitosan adsorption to improve the penetrability through the BBB of nanoformulations for diseases of CNS. Therefore, we describe the BBB structure and function, as well as the routes of chitosan for crossing it. Moreover, we define the methods of decoration of nanoparticles with chitosan and provide numerous examples of their potential utilization in a variety of brain diseases. Lastly, we discuss future directions, mentioning the need for extensive characterization of proposed nanoformulations and clinical trials for evaluation of their efficacy.

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Chitosan-decorated nanoparticles for drug delivery

Cited by 59 publications

References 97 publications

Recent Progress in Polysaccharide Aerogels: Their Synthesis, Application, and Future Outlook

Recent Progress in Polysaccharide Aerogels: Their Synthesis, Application, and Future Outlook

Chitosan modified metal–organic frameworks as a promising carrier for oral drug delivery

A Reevaluation of Chitosan-Decorated Nanoparticles to Cross the Blood-Brain Barrier

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