2010
DOI: 10.1016/j.jdent.2010.06.004
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Chitosan effect on dental enamel de-remineralization: An in vitro evaluation

Abstract: Chitosan interferes with the process of demineralization of the tooth enamel inhibiting the release of phosphorus in this laboratory study. Demineralization is influenced by the concentration and exposure time of the biopolymer to the enamel. Microhardness measurements may be used as an indication of mineral loss from tooth enamel. Additionally, OCT images support the idea that chitosan may act as a barrier against acid penetration, contributing to its demineralization inhibition.

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Cited by 150 publications
(101 citation statements)
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“…Chitosan is a natural polysaccharide derived from the deacetylation of chitin, found in the shells and exoskeleton of crustaceans [Illum, 1998]. In the pharmaceutical industry, it has been used as an excipient [Illum, 1998], but in vitro [Arnaud et al, 2010] and in vivo [Uysal et al, 2011] studies have shown some potential benefits in dentistry. It has been suggested that chitosan can form a layer-by-layer build-up on dental enamel, providing better protection against erosive attacks .…”
Section: Products Containing Other Proteins or Polymersmentioning
confidence: 99%
“…Chitosan is a natural polysaccharide derived from the deacetylation of chitin, found in the shells and exoskeleton of crustaceans [Illum, 1998]. In the pharmaceutical industry, it has been used as an excipient [Illum, 1998], but in vitro [Arnaud et al, 2010] and in vivo [Uysal et al, 2011] studies have shown some potential benefits in dentistry. It has been suggested that chitosan can form a layer-by-layer build-up on dental enamel, providing better protection against erosive attacks .…”
Section: Products Containing Other Proteins or Polymersmentioning
confidence: 99%
“…Asit ortamda yapısındaki amino grupları hidrojen iyonlarını yakalamakta ve mine yüzeyi gibi yüzeylerde pozitif yüklü bir yapı oluşturmak-tadır. 69 Tek başına kullanıldığında çürük önleyici etki göstermektedir ve son yıllarda amelogeninle birlikte kullanımının da iyi bir alternatif olduğu belirtilmektedir. 71,72 Kitosan içerikli rezin bazlı örtü-cünün de antibakteriyal etkinliğe sahip olduğu belirtilmiştir.…”
Section: Ki̇tosanunclassified
“…61,62 Tamir dentini oluşumunu sağladığı ve demineralizasyonu inhibe ettiği bulunmuştur. 63,64 Kitozanın kullanıldığı başka bir ilaç taşıyıcı sistem hidrojellerdir. Hidrojeller hidofilik polimer ağlarıdır ve büyük miktarlarda su absorbe edip hacmi hızla artan yapılardır.…”
Section: Kitozanın Biyomedikal Ve Farmasötik Uygulamalarıunclassified