Chitosan Engineered PAMAM Dendrimers as Nanoconstructs for the Enhanced Anti-Cancer Potential and Improved In vivo Brain Pharmacokinetics of Temozolomide

Kumar, Hitesh; Gupta, Lokesh Kumar; Sahu, Hitesh; Qayum, Arem; Singh, Shashank; Nakhate, Kartik T.; AJAZUDDIN, .; Gupta, Umesh

doi:10.1007/s11095-017-2324-y

Cited by 68 publications

(33 citation statements)

References 27 publications

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“…The nanoparticle improved the cytotoxic activity of sirolimus against human cancer cell lines. In another study of polyamidoamine-chitosan (PCT) carrying temozolomide, promising pharmacokinetic profiles were reported with improved AUC (1.2-fold) and prolonged t 1/2 (1.5-fold) compared with free drug 33…”

Section: Resultsmentioning

confidence: 99%

<p>Pharmacokinetic studies of nanoparticles as a delivery system for conventional drugs and herb-derived compounds for cancer therapy: a systematic review</p>

Omar

Na‐Bangchang

2019

IJN

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The poor pharmacokinetic characteristics of most anticancer drugs have limited their clinical effectiveness. The application of nanoparticles as a novel drug delivery system has provided opportunities to tackle the current challenges facing conventional drug delivery systems such as poor pharmacokinetics, lack of specificity to tumor cells, multidrug resistance, and toxicity. This systematic review aims to examine the application of pharmacokinetic studies of nanoparticles loaded in conventional drugs and herb-derived compounds for cancer therapy. The pharmacokinetic parameters of several herbal medicines and chemotherapeutic drugs loaded into nanoparticles were reported. This included area under the curve (AUC) of plasma concentration–time profile, maximum plasma concentration (Cmax), time to maximum plasma concentration (Tmax), volume of distribution (Vd or Vss), elimination half-life (t½), and clearance (CL). The systematic review was conducted using information available in the PubMed and Science Direct databases up to February 2019. The search terms employed were: pharmacokinetics, pharmacokinetic study, nanoparticles, anticancer, traditional medicine, herbal medicine, herb-derived compounds, natural products, and chemotherapy. Overall, nanoparticle carriers not only significantly improved pharmacokinetics but also further enhanced permeability, solubility, stability, specificity, and selectivity of the carried anticancer drugs/herb-derived compounds to target tumor cells. Additionally, they also limited hepatic first-pass metabolism and P-glycoprotein (P-gp) efflux of the carried anticancer drugs/herb-derived compounds. Based on this systematic review, polymeric nanoparticles were the most commonly used nanocarrier to improve the pharmacokinetic parameters. The use of nanoparticles as a novel drug delivery system has the potential to improve both pharmacokinetics and cytotoxicity activity of the loaded drugs/herb-derived compounds for cancer therapy.

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Section: Resultsmentioning

confidence: 99%

<p>Pharmacokinetic studies of nanoparticles as a delivery system for conventional drugs and herb-derived compounds for cancer therapy: a systematic review</p>

Omar

Na‐Bangchang

2019

IJN

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“…Undoubtedly it can be said that transport systems for cancer drugs based on dendrimers are the most studied and published [113][114][115][116][117][118]. This high interest is due to its versatility to mold them to the need of the system under study.…”

Section: Dendrimer As Drug Delivery Systems To Cancer Treatmentsmentioning

confidence: 99%

Dendrimers: Amazing Platforms for Bioactive Molecule Delivery Systems

Sandoval-Yáñez

Rodríguez

2020

Materials

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Today, dendrimers are the main nanoparticle applied to drug delivery systems. The physicochemical characteristics of dendrimers and their versatility structural modification make them attractive to applied as a platform to bioactive molecules transport. Nanoformulations based on dendrimers enhance low solubility drugs, arrival to the target tissue, drugs bioavailability, and controlled release. This review describes the latter approaches on the transport of bioactive molecules based on dendrimers. The review focus is on the last therapeutic strategies addressed by dendrimers conjugated with bioactive molecules. A brief review of the latest studies in therapies against cancer and cardiovascular diseases, as well as future projections in the area, are addressed.

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“…Chitosan-coated PAMAM conjugated to TMZ improved GBM tumor targeting in U-251 and T-98G cell lines at lower TMZ concentrations. In vivo pharmacokinetics exhibited sustained release with a half-life of 22.74 h in chitosan-coated dendrimer compared to free drug (TMZ alone) at 15.35 h. Reported work revealed that chitosan-anchored nanoparticles are sufficient at delivering chemotherapy across the BBB and enhanced tumor cell cytotoxicity ex vivo ( 67 ).…”

Section: Chitosan-based Delivery-systems To Brain Cancermentioning

confidence: 99%