Chitosan films and hydrogels of chlorhexidine gluconate for oral mucosal delivery

Şenel, Sevda; Ikinci, Gulcan; Kaş, S; Yousefi-Rad, A; Sargon, Mustafa F.; Hıncal, A. Atilla

doi:10.1016/s0378-5173(99)00334-8

Cited by 250 publications

(148 citation statements)

References 14 publications

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“…The film-forming property of chitosan finds many applications including food packaging, wound dressings, sutures, artificial skin, tissue engineering and drug delivery systems, especially in topical formulations. Adequate mechanical strength and flexibility are generally required for these formulations (22,23). In the past, chemical cross-linking was mostly used to prepare chitosan-based films.…”

Section: Discussionmentioning

confidence: 99%

Preparation, Characterization and Evaluation of Antifungal Efficacy of Chitosan/Soy Phosphatidylcholine Topical Films Containing Griseofulvin

Bavarsad

Kouchak

Varmaziar

et al. 2015

Jundishapur J Nat Pharm Prod

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Background:Griseofulvin is an antifungal drug and is available as oral dosage forms. Development of topical treatment could be advantageous for superficial fungal infections of skin. The film forming property of chitosan has made it interesting for transdermal/ dermal drug delivery, but showed lack of stability. Soy phosphatidylcholine (PC), besides playing penetration enhancer and solubilizer roles, could enhance the stability and mechanical properties of the film. Films prepared from a mixture of chitosan and PC can achieve the benefits of both materials. Objectives: The aim of this study was to prepare and characterize films formed from blends of chitosan and soy PC for topical delivery of griseofulvin. Materials and Methods: Topical films composed of chitosan and soy PC were prepared by means of casting and solvent evaporation technique. The properties of the films were characterized regarding mechanical properties, swelling, ability to transmit vapor, drug release, thermal behavior and antifungal efficacy against Microsporum gypseum and Epidermophyton floccosum. Results: Presence of soy PC improved mechanical properties, lowered swelling ratio and increased stability of the films. Solubilizing activity of phospholipid resulted in higher flux of drug release from formulation containing higher amount of soy PC. Antifungal efficacy of formulations was confirmed against two species of dermatophytes in vitro. Conclusions: This topical composite film had the potential for griseofulvin delivery to superficial fungal infections.

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Section: Discussionmentioning

confidence: 99%

Preparation, Characterization and Evaluation of Antifungal Efficacy of Chitosan/Soy Phosphatidylcholine Topical Films Containing Griseofulvin

Bavarsad

Kouchak

Varmaziar

et al. 2015

Jundishapur J Nat Pharm Prod

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“…Buccal delivery also enables administerings drugs to patients who cannot be dosed orally via this route (Shojaei, 1998). Many mucoadhesive buccal films have been formulated to release drugs locally in order to treat for fungal infections in the oral cavity, such as oral candidiasis (Donnelly et al, 2007;Khanna et al, 1997;Rapka et al, 2003;Senel et al, 2000). Due to the versatility of the manufacturing processes, the release can be oriented either towards the buccal mucosa or towards the oral cavity (Morales, McConville, 2011).…”

Section: Introductionmentioning

confidence: 99%

Formulation and evaluation of mucoadhesive buccal patch of acyclovir utilizing inclusion phenomenon

Saxena

Tewari

Saraf

2011

Braz. J. Pharm. Sci.

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Mucoadhesive buccal patch releasing drug in the oral cavity at a predetermined rate may present distinct advantages over traditional dosage forms, such as tablets, gels and solutions. A buccal patch for systemic administration of acyclovir in the oral cavity was developed using polymers hydroxy propyl methyl cellulose (K4M), hydroxy propyl methyl cellulose (K15M), sodium carboxy methyl cellulose and poly vinyl pyrolidone (K30), plasticizer poly ethylene glycol (400) and a backing membrane of Eudragit (RL100). The films were evaluated in terms of swelling, residence time, mucoadhesion, release, and organoleptic properties. The optimized films showed lower release as compared to controlled drug delivery systems. Hence, an inclusion complex of acyclovir was prepared with hydrophilic polymer hydroxylpropyl beta-cyclodextrin in the molar ratio of 1:1. The inclusion complex was characterized by optical microscopy, FAB mass spectroscopy, and FTIR spectroscopy. Patches formulated with the acyclovir inclusion complex were evaluated along the same lines as those containing acyclovir alone. The in vitro release data revealed a substantial increase from 64.35% to 88.15% in the case of PS I and PS II batches, respectively, confirming the successful use of inclusion complexes for the formulation of buccal patch of acyclovir.

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“…In other words, the higher the shearing rates of the gel, the faster the release of LC. Senel et al [17] also reported an increase in chlorhexidine gluconate release rate by increasing the chitosan concentration.…”

Section: Resultsmentioning

confidence: 93%

Development of bioadhesive chitosan gels for topical delivery of lidocaine

2006

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Lidocaine (LC) is a local anesthetic agent. The aim of this study is prolonging the anesthetic effect of this drug for transdermal delivery. Gels of LC hydrochloride were prepared with three different molecular weights (MW) and concentrations of chitosan. lecithin was used as permeation enhancer. Viscosity, bioadhesion, drug release from synthetic membranes, drug permeation through the biological barrier (rat skin) and antinocicetive effect of gels were studied. Increasing the concentration of chitosan caused to decrease the bioadhesion. Drug release studies in gels showed that increasing the concentration and MW of chitosan caused an increase in both the rate and extent and also in flux of drug probably because of the increase in repulsive forces between LC and chitosan cations. The flux of drug through the rat skin was higher for 3% high MW chitosan gel (H3) compared to the standard gel. LC was effective topically in hind paw formalin assay. It was most active immediately after its administration. The analgesic activity of LC in H3 gel could cover the duration of the formalin nociception. The maximal response of LC in comparable doses of H3 and standard gel was about 52% and 36% analgesia in the second phase, respectively compared to the control group.The higher response of the H3 gel may be attributed to the bioadhesive effect of chitosan base and the higher concentrations of LC compared to the standard gel.

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Chitosan films and hydrogels of chlorhexidine gluconate for oral mucosal delivery

Cited by 250 publications

References 14 publications

Preparation, Characterization and Evaluation of Antifungal Efficacy of Chitosan/Soy Phosphatidylcholine Topical Films Containing Griseofulvin

Preparation, Characterization and Evaluation of Antifungal Efficacy of Chitosan/Soy Phosphatidylcholine Topical Films Containing Griseofulvin

Formulation and evaluation of mucoadhesive buccal patch of acyclovir utilizing inclusion phenomenon

Development of bioadhesive chitosan gels for topical delivery of lidocaine

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