Chitosan–glycolic acid: a possible matrix for progesterone delivery into skin

Abstract

Chitosan-glycolic acid can be recommended as a suitable polymer for hydrogels and an adhesive matrix for a transdermal application of progesterone exhibiting excellent skin adhesiveness and permeation properties.

Chitosan-tripolyphosphate nanoparticles as a possible skin drug delivery system for aciclovir with enhanced stability

“…Chitosan (<500 kDa) in powdered form was a gift from Syntapharm (Mülheim, Germany). The degree of deacetylation was determined by NMR as 95% 11 . TPP and methanol were from Sigma‐Aldrich Chemie GmbH (Steinheim, Germany).…”

Optimization and Characterization of Chitosan Films for Transdermal Delivery of Ondansetron

“…Chitosan is able to enhance the paracellular permeability of mucosal membranes by opening the tight junctions and thereby improving the penetration of drug compounds [ 3 ]. There are also studies in which chitosan is used as a biopolymer controlling the release rate of the drug in transdermal drug delivery systems and the bioadhesive property of chitosan has great impact regarding both dermal and transdermal applications [ 8 , 11 , 12 , 13 , 14 ]. It has been proven that in stratum corneum the tight junctions between cells has negative charges similar to those found in epithelial cells.…”

Chitosan-tripolyphosphate nanoparticles as a possible skin drug delivery system for aciclovir with enhanced stability

“…The degree of deacetylation was determined by NMR as 95%. [11] TPP and methanol were from Sigma-Aldrich Chemie GmbH (Steinheim, Germany). Aciclovir was purchased from Fagron GmbH (Barsbüttel, Germany).…”