Chitosan Hydrogels and Bionanocomposites Formed through the Mineralization and Regulated Charging

Postnova, I. V.; Силантьев, В. Е.; Sarin, Sergei; Shchipunov, Yu. A.

doi:10.1002/tcr.201800049

Cited by 15 publications

(13 citation statements)

References 113 publications

(191 reference statements)

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“…Preparation of homogeneous hydrogels by direct mixing of the solutions of oppositely-charged DNA and CS is not practically possible because of phase separation of poorly defined complexes. 17,31,37,40 (Supporting Information, Figure S1).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…In addition, potential applications of such systems are limited by inadequate mechanical properties of DNA hydrogels, strong dependence of their swelling on solution conditions, and vulnerability to enzymes. Some of aforementioned disadvantages can be significantly minimized by adapting a new approach suggested recently, − to prepare a novel type of DNA-containing hydrogels based solely on physical (electrostatic) interactions between oppositely charged groups of chitosan and DNA. Chitosan, which is the only abundant cationic biomass-derived polysaccharide, covers a broad scope of applications including biomedicine and biomedical engineering, − pharmaceutics, , cosmetics, food, , agriculture, environmental remediation, , etc.…”

Section: Introductionmentioning

confidence: 99%

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DNA-Chitosan Hydrogels: Formation, Properties, and Functionalization with Catalytic Nanoparticles

Morikawa

Masubuchi

Shchipunov

et al. 2021

ACS Appl. Bio Mater.

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DNA-chitosan (DNA-CS) hydrogels were prepared on the basis of interpolyelectrolyte complexes (IPEC) in a co-assembled regime by in situ charging of the polysaccharide in a DNA solution. In contrast to poorly controlled coacervates formed upon mixing of DNA and CS solutions, stable DNA-CS IPEC hydrogels are formed at near-stoichiometric ratios of DNA and chitosan ionogenic groups. Structure, stability, and ion absorption properties of such hydrogels depended strongly on the ratio between cationic (CS) and anionic (DNA) counterparts in hydrogels. Abundant amino- and nitrogen-containing aromatic groups of co-assembled DNA and CS make their hydrogel an efficient, multitarget absorbent toward metal ions. Such strong affinity of both DNA and CS to Au3+ cation was used to entrap Au3+ ions into the DNA-CS hydrogels. Subsequent reduction of Au3+ ion inside hydrogels resulted in the formation of ∼2–3 nm size Au nanoparticles on DNA-CS scaffolds. Metallized hydrogels demonstrated catalytic activity in reduction of various nitroaromatics that depended on the ratio between CS and DNA in the hydrogel.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

DNA-Chitosan Hydrogels: Formation, Properties, and Functionalization with Catalytic Nanoparticles

Morikawa

Masubuchi

Shchipunov

et al. 2021

ACS Appl. Bio Mater.

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“…Among the industrially relevant natural polysaccharides, chitosan is the only high molecular weight cationic biopolyelectrolyte; the other naturally occurring polysaccharides for industrial uses are either neutral or anionic [ 28 , 29 ].…”

Section: Naturally Occurring Polyelectrolytesmentioning

confidence: 99%

Naturally Occurring Polyelectrolytes and Their Use for the Development of Complex-Based Mucoadhesive Drug Delivery Systems: An Overview

et al. 2021

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Biopolymers have several advantages for the development of drug delivery systems, since they are biocompatible, biodegradable and easy to obtain from renewable resources. However, their most notable advantage may be their ability to adhere to biological tissues. Many of these biopolymers have ionized forms, known as polyelectrolytes. When combined, polyelectrolytes with opposite charges spontaneously form polyelectrolyte complexes or multilayers, which have great functional versatility. Although only one natural polycation—chitosan has been widely explored until now, it has been combined with many natural polyanions such as pectin, alginate and xanthan gum, among others. These polyelectrolyte complexes have been used to develop multiple mucoadhesive dosage forms such as hydrogels, tablets, microparticles, and films, which have demonstrated extraordinary potential to administer drugs by the ocular, nasal, buccal, oral, and vaginal routes, improving both local and systemic treatments. The advantages observed for these formulations include the increased bioavailability or residence time of the formulation in the administration zone, and the avoidance of invasive administration routes, leading to greater therapeutic compliance.

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“…Postnova et al studied approaches in which monolithic hydrogels were prepared through mineralization of polysaccharide by a method of green sol-gel chemistry, compared with a method through the formation of polyelectrolyte complex [ 153 ]. It was found that both approaches were available for the preparation of films with nanoparticles and chitosan bionanocomposites.…”

Section: Organic Biopolymer-based Nanomaterials Applied In Food Pamentioning

confidence: 99%

Recent Developments in Food Packaging Based on Nanomaterials

et al. 2018

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The increasing demand for high food quality and safety, and concerns of environment sustainable development have been encouraging researchers in the food industry to exploit the robust and green biodegradable nanocomposites, which provide new opportunities and challenges for the development of nanomaterials in the food industry. This review paper aims at summarizing the recent three years of research findings on the new development of nanomaterials for food packaging. Two categories of nanomaterials (i.e., inorganic and organic) are included. The synthetic methods, physical and chemical properties, biological activity, and applications in food systems and safety assessments of each nanomaterial are presented. This review also highlights the possible mechanisms of antimicrobial activity against bacteria of certain active nanomaterials and their health concerns. It concludes with an outlook of the nanomaterials functionalized in food packaging.

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Chitosan Hydrogels and Bionanocomposites Formed through the Mineralization and Regulated Charging

Cited by 15 publications

References 113 publications

DNA-Chitosan Hydrogels: Formation, Properties, and Functionalization with Catalytic Nanoparticles

DNA-Chitosan Hydrogels: Formation, Properties, and Functionalization with Catalytic Nanoparticles

Naturally Occurring Polyelectrolytes and Their Use for the Development of Complex-Based Mucoadhesive Drug Delivery Systems: An Overview

Recent Developments in Food Packaging Based on Nanomaterials

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