Chitosan hydrogels cross-linked with tris(2-(2-formylphenoxy)ethyl)amine: Swelling and drug delivery

Karimi, Ali Reza; Rostaminejad, Bahareh; Rahimi, Leila; Khodadadi, Azam; Khanmohammadi, Hamid; Shahriari, A Hasanpour

doi:10.1016/j.ijbiomac.2018.07.037

Cited by 41 publications

(10 citation statements)

References 28 publications

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“…Swelling occurs due to an increase in the volume of the polymer as a result of solvent uptake. This mechanism is often considered in biopolymer coatings [80].…”

Section: Corrosion Studiesmentioning

confidence: 99%

Effects of Surface Pretreatment of Titanium Substrates on Properties of Electrophoretically Deposited Biopolymer Chitosan/Eudragit E 100 Coatings

et al. 2021

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The preparation of the metal surface before coating application is fundamental in determining the properties of the coatings, particularly the roughness, adhesion, and corrosion resistance. In this work, chitosan/Eudragit E 100 (chit/EE100) were fabricated by electrophoretic deposition (EPD) and both their microstructure and properties were investigated. The present research is aimed at characterizing the effects of the surface pretreatment of titanium substrate, applied deposition voltage, and time on physical, mechanical, and electrochemical properties of coatings. The coating’s microstructure, topography, thickness, wettability, adhesion, and corrosion behavior were examined. The applied process parameters influenced the morphology of the coatings, which affected their properties. Coatings with the best properties, i.e., uniformity, proper thickness and roughness, hydrophilicity, highest adhesion to the substrate, and corrosion resistance, were obtained after deposition of chit/EE100 coating on nanotubular oxide layers produced by previous electrochemical oxidation.

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“…Swelling occurs due to an increase in the volume of the polymer as a result of solvent uptake. This mechanism is often considered in biopolymer coatings [80].…”

Section: Corrosion Studiesmentioning

confidence: 99%

Effects of Surface Pretreatment of Titanium Substrates on Properties of Electrophoretically Deposited Biopolymer Chitosan/Eudragit E 100 Coatings

et al. 2021

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“…This is because the increase in temperature increases the rate of the diffusion of solution to the hydrogels and adsorption. 25 In addition, the swelling time in PBS at 37 C and in PBS at room temperature of the networks was different; PEG network, PC-0.05% and PC-0.1% reached maximum swelling in approximately 24 h. However, PC-1%, PC-2% and PC-4% had the maximum swelling in PBS at both temperatures in 2 h. This behavior can be attributed to the size and number of pores that is determined by the crosslinking between PEG and chitosan. 21 In both solutions, PC-4% exhibited the lowest swelling capability (349.58 AE 47.58% at 37 C; 262.4 AE 52.54% at room temperature).…”

Section: Discussionmentioning

confidence: 99%

Synthesis and characterization of a polymeric network made of polyethylene glycol and chitosan as a treatment with antibacterial properties for skin wounds

et al. 2020

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Polyethylene glycol has been widely investigated for wound healing and dressing applications. Despite its advantages (i.e. great biocompatibility), polyethylene glycol lacks antibacterial activity. For this reason, semi-interpenetrated polymeric networks were prepared by combining a chemically cross-linked polyethylene glycol network with chitosan. The aim of this work was to identify the best amount of chitosan able to improve the antibacterial properties against Staphylococcus aureus. Briefly, the networks were synthesized by a sequential method, adding chitosan in different proportion to the polyethylene glycol. The antibacterial activity was tested following the MGA 0100 of the Pharmacopeia of the United States of Mexico. Fourier-transform infrared with attenuated total reflection spectroscopy, scanning electron microscopy and swelling behavior PBS at 37° C and room temperature were also performed to characterize the polymeric networks. The results showed that PC-2% was able to inhibit the bacterial growth of Staphylococcus aureus even more than Fosfomycin antibiotic. The networks showed cylindrical pores of different sizes (50–100 µm). The maximum swelling of all the networks was achieved in PBS at 37°C (>315%). Free hemoglobin and hemolysis assays were also evaluated to know the compatibility with erythrocytes. Human dermal fibroblasts were used to evaluate direct cytotoxicity. Therefore, the produced gels exerted interesting antibacterial activity and showed good biocompatibility properties.

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“…A chitosan-based hydrogel using tris(2-(2-formylphenoxy)ethyl) amine as a cross-linking gelator was recently developed by Karimi and others [ 75 ]. Hydrogel formation was a result of the Schiff base formation between chitosan amine groups and aldehyde groups of the crosslinker.…”

Section: Stimuli-responsive Chitosanmentioning

confidence: 99%

Recent Applications of Dual-Stimuli Responsive Chitosan Hydrogel Nanocomposites as Drug Delivery Tools

2021

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Polysaccharides are a versatile class of macromolecules that are involved in many biological interactions critical to life. They can be further modified for added functionality. Once derivatized, these polymers can exhibit new chemical properties that can be further optimized for applications in drug delivery, wound healing, sensor development and others. Chitosan, derived from the N-deacetylation of chitin, is one example of a polysaccharide that has been functionalized and used as a major component of polysaccharide biomaterials. In this brief review, we focus on one aspect of chitosan’s utility, namely we discuss recent advances in dual-responsive chitosan hydrogel nanomaterials.

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Chitosan hydrogels cross-linked with tris(2-(2-formylphenoxy)ethyl)amine: Swelling and drug delivery

Cited by 41 publications

References 28 publications

Effects of Surface Pretreatment of Titanium Substrates on Properties of Electrophoretically Deposited Biopolymer Chitosan/Eudragit E 100 Coatings

Effects of Surface Pretreatment of Titanium Substrates on Properties of Electrophoretically Deposited Biopolymer Chitosan/Eudragit E 100 Coatings

Synthesis and characterization of a polymeric network made of polyethylene glycol and chitosan as a treatment with antibacterial properties for skin wounds

Recent Applications of Dual-Stimuli Responsive Chitosan Hydrogel Nanocomposites as Drug Delivery Tools

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